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• W2891560139 abstract "Breast cancer (BC) is the leading cancer affecting Chinese women; however, the immune microenvironment between molecular subtypes is less reported. This study aimed to investigate the distribution of tumor-infiltrating lymphocyte (TIL) subpopulations, especially exhausted CD4+ and CD8+ TILs in Chinese BC patients.A total of 133 patients with breast invasive ductal carcinoma were recruited consecutively from January 1, 2012 to December 31, 2013, and TILs were detected in H&E-stained sections. Expression profiling of PD-1, CD4, and CD8 was determined by immunohistochemistry on 4 µm formalin-fixed paraffin-embedded tissue sections. The distribution of TILs was analyzed based on hormone receptor status and molecular subtypes.PD-1+, CD4+, and CD8+ TILs distributed differently based on molecular subtypes. Compared to Luminal A, triple-negative breast cancer (TNBC) patients had more PD-1+ TILs (39/high-power field [HPF] vs 11/HPF), PD-1+ helper T (CD4+) cells (28/HPF vs 10/HPF), and PD-1+ cytotoxic (CD8+) T-cells (3/HPF vs 2/HPF).TILs are distributed differently based on molecular subtypes. TNBC patients exhibit more PD-1+ exhausted TILs, representing an inhibitory immune microenvironment. PD-1/PD-L1 pathway is a potential therapeutic target of TNBC." @default.
• W2891560139 created "2018-09-27" @default.
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• W2891560139 date "2018-09-01" @default.
• W2891560139 modified "2023-10-17" @default.
• W2891560139 title "Distribution of CD4⁺ and CD8⁺ exhausted tumor-infiltrating lymphocytes in molecular subtypes of Chinese breast cancer patients" @default.
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• W2891560139 doi "https://doi.org/10.2147/ott.s168057" @default.
• W2891560139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160273" @default.
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