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• W2891552310 endingPage "e3151" @default.
• W2891552310 startingPage "e3151" @default.
• W2891552310 abstract "Computational cardiac mechanical models, individualized to the patient, have the potential to elucidate the fundamentals of cardiac (patho-)physiology, enable non-invasive quantification of clinically significant metrics (eg, stiffness, active contraction, work), and anticipate the potential efficacy of therapeutic cardiovascular intervention. In a clinical setting, however, the available imaging resolution is often limited, which limits cardiac models to focus on the ventricles, without including the atria, valves, and proximal arteries and veins. In such models, the absence of surrounding structures needs to be accounted for by imposing realistic kinematic boundary conditions, which, for prognostic purposes, are preferably generic and thus non-image derived. Unfortunately, the literature on cardiac models shows no consistent approach to kinematically constrain the myocardium. The impact of different approaches (eg, fully constrained base, constrained epi-ring) on the predictive capacity of cardiac mechanical models has not been thoroughly studied. For that reason, this study first gives an overview of current approaches to kinematically constrain (bi) ventricular models. Next, we developed a patient-specific in silico biventricular model that compares well with literature and in vivo recorded strains. Alternative constraints were introduced to assess the influence of commonly used mechanical boundary conditions on both the predicted global functional behavior of the in-silico heart (cavity volumes, stroke volume, ejection fraction) and local strain distributions. Meaningful differences in global functioning were found between different kinematic anchoring strategies, which brought forward the importance of selecting appropriate boundary conditions for biventricular models that, in the near future, may inform clinical intervention. However, whilst statistically significant differences were also found in local strain distributions, these differences were minor and mostly confined to the region close to the applied boundary conditions." @default.
• W2891552310 created "2018-09-27" @default.
• W2891552310 creator A5004827011 @default.
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• W2891552310 creator A5083061034 @default.
• W2891552310 date "2018-10-07" @default.
• W2891552310 modified "2023-09-29" @default.
• W2891552310 title "Kinematic boundary conditions substantially impact in silico ventricular function" @default.
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• W2891552310 cites W1530806320 @default.
• W2891552310 cites W1544180994 @default.
• W2891552310 cites W1593343011 @default.
• W2891552310 cites W1650849552 @default.
• W2891552310 cites W1854898238 @default.
• W2891552310 cites W1869323667 @default.
• W2891552310 cites W1870638042 @default.
• W2891552310 cites W1887330272 @default.
• W2891552310 cites W1892419343 @default.
• W2891552310 cites W1968687630 @default.
• W2891552310 cites W1968814354 @default.
• W2891552310 cites W1970486551 @default.
• W2891552310 cites W1973756207 @default.
• W2891552310 cites W1977098804 @default.
• W2891552310 cites W1983390714 @default.
• W2891552310 cites W1986005020 @default.
• W2891552310 cites W2000996567 @default.
• W2891552310 cites W2004132287 @default.
• W2891552310 cites W2010365263 @default.
• W2891552310 cites W2015662113 @default.
• W2891552310 cites W2021860244 @default.
• W2891552310 cites W2024001317 @default.
• W2891552310 cites W2037127309 @default.
• W2891552310 cites W2048501778 @default.
• W2891552310 cites W2052084935 @default.
• W2891552310 cites W2055237476 @default.
• W2891552310 cites W2055577088 @default.
• W2891552310 cites W2058817926 @default.
• W2891552310 cites W2059010914 @default.
• W2891552310 cites W2059473928 @default.
• W2891552310 cites W2063021867 @default.
• W2891552310 cites W2067063480 @default.
• W2891552310 cites W2070366581 @default.
• W2891552310 cites W2086441377 @default.
• W2891552310 cites W2089194947 @default.
• W2891552310 cites W2089613060 @default.
• W2891552310 cites W2090213412 @default.
• W2891552310 cites W2096554670 @default.
• W2891552310 cites W2102339840 @default.
• W2891552310 cites W2103171693 @default.
• W2891552310 cites W2107836188 @default.
• W2891552310 cites W2110256784 @default.
• W2891552310 cites W2122482159 @default.
• W2891552310 cites W2127207761 @default.
• W2891552310 cites W2129654146 @default.
• W2891552310 cites W2131414969 @default.
• W2891552310 cites W2132401137 @default.
• W2891552310 cites W2132670047 @default.
• W2891552310 cites W2134374457 @default.
• W2891552310 cites W2135965207 @default.
• W2891552310 cites W2136415481 @default.
• W2891552310 cites W2137128251 @default.
• W2891552310 cites W2146002889 @default.
• W2891552310 cites W2153784828 @default.
• W2891552310 cites W2161461686 @default.
• W2891552310 cites W2166928160 @default.
• W2891552310 cites W2174707238 @default.
• W2891552310 cites W2178593575 @default.
• W2891552310 cites W2240155340 @default.
• W2891552310 cites W2268777004 @default.
• W2891552310 cites W2293886803 @default.
• W2891552310 cites W2419555779 @default.
• W2891552310 cites W2425457085 @default.
• W2891552310 cites W2428413273 @default.
• W2891552310 cites W2509692229 @default.
• W2891552310 cites W2511668737 @default.
• W2891552310 cites W2513146229 @default.
• W2891552310 cites W2521434808 @default.
• W2891552310 cites W2525514525 @default.
• W2891552310 cites W2531404687 @default.
• W2891552310 cites W2532627760 @default.
• W2891552310 cites W2565305875 @default.
• W2891552310 cites W2588044023 @default.
• W2891552310 cites W2625704543 @default.
• W2891552310 cites W2781815743 @default.
• W2891552310 cites W2786946573 @default.
• W2891552310 cites W2790905066 @default.
• W2891552310 cites W2792201697 @default.
• W2891552310 cites W2805429448 @default.
• W2891552310 doi "https://doi.org/10.1002/cnm.3151" @default.
• W2891552310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30188608" @default.
• W2891552310 hasPublicationYear "2018" @default.
• W2891552310 type Work @default.

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