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- W2891575072 abstract "It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates sirtuin and enhances mitochondrial redox regulation, but the exact mechanisms are still under debate. In this review, we discuss the mechanisms of CR using evidence from studies of animals that were genetically modified according to recent advances in molecular and genetic technologies, from the viewpoint of the adaptive response hypothesis proposed by Holliday (1989). We then explain the beneficial actions of CR, classified according to whether they operate under feeding or fasting conditions." @default.
- W2891575072 created "2018-09-27" @default.
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- W2891575072 date "2018-09-16" @default.
- W2891575072 modified "2023-09-30" @default.
- W2891575072 title "Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals" @default.
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- W2891575072 doi "https://doi.org/10.18632/aging.101557" @default.
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