FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891539116> ?p ?o ?g. }

• W2891539116 endingPage "50" @default.
• W2891539116 startingPage "44" @default.
• W2891539116 abstract "Stress-induced prothrombotic changes are mediated by the sympathetic nervous system and critically involved in mental triggering of acute coronary syndromes, but the underlying psychobiology is not fully understood. We tested the hypothesis that a norepinephrine (NE) infusion to mimic effects of stress-induced NE release on blood coagulation elicits prothrombotic changes and examined to what extent these would be mediated by an alpha-adrenergic mechanism.In a single-blind placebo-controlled within-subjects design, 24 middle-aged, non-smoking, non-obese and normotensive men participated in three experimental trials with an interval between one and two weeks. Each trial applied two sequential infusions of 1 and 15 min duration with varying substances [i.e., saline as placebo, the non-specific α-blocker phentolamine (2.5 mg/min), and NE (5 μg/min)]: trial 1=saline + saline; trial 2=saline + NE, and trial 3=phentolamine + NE. Plasma levels of clotting factor VIII activity (FVIII:C), fibrinogen, and D-dimer were assessed from blood samples collected immediately before and 1 min and 20 min after infusion procedures. Compared to saline + saline, saline + NE induced increases over time in FVIII:C, fibrinogen, and D-dimer levels. With phentolamine + NE, fibrinogen levels remained increased compared to saline + saline, but changes in FVIII:C and D-dimer levels were no more different. Coagulation changes did not differ between saline + NE and phentolamine + NE.NE infusion activates blood coagulation. The resulting prothrombotic state could be one psychobiological mechanism underlying mental triggering of acute coronary syndromes. Blockade of α-adrenergic receptors partly attenuated NE effects on coagulation and could be implied to have preventive potential in susceptible individuals." @default.
• W2891539116 created "2018-09-27" @default.
• W2891539116 creator A5021845205 @default.
• W2891539116 creator A5032741497 @default.
• W2891539116 creator A5049414539 @default.
• W2891539116 creator A5054097476 @default.
• W2891539116 creator A5057279591 @default.
• W2891539116 creator A5078217300 @default.
• W2891539116 creator A5090741853 @default.
• W2891539116 date "2019-07-01" @default.
• W2891539116 modified "2023-10-18" @default.
• W2891539116 title "Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms" @default.
• W2891539116 cites W1521026192 @default.
• W2891539116 cites W1819753035 @default.
• W2891539116 cites W1974785222 @default.
• W2891539116 cites W1984486655 @default.
• W2891539116 cites W1985809814 @default.
• W2891539116 cites W1991093380 @default.
• W2891539116 cites W2003627971 @default.
• W2891539116 cites W2012491402 @default.
• W2891539116 cites W2016709601 @default.
• W2891539116 cites W2021822189 @default.
• W2891539116 cites W2023177811 @default.
• W2891539116 cites W2030208515 @default.
• W2891539116 cites W2035126508 @default.
• W2891539116 cites W2039215789 @default.
• W2891539116 cites W2039912040 @default.
• W2891539116 cites W2043208298 @default.
• W2891539116 cites W2043789620 @default.
• W2891539116 cites W2046247859 @default.
• W2891539116 cites W2046710512 @default.
• W2891539116 cites W2048692863 @default.
• W2891539116 cites W2056259357 @default.
• W2891539116 cites W2057711799 @default.
• W2891539116 cites W2064389384 @default.
• W2891539116 cites W2066328889 @default.
• W2891539116 cites W2068926236 @default.
• W2891539116 cites W2071710501 @default.
• W2891539116 cites W2072389786 @default.
• W2891539116 cites W2072479238 @default.
• W2891539116 cites W2072691782 @default.
• W2891539116 cites W2075998344 @default.
• W2891539116 cites W2079785181 @default.
• W2891539116 cites W2090655603 @default.
• W2891539116 cites W2092134375 @default.
• W2891539116 cites W2096674194 @default.
• W2891539116 cites W2109913483 @default.
• W2891539116 cites W2116876100 @default.
• W2891539116 cites W2118445851 @default.
• W2891539116 cites W2125565293 @default.
• W2891539116 cites W2127608484 @default.
• W2891539116 cites W2130480738 @default.
• W2891539116 cites W2133427224 @default.
• W2891539116 cites W2144015687 @default.
• W2891539116 cites W2154842710 @default.
• W2891539116 cites W2156234092 @default.
• W2891539116 cites W2329213056 @default.
• W2891539116 cites W2402564818 @default.
• W2891539116 cites W2462383593 @default.
• W2891539116 cites W2499073966 @default.
• W2891539116 cites W2756023329 @default.
• W2891539116 cites W2810669868 @default.
• W2891539116 cites W9793971 @default.
• W2891539116 doi "https://doi.org/10.1016/j.psyneuen.2018.09.018" @default.
• W2891539116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318393" @default.
• W2891539116 hasPublicationYear "2019" @default.
• W2891539116 type Work @default.
• W2891539116 sameAs 2891539116 @default.
• W2891539116 citedByCount "8" @default.
• W2891539116 countsByYear W28915391162020 @default.
• W2891539116 countsByYear W28915391162021 @default.
• W2891539116 countsByYear W28915391162022 @default.
• W2891539116 countsByYear W28915391162023 @default.
• W2891539116 crossrefType "journal-article" @default.
• W2891539116 hasAuthorship W2891539116A5021845205 @default.
• W2891539116 hasAuthorship W2891539116A5032741497 @default.
• W2891539116 hasAuthorship W2891539116A5049414539 @default.
• W2891539116 hasAuthorship W2891539116A5054097476 @default.
• W2891539116 hasAuthorship W2891539116A5057279591 @default.
• W2891539116 hasAuthorship W2891539116A5078217300 @default.
• W2891539116 hasAuthorship W2891539116A5090741853 @default.
• W2891539116 hasConcept C126322002 @default.
• W2891539116 hasConcept C134018914 @default.
• W2891539116 hasConcept C185592680 @default.
• W2891539116 hasConcept C2776533406 @default.
• W2891539116 hasConcept C2777397205 @default.
• W2891539116 hasConcept C2778151854 @default.
• W2891539116 hasConcept C2778514916 @default.
• W2891539116 hasConcept C2779036427 @default.
• W2891539116 hasConcept C2780253649 @default.
• W2891539116 hasConcept C42219234 @default.
• W2891539116 hasConcept C513476851 @default.
• W2891539116 hasConcept C71924100 @default.
• W2891539116 hasConcept C84393581 @default.
• W2891539116 hasConceptScore W2891539116C126322002 @default.
• W2891539116 hasConceptScore W2891539116C134018914 @default.
• W2891539116 hasConceptScore W2891539116C185592680 @default.
• W2891539116 hasConceptScore W2891539116C2776533406 @default.

• next