FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891555609> ?p ?o ?g. }

• W2891555609 abstract "Abstract Background Although definitive chemoradiotherapy (CRT) with salvage esophagectomy has improved overall survival (OS) for esophageal cancer, it is a more invasive approach than neoadjuvant CRT followed by surgery or surgery alone, and causes high mortality after surgery. The purpose of this study was to investigate the short and long-term outcomes of salvage esophagectomy, to determine their prognostic factors, and to create a prediction model for OS using a classification and regression tree (CART). Methods Ninety patients who had undergone CRT followed by esophagectomy for thoracic esophageal cancer at Keio University Hospital, Tokyo, Japan, between June 1994 and August 2014 were identified for this study. We divided the 90 patients into two groups—the salvage group and the neoadjuvant group—according to the dose of irradiation of CRT. Forty-four patients who underwent CRT with radiation dose less than 50 Gy, followed by planned esophagectomy, were allocated to the neoadjuvant group. Forty-six patients with salvage esophagectomy for locally recurrent or residual cancer after definitive CRT (greater than 50 Gy) were allocated to the salvage group. Results Patients from the salvage group tended to have a lower OS (median survival: Salvage, 25 months vs neoadjuvant, 50 months, P = 0.149). In the salvage group, pneumonia and age were identified as factors predictive of in-hospital mortality. OS was significantly lower in patients with postoperative pneumonia and female gender. We set the prediction model for OS in the salvage group using survival CART. The group of R1/2 resection aged ≥ 56.5 years and the group suffering from postoperative pneumonia were the groups at highest risk; the area under the curve was 0.72. Conclusion The present study demonstrates the short-term and long-term prognostic factors of salvage esophagectomy after definitive CRT for esophageal cancer. Achieving improvement in OS after salvage surgery requires increased R0 resection rates and decreased pulmonary complications. Both informed decision making in the adoption of salvage surgery and specific plans to reduce pneumonia through means such as pulmonary rehabilitation are required. Disclosure All authors have declared no conflicts of interest." @default.
• W2891555609 created "2018-09-27" @default.
• W2891555609 creator A5008461685 @default.
• W2891555609 creator A5018112691 @default.
• W2891555609 creator A5021991762 @default.
• W2891555609 creator A5023240171 @default.
• W2891555609 creator A5024659721 @default.
• W2891555609 creator A5032766781 @default.
• W2891555609 creator A5035788629 @default.
• W2891555609 creator A5081583597 @default.
• W2891555609 date "2018-09-01" @default.
• W2891555609 modified "2023-09-27" @default.
• W2891555609 title "RA10.04: POSTOPERATIVE PNEUMONIA IS ASSOCIATED WITH SHORT-TERM AND LONG-TERM MORTALITY OF DEFINITIVE CHEMORADIOTHERAPY FOLLOWED BY SALVAGE ESOPHAGECTOMY FOR ESOPHAGEAL CANCER" @default.
• W2891555609 doi "https://doi.org/10.1093/dote/doy089.ra10.04" @default.
• W2891555609 hasPublicationYear "2018" @default.
• W2891555609 type Work @default.
• W2891555609 sameAs 2891555609 @default.
• W2891555609 citedByCount "0" @default.
• W2891555609 crossrefType "journal-article" @default.
• W2891555609 hasAuthorship W2891555609A5008461685 @default.
• W2891555609 hasAuthorship W2891555609A5018112691 @default.
• W2891555609 hasAuthorship W2891555609A5021991762 @default.
• W2891555609 hasAuthorship W2891555609A5023240171 @default.
• W2891555609 hasAuthorship W2891555609A5024659721 @default.
• W2891555609 hasAuthorship W2891555609A5032766781 @default.
• W2891555609 hasAuthorship W2891555609A5035788629 @default.
• W2891555609 hasAuthorship W2891555609A5081583597 @default.
• W2891555609 hasConcept C121332964 @default.
• W2891555609 hasConcept C121608353 @default.
• W2891555609 hasConcept C126322002 @default.
• W2891555609 hasConcept C141071460 @default.
• W2891555609 hasConcept C2777297899 @default.
• W2891555609 hasConcept C2777914695 @default.
• W2891555609 hasConcept C2778424827 @default.
• W2891555609 hasConcept C2779742542 @default.
• W2891555609 hasConcept C61434518 @default.
• W2891555609 hasConcept C61797465 @default.
• W2891555609 hasConcept C62520636 @default.
• W2891555609 hasConcept C71924100 @default.
• W2891555609 hasConceptScore W2891555609C121332964 @default.
• W2891555609 hasConceptScore W2891555609C121608353 @default.
• W2891555609 hasConceptScore W2891555609C126322002 @default.
• W2891555609 hasConceptScore W2891555609C141071460 @default.
• W2891555609 hasConceptScore W2891555609C2777297899 @default.
• W2891555609 hasConceptScore W2891555609C2777914695 @default.
• W2891555609 hasConceptScore W2891555609C2778424827 @default.
• W2891555609 hasConceptScore W2891555609C2779742542 @default.
• W2891555609 hasConceptScore W2891555609C61434518 @default.
• W2891555609 hasConceptScore W2891555609C61797465 @default.
• W2891555609 hasConceptScore W2891555609C62520636 @default.
• W2891555609 hasConceptScore W2891555609C71924100 @default.
• W2891555609 hasLocation W28915556091 @default.
• W2891555609 hasOpenAccess W2891555609 @default.
• W2891555609 hasPrimaryLocation W28915556091 @default.
• W2891555609 isParatext "false" @default.
• W2891555609 isRetracted "false" @default.
• W2891555609 magId "2891555609" @default.
• W2891555609 workType "article" @default.