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- W2891545928 abstract "Abstract It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genes CHP1 , SMAD2 , FZD6 and SIAH1 ." @default.
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- W2891545928 date "2018-09-21" @default.
- W2891545928 modified "2023-10-10" @default.
- W2891545928 title "The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat" @default.
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- W2891545928 doi "https://doi.org/10.1038/s41598-018-31986-2" @default.
- W2891545928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155037" @default.
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