FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891586404> ?p ?o ?g. }

• W2891586404 abstract "ABSTRACT Enteric viruses, including poliovirus, are spread by the fecal-oral route. In order to persist and transmit to a new host, enteric virus particles must remain stable once they are in the environment. Environmental stressors such as heat and disinfectants can inactivate virus particles and prevent viral transmission. It has been previously demonstrated that bacteria or bacterial surface glycans can enhance poliovirus virion stability and limit inactivation from heat or bleach. While investigating the mechanisms underlying bacterial-enhanced virion thermal stability, we identified and characterized a poliovirus mutant with increased resistance to heat inactivation. This poliovirus mutant, M132V, harbors a single amino acid change in the VP1 capsid-coding that is sufficient to confer heat resistance. M132V was comparable to wild-type virus for replication in vitro , as well as for replication and pathogenesis in orally-inoculated mice. Although the M132V virus was stable in the absence of bacteria or feces at most temperatures, M132V virus was stabilized by feces at very high temperatures. Additionally, the M132V virus does not have enhanced stability during bleach treatment, suggesting that thermal and bleach inactivation mechanisms are separable. Our results suggest that different mechanisms underlie virion stabilization by bacteria and the M132V mutation. Overall, this work sheds light on factors that influence virion stability. IMPORTANCE Viruses spread by the fecal-oral route need to maintain viability in the environment to ensure transmission. Previous work indicated that bacteria and bacterial surface polysaccharides can stabilize viral particles and enhance transmission. To explore factors that influence viral particle stability, we isolated a mutant poliovirus that is heat resistant. This mutant virus does not require feces for stability at most temperatures, but can be stabilized by feces at very high temperatures. Even though the mutant virus is heat resistant, it is susceptible to inactivation by treatment with bleach. This work provides insight into how viral particles maintain infectivity in the environment." @default.
• W2891586404 created "2018-09-27" @default.
• W2891586404 creator A5058383234 @default.
• W2891586404 creator A5061511885 @default.
• W2891586404 creator A5062111243 @default.
• W2891586404 creator A5072701409 @default.
• W2891586404 date "2018-09-06" @default.
• W2891586404 modified "2023-10-16" @default.
• W2891586404 title "Characterization of a thermal stable poliovirus mutant reveals distinct mechanisms of virion stabilization" @default.
• W2891586404 cites W1544228326 @default.
• W2891586404 cites W1980730655 @default.
• W2891586404 cites W1987125112 @default.
• W2891586404 cites W1997913859 @default.
• W2891586404 cites W2011423580 @default.
• W2891586404 cites W2058530259 @default.
• W2891586404 cites W2060500618 @default.
• W2891586404 cites W2089994382 @default.
• W2891586404 cites W2091791004 @default.
• W2891586404 cites W2101599722 @default.
• W2891586404 cites W2126482736 @default.
• W2891586404 cites W2133646471 @default.
• W2891586404 cites W2146428253 @default.
• W2891586404 cites W2162560584 @default.
• W2891586404 cites W2560169275 @default.
• W2891586404 cites W2776528073 @default.
• W2891586404 cites W2017994881 @default.
• W2891586404 doi "https://doi.org/10.1101/410175" @default.
• W2891586404 hasPublicationYear "2018" @default.
• W2891586404 type Work @default.
• W2891586404 sameAs 2891586404 @default.
• W2891586404 citedByCount "1" @default.
• W2891586404 countsByYear W28915864042018 @default.
• W2891586404 crossrefType "posted-content" @default.
• W2891586404 hasAuthorship W2891586404A5058383234 @default.
• W2891586404 hasAuthorship W2891586404A5061511885 @default.
• W2891586404 hasAuthorship W2891586404A5062111243 @default.
• W2891586404 hasAuthorship W2891586404A5072701409 @default.
• W2891586404 hasBestOaLocation W28915864041 @default.
• W2891586404 hasConcept C104317684 @default.
• W2891586404 hasConcept C140704245 @default.
• W2891586404 hasConcept C143065580 @default.
• W2891586404 hasConcept C159047783 @default.
• W2891586404 hasConcept C182615771 @default.
• W2891586404 hasConcept C2522874641 @default.
• W2891586404 hasConcept C2779631682 @default.
• W2891586404 hasConcept C523546767 @default.
• W2891586404 hasConcept C54355233 @default.
• W2891586404 hasConcept C58123911 @default.
• W2891586404 hasConcept C86803240 @default.
• W2891586404 hasConcept C89423630 @default.
• W2891586404 hasConceptScore W2891586404C104317684 @default.
• W2891586404 hasConceptScore W2891586404C140704245 @default.
• W2891586404 hasConceptScore W2891586404C143065580 @default.
• W2891586404 hasConceptScore W2891586404C159047783 @default.
• W2891586404 hasConceptScore W2891586404C182615771 @default.
• W2891586404 hasConceptScore W2891586404C2522874641 @default.
• W2891586404 hasConceptScore W2891586404C2779631682 @default.
• W2891586404 hasConceptScore W2891586404C523546767 @default.
• W2891586404 hasConceptScore W2891586404C54355233 @default.
• W2891586404 hasConceptScore W2891586404C58123911 @default.
• W2891586404 hasConceptScore W2891586404C86803240 @default.
• W2891586404 hasConceptScore W2891586404C89423630 @default.
• W2891586404 hasLocation W28915864041 @default.
• W2891586404 hasOpenAccess W2891586404 @default.
• W2891586404 hasPrimaryLocation W28915864041 @default.
• W2891586404 hasRelatedWork W2012539582 @default.
• W2891586404 hasRelatedWork W2042841148 @default.
• W2891586404 hasRelatedWork W2065794983 @default.
• W2891586404 hasRelatedWork W2068913867 @default.
• W2891586404 hasRelatedWork W2086778880 @default.
• W2891586404 hasRelatedWork W2132333091 @default.
• W2891586404 hasRelatedWork W2170048370 @default.
• W2891586404 hasRelatedWork W2185001721 @default.
• W2891586404 hasRelatedWork W2377185924 @default.
• W2891586404 hasRelatedWork W69381317 @default.
• W2891586404 isParatext "false" @default.
• W2891586404 isRetracted "false" @default.
• W2891586404 magId "2891586404" @default.
• W2891586404 workType "article" @default.