Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891602481> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2891602481 abstract "Long-range intracellular transport is facilitated by motor proteins like kinesin-1 and cyto-plasmic dynein walking along microtubules (MTs). These motors often work in teams for the transport of various intracellular cargos. While transport by multiple kinesin-1 motors has been studied extensively in the past, collective effects of cytoplasmic dynein are less well understood. On the level of single molecules, mammalian cytoplasmic dynein is not active in the absence of dynactin and adaptor proteins. However, when assembled into a team bound to the same cargo, processive motility has been observed. The underlying mechanism of this activation is not known. Here, we found that in MT gliding motility assays the gliding velocity increased with dynein surface density and MT length. Developing a mathematical model based on single-molecule parameters, we were able to simulate the observed behavior. Integral to our model is the usage of an activation term, which describes a mechanical activation of individual dynein motors when being stretched by the other motors. We hypothesize this activation to be similar to the activation of single dynein motors by dynactin and adaptor proteins." @default.
- W2891602481 created "2018-09-27" @default.
- W2891602481 creator A5002043565 @default.
- W2891602481 creator A5022921629 @default.
- W2891602481 creator A5024888062 @default.
- W2891602481 creator A5046714838 @default.
- W2891602481 date "2018-01-01" @default.
- W2891602481 modified "2023-09-27" @default.
- W2891602481 title "Activation of mammalian cytoplasmic dynein in multi-motor motility assays" @default.
- W2891602481 cites W1580373331 @default.
- W2891602481 cites W1593716142 @default.
- W2891602481 cites W1963489221 @default.
- W2891602481 cites W1974454876 @default.
- W2891602481 cites W1977196587 @default.
- W2891602481 cites W1978647740 @default.
- W2891602481 cites W1988784173 @default.
- W2891602481 cites W1992045863 @default.
- W2891602481 cites W1995095100 @default.
- W2891602481 cites W2002444209 @default.
- W2891602481 cites W2007502298 @default.
- W2891602481 cites W2020007964 @default.
- W2891602481 cites W2025971795 @default.
- W2891602481 cites W2031194197 @default.
- W2891602481 cites W2057096287 @default.
- W2891602481 cites W2063976954 @default.
- W2891602481 cites W2099485650 @default.
- W2891602481 cites W2132655928 @default.
- W2891602481 cites W2135069767 @default.
- W2891602481 cites W2140815397 @default.
- W2891602481 cites W2154235253 @default.
- W2891602481 cites W2155418451 @default.
- W2891602481 cites W2161369215 @default.
- W2891602481 cites W2161951202 @default.
- W2891602481 cites W2170991710 @default.
- W2891602481 cites W2479788400 @default.
- W2891602481 cites W2607056421 @default.
- W2891602481 cites W2623370846 @default.
- W2891602481 doi "https://doi.org/10.1242/jcs.220079" @default.
- W2891602481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30237223" @default.
- W2891602481 hasPublicationYear "2018" @default.
- W2891602481 type Work @default.
- W2891602481 sameAs 2891602481 @default.
- W2891602481 citedByCount "8" @default.
- W2891602481 countsByYear W28916024812018 @default.
- W2891602481 countsByYear W28916024812020 @default.
- W2891602481 countsByYear W28916024812021 @default.
- W2891602481 crossrefType "journal-article" @default.
- W2891602481 hasAuthorship W2891602481A5002043565 @default.
- W2891602481 hasAuthorship W2891602481A5022921629 @default.
- W2891602481 hasAuthorship W2891602481A5024888062 @default.
- W2891602481 hasAuthorship W2891602481A5046714838 @default.
- W2891602481 hasBestOaLocation W28916024811 @default.
- W2891602481 hasConcept C106987784 @default.
- W2891602481 hasConcept C12554922 @default.
- W2891602481 hasConcept C134729014 @default.
- W2891602481 hasConcept C160408235 @default.
- W2891602481 hasConcept C183786373 @default.
- W2891602481 hasConcept C190062978 @default.
- W2891602481 hasConcept C20418707 @default.
- W2891602481 hasConcept C58207958 @default.
- W2891602481 hasConcept C59006786 @default.
- W2891602481 hasConcept C62478195 @default.
- W2891602481 hasConcept C86803240 @default.
- W2891602481 hasConcept C93126451 @default.
- W2891602481 hasConcept C95444343 @default.
- W2891602481 hasConceptScore W2891602481C106987784 @default.
- W2891602481 hasConceptScore W2891602481C12554922 @default.
- W2891602481 hasConceptScore W2891602481C134729014 @default.
- W2891602481 hasConceptScore W2891602481C160408235 @default.
- W2891602481 hasConceptScore W2891602481C183786373 @default.
- W2891602481 hasConceptScore W2891602481C190062978 @default.
- W2891602481 hasConceptScore W2891602481C20418707 @default.
- W2891602481 hasConceptScore W2891602481C58207958 @default.
- W2891602481 hasConceptScore W2891602481C59006786 @default.
- W2891602481 hasConceptScore W2891602481C62478195 @default.
- W2891602481 hasConceptScore W2891602481C86803240 @default.
- W2891602481 hasConceptScore W2891602481C93126451 @default.
- W2891602481 hasConceptScore W2891602481C95444343 @default.
- W2891602481 hasLocation W28916024811 @default.
- W2891602481 hasLocation W28916024812 @default.
- W2891602481 hasOpenAccess W2891602481 @default.
- W2891602481 hasPrimaryLocation W28916024811 @default.
- W2891602481 hasRelatedWork W1449815498 @default.
- W2891602481 hasRelatedWork W1974528900 @default.
- W2891602481 hasRelatedWork W2020023254 @default.
- W2891602481 hasRelatedWork W2610418440 @default.
- W2891602481 hasRelatedWork W269253930 @default.
- W2891602481 hasRelatedWork W2891602481 @default.
- W2891602481 hasRelatedWork W4225596762 @default.
- W2891602481 hasRelatedWork W4226170906 @default.
- W2891602481 hasRelatedWork W4233075011 @default.
- W2891602481 hasRelatedWork W4253087008 @default.
- W2891602481 isParatext "false" @default.
- W2891602481 isRetracted "false" @default.
- W2891602481 magId "2891602481" @default.
- W2891602481 workType "article" @default.