FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891558510> ?p ?o ?g. }

• W2891558510 endingPage "2902" @default.
• W2891558510 startingPage "2889" @default.
• W2891558510 abstract "Aims Tacrolimus and mycophenolic acid dosing after renal transplantation is individualized through therapeutic drug monitoring (TDM). Home-based dried blood spot (DBS) sampling has the potential to replace conventional TDM sampling at the clinic. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed to quantify tacrolimus and mycophenolic acid in DBS and clinically validated for abbreviated area under the concentration-time curve (AUC) monitoring using an innovative volumetric DBS sampling device. Methods Clinical validation was performed by direct comparison of paired DBS and whole blood (WB) (tacrolimus) and plasma (mycophenolic acid) concentrations and AUCs. Agreement was evaluated using Passing-Bablok regression, Bland-Altman analysis and DBS-to-WB predictive performance. TDM dosing recommendations based on both methods were compared to assess clinical impact. Results Paired tacrolimus (n = 200) and mycophenolic acid (n = 192) DBS and WB samples were collected from 65 kidney(-pancreas) transplant recipients. Differences for tacrolimus and mycophenolic acid were within ±20% for 84.5% and 76.6% of concentrations and 90.5% and 90.7% of AUCs, respectively. Tacrolimus and mycophenolic acid dosing recommendation differences occurred on 44.4% and 4.7% of occasions. Tacrolimus DBS dosing recommendations were 0.35 ± 0.14 mg higher than for WB and 8 ± 3% of the initial dose. Mycophenolic acid DBS dosing recommendations were 23.3 ± 31.9 mg lower than for plasma and 2 ± 3.5% of the initial dose. Conclusions Tacrolimus and mycophenolic acid TDM for outpatient renal transplant recipients, based on abbreviated AUC collected with a DBS sampling device, is comparable to conventional TDM based on WB sampling. Patient training and guidance on good blood-spotting practices is essential to ensure method feasibility." @default.
• W2891558510 created "2018-09-27" @default.
• W2891558510 creator A5030957904 @default.
• W2891558510 creator A5033633380 @default.
• W2891558510 creator A5058166328 @default.
• W2891558510 creator A5058384202 @default.
• W2891558510 creator A5063768298 @default.
• W2891558510 creator A5063903295 @default.
• W2891558510 creator A5074552031 @default.
• W2891558510 creator A5076011340 @default.
• W2891558510 date "2018-10-15" @default.
• W2891558510 modified "2023-10-15" @default.
• W2891558510 title "Therapeutic drug monitoring of tacrolimus and mycophenolic acid in outpatient renal transplant recipients using a volumetric dried blood spot sampling device" @default.
• W2891558510 cites W1510950638 @default.
• W2891558510 cites W1913100467 @default.
• W2891558510 cites W1967741681 @default.
• W2891558510 cites W1978362461 @default.
• W2891558510 cites W1994502792 @default.
• W2891558510 cites W2001921235 @default.
• W2891558510 cites W2003143162 @default.
• W2891558510 cites W2007501521 @default.
• W2891558510 cites W2009251125 @default.
• W2891558510 cites W2015795623 @default.
• W2891558510 cites W2016307338 @default.
• W2891558510 cites W2019038379 @default.
• W2891558510 cites W2021554674 @default.
• W2891558510 cites W2023174165 @default.
• W2891558510 cites W2036008461 @default.
• W2891558510 cites W2042516926 @default.
• W2891558510 cites W2048601408 @default.
• W2891558510 cites W2049170691 @default.
• W2891558510 cites W2050071170 @default.
• W2891558510 cites W2065008398 @default.
• W2891558510 cites W2066128566 @default.
• W2891558510 cites W2068650301 @default.
• W2891558510 cites W2071146294 @default.
• W2891558510 cites W2071316125 @default.
• W2891558510 cites W2074354606 @default.
• W2891558510 cites W2075421237 @default.
• W2891558510 cites W2083191109 @default.
• W2891558510 cites W2094073838 @default.
• W2891558510 cites W2116604032 @default.
• W2891558510 cites W2118111820 @default.
• W2891558510 cites W2119227173 @default.
• W2891558510 cites W2122406380 @default.
• W2891558510 cites W2142102659 @default.
• W2891558510 cites W2155965977 @default.
• W2891558510 cites W2178904520 @default.
• W2891558510 cites W2198265901 @default.
• W2891558510 cites W2277250804 @default.
• W2891558510 cites W2290951021 @default.
• W2891558510 cites W2307721485 @default.
• W2891558510 cites W2321574814 @default.
• W2891558510 cites W2470198077 @default.
• W2891558510 cites W2557892362 @default.
• W2891558510 cites W2564094638 @default.
• W2891558510 cites W2567308162 @default.
• W2891558510 cites W2595095683 @default.
• W2891558510 cites W2734444589 @default.
• W2891558510 cites W2752699676 @default.
• W2891558510 cites W2755160706 @default.
• W2891558510 cites W2767557583 @default.
• W2891558510 cites W2771328536 @default.
• W2891558510 cites W2771413423 @default.
• W2891558510 cites W2779439162 @default.
• W2891558510 cites W4211117577 @default.
• W2891558510 doi "https://doi.org/10.1111/bcp.13755" @default.
• W2891558510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6256056" @default.
• W2891558510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30176064" @default.
• W2891558510 hasPublicationYear "2018" @default.
• W2891558510 type Work @default.
• W2891558510 sameAs 2891558510 @default.
• W2891558510 citedByCount "65" @default.
• W2891558510 countsByYear W28915585102019 @default.
• W2891558510 countsByYear W28915585102020 @default.
• W2891558510 countsByYear W28915585102021 @default.
• W2891558510 countsByYear W28915585102022 @default.
• W2891558510 countsByYear W28915585102023 @default.
• W2891558510 crossrefType "journal-article" @default.
• W2891558510 hasAuthorship W2891558510A5030957904 @default.
• W2891558510 hasAuthorship W2891558510A5033633380 @default.
• W2891558510 hasAuthorship W2891558510A5058166328 @default.
• W2891558510 hasAuthorship W2891558510A5058384202 @default.
• W2891558510 hasAuthorship W2891558510A5063768298 @default.
• W2891558510 hasAuthorship W2891558510A5063903295 @default.
• W2891558510 hasAuthorship W2891558510A5074552031 @default.
• W2891558510 hasAuthorship W2891558510A5076011340 @default.
• W2891558510 hasBestOaLocation W28915585101 @default.
• W2891558510 hasConcept C106131492 @default.
• W2891558510 hasConcept C126322002 @default.
• W2891558510 hasConcept C126894567 @default.
• W2891558510 hasConcept C140779682 @default.
• W2891558510 hasConcept C185592680 @default.
• W2891558510 hasConcept C2776597655 @default.
• W2891558510 hasConcept C2778033501 @default.
• W2891558510 hasConcept C2780035454 @default.
• W2891558510 hasConcept C2780272996 @default.
• W2891558510 hasConcept C2780303639 @default.

• next