FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891544251> ?p ?o ?g. }

• W2891544251 endingPage "349" @default.
• W2891544251 startingPage "340" @default.
• W2891544251 abstract "The current knowledge of pathophysiological and molecular mechanisms responsible for the genesis and development of heart failure (HF) is absolutely vast. Nonetheless, the hiatus between experimental findings and therapeutic options remains too deep, while the available pharmacological treatments are mostly seasoned and display limited efficacy. The necessity to identify new, non-pharmacological strategies to target molecular alterations led investigators, already many years ago, to propose gene therapy for HF. Here, we will review some of the strategies proposed over the past years to target major pathogenic mechanisms/factors responsible for severe cardiac injury developing into HF and will provide arguments in favor of the necessity to keep alive research on this topic. After decades of preclinical research and phases of enthusiasm and disappointment, clinical trials were finally launched in recent years. The first one to reach phase II and testing gene delivery of sarcoendoplasmic reticulum calcium ATPase did not yield encouraging results; however, other trials are ongoing, more efficient viral vectors are being developed, and promising new potential targets have been identified. For instance, recent research is focused on gene repair, in vivo, to treat heritable forms of HF, while strong experimental evidence indicates that specific microRNAs can be delivered to post-ischemic hearts to induce regeneration, a result that was previously thought possible only by using stem cell therapy. Gene therapy for HF is aging, but exciting perspectives are still very open." @default.
• W2891544251 created "2018-09-27" @default.
• W2891544251 creator A5009822156 @default.
• W2891544251 creator A5064626414 @default.
• W2891544251 date "2018-09-20" @default.
• W2891544251 modified "2023-10-05" @default.
• W2891544251 title "Gene Therapy for Heart Failure: New Perspectives" @default.
• W2891544251 cites W101757858 @default.
• W2891544251 cites W1533447420 @default.
• W2891544251 cites W1576493459 @default.
• W2891544251 cites W1764072566 @default.
• W2891544251 cites W1781484722 @default.
• W2891544251 cites W1887024293 @default.
• W2891544251 cites W1895538147 @default.
• W2891544251 cites W1926939363 @default.
• W2891544251 cites W1961082629 @default.
• W2891544251 cites W1963935356 @default.
• W2891544251 cites W1968543820 @default.
• W2891544251 cites W1969210272 @default.
• W2891544251 cites W1970104310 @default.
• W2891544251 cites W1970576676 @default.
• W2891544251 cites W1974016845 @default.
• W2891544251 cites W1982942713 @default.
• W2891544251 cites W1983922247 @default.
• W2891544251 cites W1987229981 @default.
• W2891544251 cites W1987648149 @default.
• W2891544251 cites W1990704706 @default.
• W2891544251 cites W1997975349 @default.
• W2891544251 cites W2006086569 @default.
• W2891544251 cites W2006653825 @default.
• W2891544251 cites W2008882422 @default.
• W2891544251 cites W2015870495 @default.
• W2891544251 cites W2020020716 @default.
• W2891544251 cites W2024918253 @default.
• W2891544251 cites W2027440191 @default.
• W2891544251 cites W2027527792 @default.
• W2891544251 cites W2032902046 @default.
• W2891544251 cites W2033179276 @default.
• W2891544251 cites W2045233735 @default.
• W2891544251 cites W2046549076 @default.
• W2891544251 cites W2048303185 @default.
• W2891544251 cites W2049094551 @default.
• W2891544251 cites W2050712486 @default.
• W2891544251 cites W2053849856 @default.
• W2891544251 cites W2054604628 @default.
• W2891544251 cites W2056110140 @default.
• W2891544251 cites W2061013034 @default.
• W2891544251 cites W2061471552 @default.
• W2891544251 cites W2068327935 @default.
• W2891544251 cites W2074128516 @default.
• W2891544251 cites W2074771766 @default.
• W2891544251 cites W2086420473 @default.
• W2891544251 cites W2088749722 @default.
• W2891544251 cites W2093054335 @default.
• W2891544251 cites W2095375270 @default.
• W2891544251 cites W2099538751 @default.
• W2891544251 cites W2099757528 @default.
• W2891544251 cites W2101166356 @default.
• W2891544251 cites W2101986300 @default.
• W2891544251 cites W2107696376 @default.
• W2891544251 cites W2108297050 @default.
• W2891544251 cites W2110345320 @default.
• W2891544251 cites W2110557028 @default.
• W2891544251 cites W2110597510 @default.
• W2891544251 cites W2112943033 @default.
• W2891544251 cites W2117412164 @default.
• W2891544251 cites W2123490348 @default.
• W2891544251 cites W2126612843 @default.
• W2891544251 cites W2129399211 @default.
• W2891544251 cites W2135927881 @default.
• W2891544251 cites W2136875374 @default.
• W2891544251 cites W2140775408 @default.
• W2891544251 cites W2142190754 @default.
• W2891544251 cites W2142897841 @default.
• W2891544251 cites W2145178074 @default.
• W2891544251 cites W2145565015 @default.
• W2891544251 cites W2148120054 @default.
• W2891544251 cites W2149400236 @default.
• W2891544251 cites W2157506278 @default.
• W2891544251 cites W2157581901 @default.
• W2891544251 cites W2158170306 @default.
• W2891544251 cites W2164356347 @default.
• W2891544251 cites W2167150144 @default.
• W2891544251 cites W2167659424 @default.
• W2891544251 cites W2168681708 @default.
• W2891544251 cites W2169617094 @default.
• W2891544251 cites W2169817146 @default.
• W2891544251 cites W2186484749 @default.
• W2891544251 cites W2208696160 @default.
• W2891544251 cites W2223413920 @default.
• W2891544251 cites W2268090074 @default.
• W2891544251 cites W2271175958 @default.
• W2891544251 cites W2290678689 @default.
• W2891544251 cites W2296388277 @default.
• W2891544251 cites W2327796497 @default.
• W2891544251 cites W2341478304 @default.
• W2891544251 cites W2397220502 @default.
• W2891544251 cites W2410727690 @default.

• next