Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891569810> ?p ?o ?g. }
- W2891569810 endingPage "3668" @default.
- W2891569810 startingPage "3668" @default.
- W2891569810 abstract "Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae subfamily that together with the β- and γ-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 A using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify α-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability." @default.
- W2891569810 created "2018-09-27" @default.
- W2891569810 creator A5017525793 @default.
- W2891569810 creator A5027307547 @default.
- W2891569810 creator A5031402632 @default.
- W2891569810 creator A5050311121 @default.
- W2891569810 creator A5052080961 @default.
- W2891569810 creator A5054610529 @default.
- W2891569810 creator A5056028884 @default.
- W2891569810 creator A5065531732 @default.
- W2891569810 creator A5070105705 @default.
- W2891569810 creator A5073898745 @default.
- W2891569810 creator A5078746987 @default.
- W2891569810 creator A5079181258 @default.
- W2891569810 date "2018-09-10" @default.
- W2891569810 modified "2023-10-11" @default.
- W2891569810 title "Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component" @default.
- W2891569810 cites W1485681295 @default.
- W2891569810 cites W1914632942 @default.
- W2891569810 cites W1965469087 @default.
- W2891569810 cites W1983591461 @default.
- W2891569810 cites W1998643471 @default.
- W2891569810 cites W1999985873 @default.
- W2891569810 cites W2006158980 @default.
- W2891569810 cites W2065377000 @default.
- W2891569810 cites W2066234978 @default.
- W2891569810 cites W2075824676 @default.
- W2891569810 cites W2078627064 @default.
- W2891569810 cites W2081492015 @default.
- W2891569810 cites W2082444144 @default.
- W2891569810 cites W2086466935 @default.
- W2891569810 cites W2104234755 @default.
- W2891569810 cites W2108518323 @default.
- W2891569810 cites W2118521722 @default.
- W2891569810 cites W2119489910 @default.
- W2891569810 cites W2125511222 @default.
- W2891569810 cites W2132629607 @default.
- W2891569810 cites W2144081223 @default.
- W2891569810 cites W2148869484 @default.
- W2891569810 cites W2149360962 @default.
- W2891569810 cites W2149476505 @default.
- W2891569810 cites W2150052212 @default.
- W2891569810 cites W2154197653 @default.
- W2891569810 cites W2154714625 @default.
- W2891569810 cites W2158897346 @default.
- W2891569810 cites W2166560113 @default.
- W2891569810 cites W2169222163 @default.
- W2891569810 cites W2339100178 @default.
- W2891569810 cites W2344899240 @default.
- W2891569810 cites W2604150127 @default.
- W2891569810 cites W2608710764 @default.
- W2891569810 cites W2732446419 @default.
- W2891569810 cites W2784002879 @default.
- W2891569810 cites W2793746691 @default.
- W2891569810 cites W2794757315 @default.
- W2891569810 cites W2795843171 @default.
- W2891569810 cites W2796156307 @default.
- W2891569810 cites W2801961940 @default.
- W2891569810 cites W2950967305 @default.
- W2891569810 cites W46881500 @default.
- W2891569810 doi "https://doi.org/10.2210/pdb5zz8/pdb" @default.
- W2891569810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131487" @default.
- W2891569810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30201968" @default.
- W2891569810 hasPublicationYear "2018" @default.
- W2891569810 type Work @default.
- W2891569810 sameAs 2891569810 @default.
- W2891569810 citedByCount "11" @default.
- W2891569810 countsByYear W28915698102019 @default.
- W2891569810 countsByYear W28915698102020 @default.
- W2891569810 countsByYear W28915698102021 @default.
- W2891569810 countsByYear W28915698102022 @default.
- W2891569810 countsByYear W28915698102023 @default.
- W2891569810 crossrefType "component" @default.
- W2891569810 hasAuthorship W2891569810A5017525793 @default.
- W2891569810 hasAuthorship W2891569810A5027307547 @default.
- W2891569810 hasAuthorship W2891569810A5031402632 @default.
- W2891569810 hasAuthorship W2891569810A5050311121 @default.
- W2891569810 hasAuthorship W2891569810A5052080961 @default.
- W2891569810 hasAuthorship W2891569810A5054610529 @default.
- W2891569810 hasAuthorship W2891569810A5056028884 @default.
- W2891569810 hasAuthorship W2891569810A5065531732 @default.
- W2891569810 hasAuthorship W2891569810A5070105705 @default.
- W2891569810 hasAuthorship W2891569810A5073898745 @default.
- W2891569810 hasAuthorship W2891569810A5078746987 @default.
- W2891569810 hasAuthorship W2891569810A5079181258 @default.
- W2891569810 hasBestOaLocation W28915698101 @default.
- W2891569810 hasConcept C104292427 @default.
- W2891569810 hasConcept C104317684 @default.
- W2891569810 hasConcept C132525143 @default.
- W2891569810 hasConcept C159047783 @default.
- W2891569810 hasConcept C178790620 @default.
- W2891569810 hasConcept C185592680 @default.
- W2891569810 hasConcept C202878990 @default.
- W2891569810 hasConcept C2522874641 @default.
- W2891569810 hasConcept C2779546866 @default.
- W2891569810 hasConcept C2781196997 @default.
- W2891569810 hasConcept C41008148 @default.
- W2891569810 hasConcept C54355233 @default.