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- W2891532655 abstract "Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain, hinge region, and ligand-binding domain. AR plays pivotal roles in prostate cancer, especially castration-resistant prostate cancer (CRPC). Androgen deprivation therapy can suppress hormone-naïve prostate cancer, but prostate cancer changes AR and adapts to survive under castration levels of androgen. These mechanisms include AR point mutations, AR overexpression, changes of androgen biosynthesis, constitutively active AR splice variants without ligand binding, and changes of androgen cofactors. Studies of AR in CRPC revealed that AR was still active in CRPC, and it remains as a potential target to treat CRPC. Enzalutamide is a second-generation antiandrogen effective in patients with CRPC before and after taxane-based chemotherapy. However, CRPC is still incurable and can develop drug resistance. Understanding the mechanisms of this resistance can enable new-generation therapies for CRPC. Several promising new AR-targeted therapies have been developed. Apalutamide is a new Food and Drug Administration-approved androgen agonist binding to the ligand-binding domain, and clinical trials of other new AR-targeted agents binding to the ligand-binding domain or N-terminal domain are underway. This review focuses on the functions of AR in prostate cancer and the development of CRPC and promising new agents against CRPC." @default.
- W2891532655 created "2018-09-27" @default.
- W2891532655 creator A5072709086 @default.
- W2891532655 creator A5088384086 @default.
- W2891532655 date "2019-01-01" @default.
- W2891532655 modified "2023-10-18" @default.
- W2891532655 title "Role of Androgen Receptor in Prostate Cancer: A Review" @default.
- W2891532655 cites W1578291413 @default.
- W2891532655 cites W1593653036 @default.
- W2891532655 cites W1740737174 @default.
- W2891532655 cites W1844925317 @default.
- W2891532655 cites W1963137324 @default.
- W2891532655 cites W1965283193 @default.
- W2891532655 cites W1984248209 @default.
- W2891532655 cites W1988058596 @default.
- W2891532655 cites W2013933651 @default.
- W2891532655 cites W2022635468 @default.
- W2891532655 cites W2023591758 @default.
- W2891532655 cites W2032432671 @default.
- W2891532655 cites W2036274810 @default.
- W2891532655 cites W2051025382 @default.
- W2891532655 cites W2055655957 @default.
- W2891532655 cites W2061271065 @default.
- W2891532655 cites W2068677163 @default.
- W2891532655 cites W2068827259 @default.
- W2891532655 cites W2069153889 @default.
- W2891532655 cites W2079081853 @default.
- W2891532655 cites W2084637523 @default.
- W2891532655 cites W2089118589 @default.
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- W2891532655 doi "https://doi.org/10.5534/wjmh.180040" @default.
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