Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891558623> ?p ?o ?g. }
- W2891558623 endingPage "261" @default.
- W2891558623 startingPage "254" @default.
- W2891558623 abstract "The pro-apoptotic role of Protein kinase Cδ (PKCδ), a member of the novel PKC subfamily, has been well-documented in various pathological conditions. In the central nervous system, the possible role of PKCδ has been studied, mainly in the condition of dopaminergic loss. It has been suggested that the phosphorylation of PKCδ at tyrosine 311 residue (Tyr311) by redox-sensitive Src family kinases (SFKs) is critical for the caspase-3-mediated proteolytic cleavage, which produces the constitutively active cleaved form of PKCδ. Mitochondrial translocation of cleaved PKCδ has been suggested to facilitate mitochondria-derived apoptosis and oxidative burdens. Moreover, it has been suggested that PKCδ contribute to neuroinflammation through the transformation of microglia into the pro-inflammatory M1 phenotype and the assembly of membrane NADPH oxidase in dopaminergic impairments. Interestingly, mitochondrial respiratory chain inhibitors or neuroinflammogens have shown to induce PKCδ activation in dopaminergic systems. Thus, PKCδ activation may be one of the pivotal causes of neuropathologic events, and could amplify these processes further in a positive feedback manner. Furthermore, PKCδ may play an intermediary role in connecting each neuropathologic event. This review affords insight into the role of PKCδ in various dopaminergic neurotoxic models, which could provide a potential target for mitigating dopaminergic neurotoxicity." @default.
- W2891558623 created "2018-09-27" @default.
- W2891558623 creator A5006545170 @default.
- W2891558623 creator A5010710813 @default.
- W2891558623 creator A5022875432 @default.
- W2891558623 creator A5025941714 @default.
- W2891558623 creator A5037191128 @default.
- W2891558623 creator A5037985631 @default.
- W2891558623 creator A5055747865 @default.
- W2891558623 creator A5057133143 @default.
- W2891558623 creator A5067939590 @default.
- W2891558623 creator A5083625738 @default.
- W2891558623 date "2018-11-01" @default.
- W2891558623 modified "2023-10-16" @default.
- W2891558623 title "Role of protein kinase Cδ in dopaminergic neurotoxic events" @default.
- W2891558623 cites W1567934634 @default.
- W2891558623 cites W1667616536 @default.
- W2891558623 cites W1938380786 @default.
- W2891558623 cites W1947879644 @default.
- W2891558623 cites W1965347832 @default.
- W2891558623 cites W1967067593 @default.
- W2891558623 cites W1968543969 @default.
- W2891558623 cites W1969116899 @default.
- W2891558623 cites W1970722898 @default.
- W2891558623 cites W1971167579 @default.
- W2891558623 cites W1972386798 @default.
- W2891558623 cites W1977802043 @default.
- W2891558623 cites W1979107664 @default.
- W2891558623 cites W1982066557 @default.
- W2891558623 cites W1982396527 @default.
- W2891558623 cites W1982644516 @default.
- W2891558623 cites W1987528275 @default.
- W2891558623 cites W1988994868 @default.
- W2891558623 cites W1990509075 @default.
- W2891558623 cites W1993720756 @default.
- W2891558623 cites W1994429692 @default.
- W2891558623 cites W1995990276 @default.
- W2891558623 cites W1999046788 @default.
- W2891558623 cites W1999922500 @default.
- W2891558623 cites W2000586934 @default.
- W2891558623 cites W2012311232 @default.
- W2891558623 cites W2012428372 @default.
- W2891558623 cites W2013026308 @default.
- W2891558623 cites W2015571904 @default.
- W2891558623 cites W2017245822 @default.
- W2891558623 cites W2024050535 @default.
- W2891558623 cites W2027259173 @default.
- W2891558623 cites W2027387545 @default.
- W2891558623 cites W2029475270 @default.
- W2891558623 cites W2030558096 @default.
- W2891558623 cites W2031941812 @default.
- W2891558623 cites W2032219214 @default.
- W2891558623 cites W2035672058 @default.
- W2891558623 cites W2039988178 @default.
- W2891558623 cites W2040508879 @default.
- W2891558623 cites W2046425161 @default.
- W2891558623 cites W2046762377 @default.
- W2891558623 cites W2046967306 @default.
- W2891558623 cites W2050327248 @default.
- W2891558623 cites W2053071718 @default.
- W2891558623 cites W2053505746 @default.
- W2891558623 cites W2055308573 @default.
- W2891558623 cites W2057451803 @default.
- W2891558623 cites W2057737664 @default.
- W2891558623 cites W2058983867 @default.
- W2891558623 cites W2059526312 @default.
- W2891558623 cites W2060513486 @default.
- W2891558623 cites W2060666628 @default.
- W2891558623 cites W2061364450 @default.
- W2891558623 cites W2062116891 @default.
- W2891558623 cites W2063160236 @default.
- W2891558623 cites W2069802098 @default.
- W2891558623 cites W2072916675 @default.
- W2891558623 cites W2073777605 @default.
- W2891558623 cites W2073802968 @default.
- W2891558623 cites W2073822700 @default.
- W2891558623 cites W2074346842 @default.
- W2891558623 cites W2076743846 @default.
- W2891558623 cites W2077665447 @default.
- W2891558623 cites W2086194421 @default.
- W2891558623 cites W2086357928 @default.
- W2891558623 cites W2090030850 @default.
- W2891558623 cites W2090547982 @default.
- W2891558623 cites W2091355219 @default.
- W2891558623 cites W2092043203 @default.
- W2891558623 cites W2092780698 @default.
- W2891558623 cites W2095421389 @default.
- W2891558623 cites W2102421517 @default.
- W2891558623 cites W2104367467 @default.
- W2891558623 cites W2104969843 @default.
- W2891558623 cites W2119098545 @default.
- W2891558623 cites W2126681184 @default.
- W2891558623 cites W2131613604 @default.
- W2891558623 cites W2133037422 @default.
- W2891558623 cites W2144013732 @default.
- W2891558623 cites W2161456562 @default.
- W2891558623 cites W2162807163 @default.
- W2891558623 cites W2167236182 @default.