FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891590428> ?p ?o ?g. }

• W2891590428 endingPage "518" @default.
• W2891590428 startingPage "508" @default.
• W2891590428 abstract "Abstract High mobility group A2 (HMGA2) is an architectural transcription factor that promotes human colorectal cancer (CRC) aggressiveness by modulating the transcription of target genes. The degradation of p53 is mediated by murine double minute 2 (MDM2) in a proteasome‐dependent manner. Here we report that HMGA2 promotes cell cycle progression and inhibits apoptosis in CRC cells in vitro . We also developed an intestinal epithelial cell‐specific Hmga2 knock‐in (KI) mouse model. It revealed that the Hmga2 KI promoted chemical carcinogen‐induced tumorigenesis in the intestine in vivo . In studying the underlying molecular mechanism, we found that HMGA2 formed a protein complex with p53. The tetramerization domain of p53 (amino acids 294–393) and the three AT‐hook domains (amino acids 1–83) of HMGA2 were responsible for their direct interaction. We also found that HMGA2 directly bound to MDM2 and the central acidic and zinc finger domains of MDM2 (amino acids 111–360) were required for interaction with HMGA2. Furthermore, our results indicated that HMGA2 promoted MDM2‐mediated p53 ubiquitination and degradation. Interestingly, Hmga2 overexpression in Hmga2 KI mice resulted in an increase in the accumulation of ubiquitinated p53. In addition, in two large CRC cohorts, it was demonstrated that high HMGA2 expression was predictive of an adverse outcome in the p53‐negative subgroup of CRC patients. In summary, our data have established for the first time a novel mechanism by which HMGA2 functions with p53 and MDM2 to promote CRC progression. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
• W2891590428 created "2018-09-27" @default.
• W2891590428 creator A5032764121 @default.
• W2891590428 creator A5040198181 @default.
• W2891590428 creator A5049542583 @default.
• W2891590428 creator A5072036342 @default.
• W2891590428 creator A5082695020 @default.
• W2891590428 creator A5083509091 @default.
• W2891590428 creator A5083911874 @default.
• W2891590428 date "2018-11-16" @default.
• W2891590428 modified "2023-10-12" @default.
• W2891590428 title "HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53" @default.
• W2891590428 cites W1495624224 @default.
• W2891590428 cites W1495672122 @default.
• W2891590428 cites W1963872465 @default.
• W2891590428 cites W1964719993 @default.
• W2891590428 cites W1965581435 @default.
• W2891590428 cites W1966841369 @default.
• W2891590428 cites W1968075505 @default.
• W2891590428 cites W1976295398 @default.
• W2891590428 cites W1976631815 @default.
• W2891590428 cites W1976633722 @default.
• W2891590428 cites W1998577031 @default.
• W2891590428 cites W1999918093 @default.
• W2891590428 cites W2012315992 @default.
• W2891590428 cites W2025035284 @default.
• W2891590428 cites W2025722611 @default.
• W2891590428 cites W2029343580 @default.
• W2891590428 cites W2032474685 @default.
• W2891590428 cites W2043329242 @default.
• W2891590428 cites W2062662373 @default.
• W2891590428 cites W2079076511 @default.
• W2891590428 cites W2093619351 @default.
• W2891590428 cites W2104245789 @default.
• W2891590428 cites W2107739085 @default.
• W2891590428 cites W2113405864 @default.
• W2891590428 cites W2167758528 @default.
• W2891590428 cites W2168933846 @default.
• W2891590428 cites W2178157469 @default.
• W2891590428 cites W2188698563 @default.
• W2891590428 cites W2196835862 @default.
• W2891590428 cites W2204583106 @default.
• W2891590428 cites W2260004169 @default.
• W2891590428 cites W2261110864 @default.
• W2891590428 cites W2261520634 @default.
• W2891590428 cites W2303171964 @default.
• W2891590428 cites W2317379862 @default.
• W2891590428 cites W2319281231 @default.
• W2891590428 cites W2535234247 @default.
• W2891590428 cites W2553730830 @default.
• W2891590428 cites W2580740170 @default.
• W2891590428 cites W2596553151 @default.
• W2891590428 cites W2616864589 @default.
• W2891590428 cites W2721940575 @default.
• W2891590428 cites W2725665043 @default.
• W2891590428 cites W2740574829 @default.
• W2891590428 cites W2742373277 @default.
• W2891590428 cites W2772062014 @default.
• W2891590428 cites W4211199921 @default.
• W2891590428 doi "https://doi.org/10.1002/path.5164" @default.
• W2891590428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175854" @default.
• W2891590428 hasPublicationYear "2018" @default.
• W2891590428 type Work @default.
• W2891590428 sameAs 2891590428 @default.
• W2891590428 citedByCount "19" @default.
• W2891590428 countsByYear W28915904282019 @default.
• W2891590428 countsByYear W28915904282020 @default.
• W2891590428 countsByYear W28915904282021 @default.
• W2891590428 countsByYear W28915904282022 @default.
• W2891590428 countsByYear W28915904282023 @default.
• W2891590428 crossrefType "journal-article" @default.
• W2891590428 hasAuthorship W2891590428A5032764121 @default.
• W2891590428 hasAuthorship W2891590428A5040198181 @default.
• W2891590428 hasAuthorship W2891590428A5049542583 @default.
• W2891590428 hasAuthorship W2891590428A5072036342 @default.
• W2891590428 hasAuthorship W2891590428A5082695020 @default.
• W2891590428 hasAuthorship W2891590428A5083509091 @default.
• W2891590428 hasAuthorship W2891590428A5083911874 @default.
• W2891590428 hasConcept C104317684 @default.
• W2891590428 hasConcept C114246631 @default.
• W2891590428 hasConcept C121608353 @default.
• W2891590428 hasConcept C145059251 @default.
• W2891590428 hasConcept C185592680 @default.
• W2891590428 hasConcept C190283241 @default.
• W2891590428 hasConcept C2529059 @default.
• W2891590428 hasConcept C25602115 @default.
• W2891590428 hasConcept C2776192174 @default.
• W2891590428 hasConcept C502942594 @default.
• W2891590428 hasConcept C54355233 @default.
• W2891590428 hasConcept C55493867 @default.
• W2891590428 hasConcept C555283112 @default.
• W2891590428 hasConcept C86339819 @default.
• W2891590428 hasConcept C86803240 @default.
• W2891590428 hasConcept C95444343 @default.
• W2891590428 hasConceptScore W2891590428C104317684 @default.
• W2891590428 hasConceptScore W2891590428C114246631 @default.
• W2891590428 hasConceptScore W2891590428C121608353 @default.
• W2891590428 hasConceptScore W2891590428C145059251 @default.

• next