FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891590181> ?p ?o ?g. }

• W2891590181 endingPage "156" @default.
• W2891590181 startingPage "147" @default.
• W2891590181 abstract "Obesity is associated with comorbidities such as diabetes and hepatic steatosis. β-Glucans have been described as effective in treating conditions including dyslipidaemia and diabetes. Thus, the objective of this study was to evaluate the effects of botryosphaeran [(1 → 3)(1 → 6)-β-D-glucan] on obesity and its comorbidities, and understand its mechanism of action.Obesity was induced in adult male Wistar rats by ingestion of a high-fat diet and water with sucrose (300 g/L) for 8 weeks. Control rats received standard diet. After six weeks, treatment commenced with botryosphaeran (12 mg/kg.b.w., via gavage, 15 days), respective controls received water. Rats were divided into 3 groups: control (C), obese (O), and obese + botryosphaeran (OB). In the 8th week, obesity was characterized. Feed-intake, glucose and lipid profiles, glucose tolerance, and concentrations of glycogen and lipids in liver were analyzed. Protein expression was determined by Western blotting.Obese rats showed significant increases in weight gain and adipose tissue, presented glucose intolerance, dyslipidaemia, and hepatic steatosis. Botryosphaeran significantly reduced feed intake, weight gain, periepididymal and mesenteric fat, and improved glucose tolerance. Botryosphaeran also reduced triglyceride and VLDL, and increased HDL levels. Furthermore, botryosphaeran increased glycogen and reduced total lipids, triglycerides and cholesterol in liver, and increased AMP-activated protein kinase(AMPK) activity and Forkhead transcription factor 3a(FOXO3a) protein expression in adipose tissue.This study demonstrated that botryosphaeran was effective in reducing obesity, hepatic steatosis, dyslipidaemia insulin resistance and glucose intolerance in diet-induced obese rats, and these effects were, at least in part, associated with reduced feed intake, and AMPK and FOXO3a activities." @default.
• W2891590181 created "2018-09-27" @default.
• W2891590181 creator A5016687071 @default.
• W2891590181 creator A5025190123 @default.
• W2891590181 creator A5030638898 @default.
• W2891590181 creator A5033253870 @default.
• W2891590181 creator A5056111072 @default.
• W2891590181 creator A5057698493 @default.
• W2891590181 creator A5071935880 @default.
• W2891590181 creator A5076564554 @default.
• W2891590181 creator A5077887871 @default.
• W2891590181 creator A5078532753 @default.
• W2891590181 creator A5088325194 @default.
• W2891590181 creator A5088487664 @default.
• W2891590181 creator A5091047109 @default.
• W2891590181 date "2018-10-01" @default.
• W2891590181 modified "2023-10-15" @default.
• W2891590181 title "Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats" @default.
• W2891590181 cites W145408741 @default.
• W2891590181 cites W1719416134 @default.
• W2891590181 cites W1852016922 @default.
• W2891590181 cites W1927710737 @default.
• W2891590181 cites W1967999753 @default.
• W2891590181 cites W1970205234 @default.
• W2891590181 cites W1973622869 @default.
• W2891590181 cites W1978281808 @default.
• W2891590181 cites W1978599577 @default.
• W2891590181 cites W1981770848 @default.
• W2891590181 cites W1986896225 @default.
• W2891590181 cites W1988109900 @default.
• W2891590181 cites W1999675324 @default.
• W2891590181 cites W2001749311 @default.
• W2891590181 cites W2002611996 @default.
• W2891590181 cites W2010124851 @default.
• W2891590181 cites W2013448617 @default.
• W2891590181 cites W2014000186 @default.
• W2891590181 cites W2014887370 @default.
• W2891590181 cites W2019194227 @default.
• W2891590181 cites W2027850869 @default.
• W2891590181 cites W2035576567 @default.
• W2891590181 cites W2041368867 @default.
• W2891590181 cites W2049136865 @default.
• W2891590181 cites W2053353938 @default.
• W2891590181 cites W2072020618 @default.
• W2891590181 cites W2086487313 @default.
• W2891590181 cites W2091320813 @default.
• W2891590181 cites W2092183716 @default.
• W2891590181 cites W2093608891 @default.
• W2891590181 cites W2103450921 @default.
• W2891590181 cites W2116404316 @default.
• W2891590181 cites W2118029488 @default.
• W2891590181 cites W2119754462 @default.
• W2891590181 cites W2123429601 @default.
• W2891590181 cites W2123675377 @default.
• W2891590181 cites W2132039553 @default.
• W2891590181 cites W2143061685 @default.
• W2891590181 cites W2143834135 @default.
• W2891590181 cites W2150898264 @default.
• W2891590181 cites W2155243001 @default.
• W2891590181 cites W2160965878 @default.
• W2891590181 cites W2163144009 @default.
• W2891590181 cites W2166427023 @default.
• W2891590181 cites W2166935938 @default.
• W2891590181 cites W2167210681 @default.
• W2891590181 cites W2167970026 @default.
• W2891590181 cites W2168526937 @default.
• W2891590181 cites W2171228322 @default.
• W2891590181 cites W2467621422 @default.
• W2891590181 cites W2566222830 @default.
• W2891590181 cites W2568976536 @default.
• W2891590181 cites W2625887862 @default.
• W2891590181 cites W2780752343 @default.
• W2891590181 doi "https://doi.org/10.1016/j.lfs.2018.09.027" @default.
• W2891590181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227131" @default.
• W2891590181 hasPublicationYear "2018" @default.
• W2891590181 type Work @default.
• W2891590181 sameAs 2891590181 @default.
• W2891590181 citedByCount "17" @default.
• W2891590181 countsByYear W28915901812019 @default.
• W2891590181 countsByYear W28915901812020 @default.
• W2891590181 countsByYear W28915901812021 @default.
• W2891590181 countsByYear W28915901812022 @default.
• W2891590181 countsByYear W28915901812023 @default.
• W2891590181 crossrefType "journal-article" @default.
• W2891590181 hasAuthorship W2891590181A5016687071 @default.
• W2891590181 hasAuthorship W2891590181A5025190123 @default.
• W2891590181 hasAuthorship W2891590181A5030638898 @default.
• W2891590181 hasAuthorship W2891590181A5033253870 @default.
• W2891590181 hasAuthorship W2891590181A5056111072 @default.
• W2891590181 hasAuthorship W2891590181A5057698493 @default.
• W2891590181 hasAuthorship W2891590181A5071935880 @default.
• W2891590181 hasAuthorship W2891590181A5076564554 @default.
• W2891590181 hasAuthorship W2891590181A5077887871 @default.
• W2891590181 hasAuthorship W2891590181A5078532753 @default.
• W2891590181 hasAuthorship W2891590181A5088325194 @default.
• W2891590181 hasAuthorship W2891590181A5088487664 @default.
• W2891590181 hasAuthorship W2891590181A5091047109 @default.
• W2891590181 hasConcept C126322002 @default.

• next