Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891562908> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2891562908 endingPage "e135" @default.
- W2891562908 startingPage "e135" @default.
- W2891562908 abstract "Epidermis, the surface layer of human skin, is formed by cells called keratinocytes. They divide (making more cells) in the deeper parts of the skin and gradually move towards the surface. Keratinocytes eventually form a layer of dead cells on the skin's surface, and this layer is the main protective barrier against things that might damage or irritate the skin, such as chemicals and germs. A viscous substance called hyaluronan surrounds keratinocytes in the lower, living cell layers. All kinds of injuries to the epidermis, like wounding, infection, and sunburn, trigger a strong inflammatory response by keratinocytes. This response includes increased division of keratinocytes, and their movement to help the injury site recover, as well as increased hyaluronan production and turnover. In many skin diseases the keratinocyte injury‐response is excessive, or even completely unfounded, and harmful. Therefore, factors and treatments that calm down this reaction are potential medicines for some skin diseases. This study from Kuopio, Finland, studied hyaluronan metabolism (i.e. breakdown) in a special model developed in the laboratory, in which keratinocytes separate to produce a normal‐looking epidermis. This model allowed the researchers to demonstrate that vitamin C suppresses both production and degradation of hyaluronan in the epidermis. Since rapid hyaluronan metabolism is an indicator of inflammation, vitamin C – which is an antioxidant ‐ might have a use for suppressing this reaction in keratinocytes. This study calls for more work on the vitamin's mechanism of action, and possible roles in clinical practice." @default.
- W2891562908 created "2018-09-27" @default.
- W2891562908 creator A5017235634 @default.
- W2891562908 creator A5018214632 @default.
- W2891562908 creator A5024772304 @default.
- W2891562908 creator A5046108220 @default.
- W2891562908 creator A5060975794 @default.
- W2891562908 creator A5061104516 @default.
- W2891562908 creator A5065361581 @default.
- W2891562908 creator A5069533486 @default.
- W2891562908 creator A5082176270 @default.
- W2891562908 creator A5088605616 @default.
- W2891562908 date "2018-09-01" @default.
- W2891562908 modified "2023-10-13" @default.
- W2891562908 title "Epidermal maturation, vitamin C and hyaluronan metabolism" @default.
- W2891562908 doi "https://doi.org/10.1111/bjd.17041" @default.
- W2891562908 hasPublicationYear "2018" @default.
- W2891562908 type Work @default.
- W2891562908 sameAs 2891562908 @default.
- W2891562908 citedByCount "0" @default.
- W2891562908 crossrefType "journal-article" @default.
- W2891562908 hasAuthorship W2891562908A5017235634 @default.
- W2891562908 hasAuthorship W2891562908A5018214632 @default.
- W2891562908 hasAuthorship W2891562908A5024772304 @default.
- W2891562908 hasAuthorship W2891562908A5046108220 @default.
- W2891562908 hasAuthorship W2891562908A5060975794 @default.
- W2891562908 hasAuthorship W2891562908A5061104516 @default.
- W2891562908 hasAuthorship W2891562908A5065361581 @default.
- W2891562908 hasAuthorship W2891562908A5069533486 @default.
- W2891562908 hasAuthorship W2891562908A5082176270 @default.
- W2891562908 hasAuthorship W2891562908A5088605616 @default.
- W2891562908 hasBestOaLocation W28915629081 @default.
- W2891562908 hasConcept C105702510 @default.
- W2891562908 hasConcept C185592680 @default.
- W2891562908 hasConcept C202751555 @default.
- W2891562908 hasConcept C203014093 @default.
- W2891562908 hasConcept C2776458125 @default.
- W2891562908 hasConcept C2776914184 @default.
- W2891562908 hasConcept C2777074287 @default.
- W2891562908 hasConcept C2777459323 @default.
- W2891562908 hasConcept C2777529286 @default.
- W2891562908 hasConcept C54355233 @default.
- W2891562908 hasConcept C55493867 @default.
- W2891562908 hasConcept C71924100 @default.
- W2891562908 hasConcept C86803240 @default.
- W2891562908 hasConcept C95444343 @default.
- W2891562908 hasConceptScore W2891562908C105702510 @default.
- W2891562908 hasConceptScore W2891562908C185592680 @default.
- W2891562908 hasConceptScore W2891562908C202751555 @default.
- W2891562908 hasConceptScore W2891562908C203014093 @default.
- W2891562908 hasConceptScore W2891562908C2776458125 @default.
- W2891562908 hasConceptScore W2891562908C2776914184 @default.
- W2891562908 hasConceptScore W2891562908C2777074287 @default.
- W2891562908 hasConceptScore W2891562908C2777459323 @default.
- W2891562908 hasConceptScore W2891562908C2777529286 @default.
- W2891562908 hasConceptScore W2891562908C54355233 @default.
- W2891562908 hasConceptScore W2891562908C55493867 @default.
- W2891562908 hasConceptScore W2891562908C71924100 @default.
- W2891562908 hasConceptScore W2891562908C86803240 @default.
- W2891562908 hasConceptScore W2891562908C95444343 @default.
- W2891562908 hasIssue "3" @default.
- W2891562908 hasLocation W28915629081 @default.
- W2891562908 hasOpenAccess W2891562908 @default.
- W2891562908 hasPrimaryLocation W28915629081 @default.
- W2891562908 hasRelatedWork W1964045634 @default.
- W2891562908 hasRelatedWork W2021274172 @default.
- W2891562908 hasRelatedWork W2022368774 @default.
- W2891562908 hasRelatedWork W2030037941 @default.
- W2891562908 hasRelatedWork W2034305425 @default.
- W2891562908 hasRelatedWork W2078136797 @default.
- W2891562908 hasRelatedWork W2753404734 @default.
- W2891562908 hasRelatedWork W2950793995 @default.
- W2891562908 hasRelatedWork W4254071914 @default.
- W2891562908 hasRelatedWork W53918861 @default.
- W2891562908 hasVolume "179" @default.
- W2891562908 isParatext "false" @default.
- W2891562908 isRetracted "false" @default.
- W2891562908 magId "2891562908" @default.
- W2891562908 workType "article" @default.