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- W2891562743 abstract "Cushing’s syndrome due to bilateral adrenal hyperplasia is a rare disease with a high morbidity and mortality rate. The hypercortisolism found in Cushing’s syndrome leads to obesity and its associated diseases, higher risk of infections, and conditions associated with collagen breakdown. Surgical resection of the source of cortisol is curative but results in a patient with permanent adrenal insufficiency and the need for life-long medications. Bilateral adrenalectomy has been the standard treatment, but a unilateral adrenalectomy has provided good outcomes and reduces the chance of life-long hypoadrenalism. Laparscopic and synchronous removal of the adrenal glands has offered a cure with less complications and morbidity. Medical therapies decrease cortisol production by inhibiting ACTH, inhibiting cortisol, or blocking the action of cortisol at the level of the glucocorticoid receptor. Combination medical therapy can offer faster improvement in cortisol levels. The following chapter reviews the benefits and risks of surgical versus medical therapy in patients with Cushing’s syndrome due to bilateral adrenal hyperplasia." @default.
- W2891562743 created "2018-09-27" @default.
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- W2891562743 date "2018-01-01" @default.
- W2891562743 modified "2023-09-25" @default.
- W2891562743 title "Bilateral Adrenalectomy Versus Medical Management for Cushing’s Syndrome with Bilateral Adrenal Hyperplasia" @default.
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- W2891562743 doi "https://doi.org/10.1007/978-3-319-92860-9_26" @default.
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