Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891582920> ?p ?o ?g. }
- W2891582920 abstract "Abstract Exogenous metabolites from microbial and dietary origins have profound effects on host metabolism. Here, we report that a sub-population of lipid droplets (LDs), which are conserved organelles for fat storage, is defined by metabolites-driven targeting of the C. elegans seipin ortholog, SEIP-1. Loss of SEIP-1 function reduced the size of a subset of LDs while over-expression of SEIP-1 had the opposite effect. Ultrastructural analysis revealed SEIP-1 enrichment in an endoplasmic reticulum (ER) subdomain, which co-purified with LDs. Analyses of C. elegans and bacterial genetic mutants indicated a requirement of polyunsaturated fatty acids (PUFAs) and microbial cyclopropane fatty acids (CFAs) for SEIP-1 enrichment, as confirmed by dietary supplementation experiments. In mammalian cells, heterologous expression of SEIP-1 promoted lipid droplet expansion from ER subdomains in a conserved manner. Our results suggest that microbial and polyunsaturated fatty acids serve unexpected roles in regulating cellular fat storage by enforcing LD diversity." @default.
- W2891582920 created "2018-09-27" @default.
- W2891582920 creator A5003347576 @default.
- W2891582920 creator A5011225270 @default.
- W2891582920 creator A5016123511 @default.
- W2891582920 creator A5022573698 @default.
- W2891582920 creator A5025885597 @default.
- W2891582920 creator A5036745704 @default.
- W2891582920 creator A5037995194 @default.
- W2891582920 creator A5050046254 @default.
- W2891582920 creator A5051125527 @default.
- W2891582920 creator A5061989741 @default.
- W2891582920 creator A5081938339 @default.
- W2891582920 creator A5086018302 @default.
- W2891582920 creator A5090905307 @default.
- W2891582920 date "2018-09-22" @default.
- W2891582920 modified "2023-10-14" @default.
- W2891582920 title "Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain" @default.
- W2891582920 cites W1417187450 @default.
- W2891582920 cites W1566497779 @default.
- W2891582920 cites W193190183 @default.
- W2891582920 cites W1938173378 @default.
- W2891582920 cites W1973821281 @default.
- W2891582920 cites W1975794822 @default.
- W2891582920 cites W1977180164 @default.
- W2891582920 cites W1977689678 @default.
- W2891582920 cites W1984160651 @default.
- W2891582920 cites W1984651084 @default.
- W2891582920 cites W1993484144 @default.
- W2891582920 cites W1993813725 @default.
- W2891582920 cites W1997238838 @default.
- W2891582920 cites W2004775480 @default.
- W2891582920 cites W2006061929 @default.
- W2891582920 cites W2008540803 @default.
- W2891582920 cites W2014560331 @default.
- W2891582920 cites W2023949937 @default.
- W2891582920 cites W2027699805 @default.
- W2891582920 cites W2027816974 @default.
- W2891582920 cites W2029318573 @default.
- W2891582920 cites W2036747220 @default.
- W2891582920 cites W2041506421 @default.
- W2891582920 cites W2044073767 @default.
- W2891582920 cites W2045059579 @default.
- W2891582920 cites W2049271632 @default.
- W2891582920 cites W2059790662 @default.
- W2891582920 cites W2061821143 @default.
- W2891582920 cites W2072291193 @default.
- W2891582920 cites W2073162567 @default.
- W2891582920 cites W2073624281 @default.
- W2891582920 cites W2081510628 @default.
- W2891582920 cites W2089303595 @default.
- W2891582920 cites W2096054485 @default.
- W2891582920 cites W2099745966 @default.
- W2891582920 cites W2100253993 @default.
- W2891582920 cites W2101528922 @default.
- W2891582920 cites W2106442657 @default.
- W2891582920 cites W2111967267 @default.
- W2891582920 cites W2120820877 @default.
- W2891582920 cites W2121233961 @default.
- W2891582920 cites W2125355462 @default.
- W2891582920 cites W2125872855 @default.
- W2891582920 cites W2128746061 @default.
- W2891582920 cites W2129646308 @default.
- W2891582920 cites W2132611682 @default.
- W2891582920 cites W2136238917 @default.
- W2891582920 cites W2138956168 @default.
- W2891582920 cites W2150432143 @default.
- W2891582920 cites W2153708911 @default.
- W2891582920 cites W2168734886 @default.
- W2891582920 cites W2169734236 @default.
- W2891582920 cites W2177040066 @default.
- W2891582920 cites W2183967063 @default.
- W2891582920 cites W2186680169 @default.
- W2891582920 cites W2210741571 @default.
- W2891582920 cites W2293412032 @default.
- W2891582920 cites W2465534016 @default.
- W2891582920 cites W2509246155 @default.
- W2891582920 cites W2552567900 @default.
- W2891582920 cites W2560888990 @default.
- W2891582920 cites W2609799650 @default.
- W2891582920 cites W2742994526 @default.
- W2891582920 cites W2767974674 @default.
- W2891582920 cites W2769330816 @default.
- W2891582920 cites W2770632514 @default.
- W2891582920 cites W787314263 @default.
- W2891582920 doi "https://doi.org/10.1101/424663" @default.
- W2891582920 hasPublicationYear "2018" @default.
- W2891582920 type Work @default.
- W2891582920 sameAs 2891582920 @default.
- W2891582920 citedByCount "0" @default.
- W2891582920 crossrefType "posted-content" @default.
- W2891582920 hasAuthorship W2891582920A5003347576 @default.
- W2891582920 hasAuthorship W2891582920A5011225270 @default.
- W2891582920 hasAuthorship W2891582920A5016123511 @default.
- W2891582920 hasAuthorship W2891582920A5022573698 @default.
- W2891582920 hasAuthorship W2891582920A5025885597 @default.
- W2891582920 hasAuthorship W2891582920A5036745704 @default.
- W2891582920 hasAuthorship W2891582920A5037995194 @default.
- W2891582920 hasAuthorship W2891582920A5050046254 @default.
- W2891582920 hasAuthorship W2891582920A5051125527 @default.