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• W2891545181 abstract "Abstract Gastrointestinal problems are common in elderly and often associated with psychological distress and increased levels of corticotrophin-releasing hormone, a hormone known to cause mast cell (MC) degranulation and perturbed intestinal barrier function. We investigated if dietary fibres (non-digestible polysaccharides [NPS]) could attenuate MC-induced colonic hyperpermeability in elderly with gastrointestinal (GI) symptoms. Colonic biopsies from elderly with diarrhoea and/or constipation (n = 18) and healthy controls (n = 19) were mounted in Ussing chambers and pre-stimulated with a yeast-derived beta (β)-glucan (0.5 mg/ml) or wheat-derived arabinoxylan (0.1 mg/ml) before the addition of the MC-degranulator Compound (C) 48/80 (10 ng/ml). Permeability markers were compared pre and post exposure to C48/80 in both groups and revealed higher baseline permeability in elderly with GI symptoms. β-glucan significantly attenuated C48/80-induced hyperpermeability in elderly with GI symptoms but not in healthy controls. Arabinoxylan reduced MC-induced paracellular and transcellular hyperpermeability across the colonic mucosa of healthy controls, but did only attenuate transcellular permeability in elderly with GI symptoms. Our novel findings indicate that NPS affect the intestinal barrier differently depending on the presence of GI symptoms and could be important in the treatment of moderate constipation and/or diarrhoea in elderly." @default.
• W2891545181 created "2018-09-27" @default.
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• W2891545181 date "2018-09-07" @default.
• W2891545181 modified "2023-10-14" @default.
• W2891545181 title "Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms" @default.
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• W2891545181 doi "https://doi.org/10.1038/s41598-018-31492-5" @default.
• W2891545181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128877" @default.
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• W2891545181 hasPublicationYear "2018" @default.
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