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- W2891538051 abstract "The efficacy of the adaptive humoral immune response likely requires diverse, yet focused regional B cell antibody production throughout the body. Here we address, in the first study of its kind, the B cell repertoire in the bronchial mucosa, an important barrier to antigens inhaled from the atmosphere. To accomplish this we have applied high-throughput Adaptive Immune Receptor Repertoire Sequencing (AIRR-Seq) to 10 bronchial biopsies from altogether four different sites in the right lungs from an asthmatic patient and a healthy control subject. While the majority of identified B cell clones were restricted to a single site, many were disseminated in multiple sites. Members of a clone were shared more between adjacent biopsies than between distal biopsies, suggesting local mucosal migration and/or a homing mechanism for B cells through the blood or lymph. A smaller fraction of clones spanned the bronchial mucosa and peripheral blood, suggesting ongoing trafficking between these compartments. The bronchial mucosal B cell repertoire in the asthmatic patient was geographically more variable but less diverse compared to that of the control subject, suggesting an ongoing, antigen-driven humoral immune response. We observed a subset of highly mutated and antigen-selected IgD-only cells in the bronchial mucosa. These cells were found at a high proportion in the asthmatic individual but also, albeit in lower proportion, in the healthy control subject." @default.
- W2891538051 created "2018-09-27" @default.
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- W2891538051 date "2018-09-07" @default.
- W2891538051 modified "2023-10-11" @default.
- W2891538051 title "Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa" @default.
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- W2891538051 doi "https://doi.org/10.3389/fimmu.2018.01976" @default.
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