Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891550135> ?p ?o ?g. }
- W2891550135 endingPage "655" @default.
- W2891550135 startingPage "637" @default.
- W2891550135 abstract "Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in bacteria and yeast at the plasma membrane, which activates intracellular signal transduction to control the expression of Pi transporters and other genes that control intracellular Pi levels. In multicellular organisms, Pi homeostasis must be maintained in the organism and at the cellular level, requiring an endocrine and metabolic Pi-sensing mechanism, about which little is currently known. This Review will discuss the metabolic effects of Pi, which are mediated by Pi transporters, inositol pyrophosphates and SYG1-Pho81-XPR1 (SPX)-domain proteins to maintain cellular phosphate homeostasis in the musculoskeletal system. In addition, we will discuss how Pi is sensed by the human body to regulate the production of fibroblast growth factor 23 (FGF23), parathyroid hormone and calcitriol to maintain serum levels of Pi in a narrow range. New findings on the crosstalk between iron and Pi homeostasis in the regulation of FGF23 expression will also be outlined. Mutations in components of these metabolic and endocrine phosphate sensors result in genetic disorders of phosphate homeostasis, cardiomyopathy and familial basal ganglial calcifications, highlighting the importance of this newly emerging area of research." @default.
- W2891550135 created "2018-09-27" @default.
- W2891550135 creator A5015800579 @default.
- W2891550135 creator A5062737561 @default.
- W2891550135 date "2018-09-14" @default.
- W2891550135 modified "2023-10-02" @default.
- W2891550135 title "Role of phosphate sensing in bone and mineral metabolism" @default.
- W2891550135 cites W1061587717 @default.
- W2891550135 cites W1481991655 @default.
- W2891550135 cites W1483951471 @default.
- W2891550135 cites W1498584081 @default.
- W2891550135 cites W1522931413 @default.
- W2891550135 cites W1549105976 @default.
- W2891550135 cites W1563425273 @default.
- W2891550135 cites W1576362854 @default.
- W2891550135 cites W1602110651 @default.
- W2891550135 cites W1605020879 @default.
- W2891550135 cites W1624489934 @default.
- W2891550135 cites W1786268878 @default.
- W2891550135 cites W1804847573 @default.
- W2891550135 cites W1825405603 @default.
- W2891550135 cites W1825694147 @default.
- W2891550135 cites W1842778530 @default.
- W2891550135 cites W1852662395 @default.
- W2891550135 cites W1853980819 @default.
- W2891550135 cites W1870235011 @default.
- W2891550135 cites W1930269857 @default.
- W2891550135 cites W1963306946 @default.
- W2891550135 cites W1965943515 @default.
- W2891550135 cites W1966057347 @default.
- W2891550135 cites W1967335310 @default.
- W2891550135 cites W1967502057 @default.
- W2891550135 cites W1969715936 @default.
- W2891550135 cites W1970305413 @default.
- W2891550135 cites W1970513264 @default.
- W2891550135 cites W1971023242 @default.
- W2891550135 cites W1971712671 @default.
- W2891550135 cites W1971783341 @default.
- W2891550135 cites W1973016545 @default.
- W2891550135 cites W1973649277 @default.
- W2891550135 cites W1974807791 @default.
- W2891550135 cites W1975611493 @default.
- W2891550135 cites W1975922133 @default.
- W2891550135 cites W1976776496 @default.
- W2891550135 cites W1980594318 @default.
- W2891550135 cites W1980820355 @default.
- W2891550135 cites W1980828936 @default.
- W2891550135 cites W1982064426 @default.
- W2891550135 cites W1982817150 @default.
- W2891550135 cites W1983579422 @default.
- W2891550135 cites W1985046929 @default.
- W2891550135 cites W1985464840 @default.
- W2891550135 cites W1985564086 @default.
- W2891550135 cites W1987136031 @default.
- W2891550135 cites W1987979515 @default.
- W2891550135 cites W1988119351 @default.
- W2891550135 cites W1988170766 @default.
- W2891550135 cites W1988897099 @default.
- W2891550135 cites W1989272978 @default.
- W2891550135 cites W1990665236 @default.
- W2891550135 cites W1991600999 @default.
- W2891550135 cites W1994611947 @default.
- W2891550135 cites W1995081248 @default.
- W2891550135 cites W1995873637 @default.
- W2891550135 cites W1995911293 @default.
- W2891550135 cites W1998046992 @default.
- W2891550135 cites W1998843350 @default.
- W2891550135 cites W1999892434 @default.
- W2891550135 cites W2000004275 @default.
- W2891550135 cites W2000221281 @default.
- W2891550135 cites W2001634169 @default.
- W2891550135 cites W2001652555 @default.
- W2891550135 cites W2008101181 @default.
- W2891550135 cites W2008282188 @default.
- W2891550135 cites W2008948664 @default.
- W2891550135 cites W2011291658 @default.
- W2891550135 cites W2012675371 @default.
- W2891550135 cites W2015005969 @default.
- W2891550135 cites W2016390309 @default.
- W2891550135 cites W2016391867 @default.
- W2891550135 cites W2017867552 @default.
- W2891550135 cites W2018209127 @default.
- W2891550135 cites W2018568080 @default.
- W2891550135 cites W2018624898 @default.
- W2891550135 cites W2018876830 @default.
- W2891550135 cites W2018924747 @default.
- W2891550135 cites W2019397580 @default.
- W2891550135 cites W2020162188 @default.
- W2891550135 cites W2021085051 @default.
- W2891550135 cites W2021694330 @default.
- W2891550135 cites W2021854879 @default.
- W2891550135 cites W2023446262 @default.
- W2891550135 cites W2025075383 @default.
- W2891550135 cites W2025096526 @default.
- W2891550135 cites W2026864319 @default.
- W2891550135 cites W2028480953 @default.
- W2891550135 cites W2028563396 @default.
- W2891550135 cites W2028794801 @default.