Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891590730> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2891590730 abstract "Klebsiella pneumoniae is a Gram negative facultative anaerobic bacterium commonly found in environmental reservoirs and is capable of colonizing human niches. In neonates, the elderly, and generally immunodeficient persons, K. pneumoniae is capable of causing invasive disease. This is of clinical significance due to the general distress caused by a variety of procedures in the healthcare setting that can increase the risk of infection. As a direct result, K. pneumoniae is the cause of approximately 12,000 healthcare-associated infections every year in the United States. The anesthetic propofol is frequently utilized in the clinic for sedation and previous work in the Freitag lab has demonstrated that brief sedation with propofol is sufficient to dysregulate immune responses to bacterial bloodstream infections, leading to more severe pathology and impaired resolution. Herein, we investigated whether propofol sedation would lead to altered immune responses in a K. pneumoniae lung infection model. Propofol was found to increase lung burdens at early time points compared to controls, while simultaneously increasing immune cell recruitment to the lungs, suggesting that these responding populations were functionally deficient. Furthermore, propofol sedation also led to increased lung tissue destruction with K. pneumoniae establishing large replicative niches. Gene expression analysis in the lung revealed that propofol was precipitating a hyper-inflammatory response in the lung that preceded a systemic inflammatory response comparable to clinical sepsis. In light of these findings, we investigated whether propofol sedation would have any impact on Klebsiella virulence factor requirements in the lung using high-throughput insertion sequencing. We identified multiple gene products that were differentially required for successful lung outgrowth depending on the sedative used during infection, demonstrating that propofol sedation affects both the host immune response and Klebsiella’s required virulence repertoire during lung infection." @default.
- W2891590730 created "2018-09-27" @default.
- W2891590730 creator A5017724621 @default.
- W2891590730 date "2017-12-01" @default.
- W2891590730 modified "2023-09-27" @default.
- W2891590730 title "The Impact Of Propofol On Klebsiella Lung Infection" @default.
- W2891590730 hasPublicationYear "2017" @default.
- W2891590730 type Work @default.
- W2891590730 sameAs 2891590730 @default.
- W2891590730 citedByCount "0" @default.
- W2891590730 crossrefType "dissertation" @default.
- W2891590730 hasAuthorship W2891590730A5017724621 @default.
- W2891590730 hasConcept C104317684 @default.
- W2891590730 hasConcept C126322002 @default.
- W2891590730 hasConcept C203014093 @default.
- W2891590730 hasConcept C2775953899 @default.
- W2891590730 hasConcept C2776277131 @default.
- W2891590730 hasConcept C2776814716 @default.
- W2891590730 hasConcept C2777058267 @default.
- W2891590730 hasConcept C2777714996 @default.
- W2891590730 hasConcept C2778384902 @default.
- W2891590730 hasConcept C42219234 @default.
- W2891590730 hasConcept C547475151 @default.
- W2891590730 hasConcept C55493867 @default.
- W2891590730 hasConcept C71924100 @default.
- W2891590730 hasConcept C86803240 @default.
- W2891590730 hasConcept C8891405 @default.
- W2891590730 hasConceptScore W2891590730C104317684 @default.
- W2891590730 hasConceptScore W2891590730C126322002 @default.
- W2891590730 hasConceptScore W2891590730C203014093 @default.
- W2891590730 hasConceptScore W2891590730C2775953899 @default.
- W2891590730 hasConceptScore W2891590730C2776277131 @default.
- W2891590730 hasConceptScore W2891590730C2776814716 @default.
- W2891590730 hasConceptScore W2891590730C2777058267 @default.
- W2891590730 hasConceptScore W2891590730C2777714996 @default.
- W2891590730 hasConceptScore W2891590730C2778384902 @default.
- W2891590730 hasConceptScore W2891590730C42219234 @default.
- W2891590730 hasConceptScore W2891590730C547475151 @default.
- W2891590730 hasConceptScore W2891590730C55493867 @default.
- W2891590730 hasConceptScore W2891590730C71924100 @default.
- W2891590730 hasConceptScore W2891590730C86803240 @default.
- W2891590730 hasConceptScore W2891590730C8891405 @default.
- W2891590730 hasLocation W28915907301 @default.
- W2891590730 hasOpenAccess W2891590730 @default.
- W2891590730 hasPrimaryLocation W28915907301 @default.
- W2891590730 hasRelatedWork W1888726479 @default.
- W2891590730 hasRelatedWork W2078825368 @default.
- W2891590730 hasRelatedWork W2104547218 @default.
- W2891590730 hasRelatedWork W2142176077 @default.
- W2891590730 hasRelatedWork W2147784343 @default.
- W2891590730 hasRelatedWork W2167467683 @default.
- W2891590730 hasRelatedWork W2201819417 @default.
- W2891590730 hasRelatedWork W2330606664 @default.
- W2891590730 hasRelatedWork W2372481770 @default.
- W2891590730 hasRelatedWork W2395328173 @default.
- W2891590730 hasRelatedWork W2412048479 @default.
- W2891590730 hasRelatedWork W2418692341 @default.
- W2891590730 hasRelatedWork W2476654775 @default.
- W2891590730 hasRelatedWork W2610902909 @default.
- W2891590730 hasRelatedWork W2799816271 @default.
- W2891590730 hasRelatedWork W2917636544 @default.
- W2891590730 hasRelatedWork W2955047238 @default.
- W2891590730 hasRelatedWork W2963781036 @default.
- W2891590730 hasRelatedWork W3189968138 @default.
- W2891590730 hasRelatedWork W2989291367 @default.
- W2891590730 isParatext "false" @default.
- W2891590730 isRetracted "false" @default.
- W2891590730 magId "2891590730" @default.
- W2891590730 workType "dissertation" @default.