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- W2891556282 abstract "Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on opioid receptors can cause a range of different effects such as changes in stress response, analgesia, motor activity and autonomic functions. This review provide a synthetic summary of the most recent literature on the use of drugs acting on mu-receptors to treat two prevalent functional bowel disorders, presenting with opposite bowel habit. Eluxadoline and naloxegol, methylnaltrexone and naldemedine are recently FDA and/or EMA approved drugs demonstrated to be effective and safe for treatment respectively of irritable bowel syndrome subtype diarrhea and opioid induced constipation." @default.
- W2891556282 created "2018-09-27" @default.
- W2891556282 creator A5081916513 @default.
- W2891556282 creator A5090043051 @default.
- W2891556282 date "2018-12-01" @default.
- W2891556282 modified "2023-10-18" @default.
- W2891556282 title "Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?" @default.
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- W2891556282 doi "https://doi.org/10.1016/j.coph.2018.08.008" @default.
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