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- W2891525728 endingPage "2885" @default.
- W2891525728 startingPage "2885" @default.
- W2891525728 abstract "Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cells. A typical feature of CCA is its highly desmoplastic microenvironment containing fibrogenic connective tissue and an abundance of immune cells (T lymphocytes, Natural Killer (NK) cells, and macrophages) infiltrating tumor epithelium. This strong desmoplasia is orchestrated by various soluble factors and signals, suggesting a critical role in shaping a tumor growth-permissive microenvironment that is responsible for CCA poor clinical outcome. Indeed stroma not only provides an abundance of factors that facilitate CCA initiation, growth and progression, but also a prejudicial impact on therapeutic outcome. This review will give an overview of tumor-stroma signaling in a microenvironment critically regulating CCA development and progression. Identification of CCA secreted factors by both the fibroblast component and immune cell subsets might provide ample opportunities for pharmacological targeting of this type of cancer." @default.
- W2891525728 created "2018-09-27" @default.
- W2891525728 creator A5041194397 @default.
- W2891525728 creator A5063987323 @default.
- W2891525728 creator A5071125084 @default.
- W2891525728 creator A5076657757 @default.
- W2891525728 date "2018-09-22" @default.
- W2891525728 modified "2023-10-06" @default.
- W2891525728 title "The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium" @default.
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