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- W2891578687 endingPage "334" @default.
- W2891578687 startingPage "289" @default.
- W2891578687 abstract "Human thyroid development is recapitulated in murine models that have significantly contributed to understanding thyroid morphogenesis. The thyroid gland maintains a concentration of free iodide 20–40 times higher than that of plasma under physiological conditions and iodide uptake occurs across the basolateral membrane of the thyroid follicular cell via the sodium–iodide symporter encoded by SLC5A5. As well as stimulating positive regulation of thyroid hormone biosynthesis, a sensitive negative feedback mechanism operates within the hypothalamic–pituitary–thyroid axis. This enables circulating concentrations of thyroid hormones to be maintained within an individually unique set point within a population reference range. The chapter discusses clinical thyroid disorders and diagnostic pitfalls. Screening for congenital hypothyroidism has been a significant public health success with near elimination of cretinism where introduced. Infants diagnosed with CH should be treated immediately with the aim of rapidly normalizing thyroid function." @default.
- W2891578687 created "2018-09-27" @default.
- W2891578687 creator A5006665690 @default.
- W2891578687 creator A5076852830 @default.
- W2891578687 date "2019-08-30" @default.
- W2891578687 modified "2023-09-27" @default.
- W2891578687 title "The Thyroid Gland" @default.
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