FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891561968> ?p ?o ?g. }

• W2891561968 abstract "Natural anion channelrhodopsins (ACRs) have recently received increased attention because of their effectiveness in optogenetic manipulation for neuronal silencing. In this study, we focused on Proteomonas sulcata ACR1 (PsuACR1), which has rapid channel closing kinetics and a rapid recovery to the initial state of its anion channel function that is useful for rapid optogenetic control. To reveal the anion concentration dependency of the channel function, we investigated the photochemical properties of PsuACR1 using spectroscopic techniques. Recombinant PsuACR1 exhibited a Cl- dependent spectral red-shift from 531 nm at 0.1 mM to 535 nm at 1000 mM, suggesting that it binds Cl- in the initial state with a Kd of 5.5 mM. Flash-photolysis experiments revealed that the photocycle was significantly changed at high Cl- concentrations, which led not only to suppression of the accumulation of the M-intermediate involved in the Cl- non-conducting state but also to a drastic change in the equilibrium state of the other photo-intermediates. Because of this, the Cl- conducting state is protracted by one order of magnitude, which implies an impairment of the rapid channel closing of PsuACR1 in the presence of high concentrations of Cl-." @default.
• W2891561968 created "2018-09-27" @default.
• W2891561968 creator A5004819222 @default.
• W2891561968 creator A5021912526 @default.
• W2891561968 creator A5057541087 @default.
• W2891561968 creator A5064856279 @default.
• W2891561968 creator A5072022943 @default.
• W2891561968 creator A5088528790 @default.
• W2891561968 date "2018-09-07" @default.
• W2891561968 modified "2023-10-16" @default.
• W2891561968 title "Implications for the impairment of the rapid channel closing of Proteomonas sulcata anion channelrhodopsin 1 at high Cl− concentrations" @default.
• W2891561968 cites W1603724361 @default.
• W2891561968 cites W1788106766 @default.
• W2891561968 cites W1841134268 @default.
• W2891561968 cites W1897978787 @default.
• W2891561968 cites W1965199972 @default.
• W2891561968 cites W1987362159 @default.
• W2891561968 cites W2003011987 @default.
• W2891561968 cites W2007158665 @default.
• W2891561968 cites W2014745838 @default.
• W2891561968 cites W2019938384 @default.
• W2891561968 cites W2021579729 @default.
• W2891561968 cites W2036035836 @default.
• W2891561968 cites W2038406108 @default.
• W2891561968 cites W2049852872 @default.
• W2891561968 cites W2056805267 @default.
• W2891561968 cites W2058082904 @default.
• W2891561968 cites W2062594525 @default.
• W2891561968 cites W2074089338 @default.
• W2891561968 cites W2077727377 @default.
• W2891561968 cites W2085047362 @default.
• W2891561968 cites W2089634204 @default.
• W2891561968 cites W2110415094 @default.
• W2891561968 cites W2111421954 @default.
• W2891561968 cites W2118640248 @default.
• W2891561968 cites W2218208517 @default.
• W2891561968 cites W2235506763 @default.
• W2891561968 cites W2305801173 @default.
• W2891561968 cites W2319709822 @default.
• W2891561968 cites W2326312316 @default.
• W2891561968 cites W2540771181 @default.
• W2891561968 cites W2585129846 @default.
• W2891561968 cites W2588963194 @default.
• W2891561968 cites W2592900641 @default.
• W2891561968 cites W2593902424 @default.
• W2891561968 cites W2602118939 @default.
• W2891561968 cites W2766660411 @default.
• W2891561968 cites W2769947821 @default.
• W2891561968 cites W2787687110 @default.
• W2891561968 cites W2793571793 @default.
• W2891561968 cites W2810804251 @default.
• W2891561968 cites W846101613 @default.
• W2891561968 doi "https://doi.org/10.1038/s41598-018-31742-6" @default.
• W2891561968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128917" @default.
• W2891561968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194401" @default.
• W2891561968 hasPublicationYear "2018" @default.
• W2891561968 type Work @default.
• W2891561968 sameAs 2891561968 @default.
• W2891561968 citedByCount "3" @default.
• W2891561968 countsByYear W28915619682020 @default.
• W2891561968 countsByYear W28915619682021 @default.
• W2891561968 crossrefType "journal-article" @default.
• W2891561968 hasAuthorship W2891561968A5004819222 @default.
• W2891561968 hasAuthorship W2891561968A5021912526 @default.
• W2891561968 hasAuthorship W2891561968A5057541087 @default.
• W2891561968 hasAuthorship W2891561968A5064856279 @default.
• W2891561968 hasAuthorship W2891561968A5072022943 @default.
• W2891561968 hasAuthorship W2891561968A5088528790 @default.
• W2891561968 hasBestOaLocation W28915619681 @default.
• W2891561968 hasConcept C121332964 @default.
• W2891561968 hasConcept C12554922 @default.
• W2891561968 hasConcept C13472781 @default.
• W2891561968 hasConcept C145148216 @default.
• W2891561968 hasConcept C148898269 @default.
• W2891561968 hasConcept C169760540 @default.
• W2891561968 hasConcept C170493617 @default.
• W2891561968 hasConcept C17744445 @default.
• W2891561968 hasConcept C178790620 @default.
• W2891561968 hasConcept C185592680 @default.
• W2891561968 hasConcept C199539241 @default.
• W2891561968 hasConcept C2778775528 @default.
• W2891561968 hasConcept C37218471 @default.
• W2891561968 hasConcept C50254741 @default.
• W2891561968 hasConcept C50738837 @default.
• W2891561968 hasConcept C55493867 @default.
• W2891561968 hasConcept C62520636 @default.
• W2891561968 hasConcept C75473681 @default.
• W2891561968 hasConcept C86803240 @default.
• W2891561968 hasConcept C93391505 @default.
• W2891561968 hasConceptScore W2891561968C121332964 @default.
• W2891561968 hasConceptScore W2891561968C12554922 @default.
• W2891561968 hasConceptScore W2891561968C13472781 @default.
• W2891561968 hasConceptScore W2891561968C145148216 @default.
• W2891561968 hasConceptScore W2891561968C148898269 @default.
• W2891561968 hasConceptScore W2891561968C169760540 @default.
• W2891561968 hasConceptScore W2891561968C170493617 @default.
• W2891561968 hasConceptScore W2891561968C17744445 @default.
• W2891561968 hasConceptScore W2891561968C178790620 @default.
• W2891561968 hasConceptScore W2891561968C185592680 @default.
• W2891561968 hasConceptScore W2891561968C199539241 @default.

• next