FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891570004> ?p ?o ?g. }

• W2891570004 abstract "Abstract Mitohormesis is an adaptive response induced by a mild mitochondrial stress that promotes longevity and metabolic health in different organisms. This mechanism has been proposed as the cause of the increase in the survival in Coq7 +/− ( Mclk1 +/− ) mice, which show hepatic reduction of COQ7, early mitochondrial dysfunction and increased oxidative stress. Our study shows that the lack of COQ9 in Coq9 Q95X mice triggers the reduction of COQ7, COQ6 and COQ5, which results in an increase in life expectancy. However, our results reveal that the hepatic CoQ levels are not decreased and, therefore, neither mitochondrial dysfunction or increased oxidative stress are observed in liver of Coq9 Q95X mice. These data point out the tissue specific differences in CoQ biosynthesis. Moreover, our results suggest that the effect of reduced levels of COQ7 on the increased survival in Coq9 Q95X mice may be due to mitochondrial mechanisms in non-liver tissues or to other unknown mechanisms." @default.
• W2891570004 created "2018-09-27" @default.
• W2891570004 creator A5007383535 @default.
• W2891570004 creator A5017041542 @default.
• W2891570004 creator A5025605180 @default.
• W2891570004 creator A5031658908 @default.
• W2891570004 creator A5038771061 @default.
• W2891570004 creator A5062208123 @default.
• W2891570004 creator A5074496095 @default.
• W2891570004 creator A5081280604 @default.
• W2891570004 creator A5090157656 @default.
• W2891570004 date "2018-09-18" @default.
• W2891570004 modified "2023-10-17" @default.
• W2891570004 title "Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis" @default.
• W2891570004 cites W1201649467 @default.
• W2891570004 cites W1616682748 @default.
• W2891570004 cites W1960615704 @default.
• W2891570004 cites W1972025146 @default.
• W2891570004 cites W1978336416 @default.
• W2891570004 cites W1979705609 @default.
• W2891570004 cites W1983106336 @default.
• W2891570004 cites W1986003236 @default.
• W2891570004 cites W2005381354 @default.
• W2891570004 cites W2007636933 @default.
• W2891570004 cites W2021460489 @default.
• W2891570004 cites W2021786783 @default.
• W2891570004 cites W2023147388 @default.
• W2891570004 cites W2039340367 @default.
• W2891570004 cites W2049516586 @default.
• W2891570004 cites W2063087581 @default.
• W2891570004 cites W2068337326 @default.
• W2891570004 cites W2075980391 @default.
• W2891570004 cites W2090373595 @default.
• W2891570004 cites W2093336696 @default.
• W2891570004 cites W2095389529 @default.
• W2891570004 cites W2099857213 @default.
• W2891570004 cites W2102629981 @default.
• W2891570004 cites W2106782271 @default.
• W2891570004 cites W2126525177 @default.
• W2891570004 cites W2132438126 @default.
• W2891570004 cites W2142353558 @default.
• W2891570004 cites W2153091014 @default.
• W2891570004 cites W2168744563 @default.
• W2891570004 cites W2295446846 @default.
• W2891570004 cites W2315512556 @default.
• W2891570004 cites W2471519258 @default.
• W2891570004 cites W2520711929 @default.
• W2891570004 cites W254181049 @default.
• W2891570004 cites W2552817330 @default.
• W2891570004 cites W2605040491 @default.
• W2891570004 cites W2617193312 @default.
• W2891570004 cites W4231604814 @default.
• W2891570004 cites W4238260078 @default.
• W2891570004 doi "https://doi.org/10.1038/s41598-018-32190-y" @default.
• W2891570004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143522" @default.
• W2891570004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30228311" @default.
• W2891570004 hasPublicationYear "2018" @default.
• W2891570004 type Work @default.
• W2891570004 sameAs 2891570004 @default.
• W2891570004 citedByCount "9" @default.
• W2891570004 countsByYear W28915700042019 @default.
• W2891570004 countsByYear W28915700042021 @default.
• W2891570004 countsByYear W28915700042023 @default.
• W2891570004 crossrefType "journal-article" @default.
• W2891570004 hasAuthorship W2891570004A5007383535 @default.
• W2891570004 hasAuthorship W2891570004A5017041542 @default.
• W2891570004 hasAuthorship W2891570004A5025605180 @default.
• W2891570004 hasAuthorship W2891570004A5031658908 @default.
• W2891570004 hasAuthorship W2891570004A5038771061 @default.
• W2891570004 hasAuthorship W2891570004A5062208123 @default.
• W2891570004 hasAuthorship W2891570004A5074496095 @default.
• W2891570004 hasAuthorship W2891570004A5081280604 @default.
• W2891570004 hasAuthorship W2891570004A5090157656 @default.
• W2891570004 hasBestOaLocation W28915700041 @default.
• W2891570004 hasConcept C126322002 @default.
• W2891570004 hasConcept C133925201 @default.
• W2891570004 hasConcept C134018914 @default.
• W2891570004 hasConcept C2776151105 @default.
• W2891570004 hasConcept C2776759703 @default.
• W2891570004 hasConcept C28859421 @default.
• W2891570004 hasConcept C2908647359 @default.
• W2891570004 hasConcept C54355233 @default.
• W2891570004 hasConcept C55493867 @default.
• W2891570004 hasConcept C57600042 @default.
• W2891570004 hasConcept C71924100 @default.
• W2891570004 hasConcept C86803240 @default.
• W2891570004 hasConcept C99454951 @default.
• W2891570004 hasConceptScore W2891570004C126322002 @default.
• W2891570004 hasConceptScore W2891570004C133925201 @default.
• W2891570004 hasConceptScore W2891570004C134018914 @default.
• W2891570004 hasConceptScore W2891570004C2776151105 @default.
• W2891570004 hasConceptScore W2891570004C2776759703 @default.
• W2891570004 hasConceptScore W2891570004C28859421 @default.
• W2891570004 hasConceptScore W2891570004C2908647359 @default.
• W2891570004 hasConceptScore W2891570004C54355233 @default.
• W2891570004 hasConceptScore W2891570004C55493867 @default.
• W2891570004 hasConceptScore W2891570004C57600042 @default.
• W2891570004 hasConceptScore W2891570004C71924100 @default.
• W2891570004 hasConceptScore W2891570004C86803240 @default.
• W2891570004 hasConceptScore W2891570004C99454951 @default.

• next