FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891605529> ?p ?o ?g. }

• W2891605529 endingPage "389" @default.
• W2891605529 startingPage "379" @default.
• W2891605529 abstract "Abstract Context Safety concerns have been raised regarding premature mortality, diabetes, neoplasia, and cerebrovascular disease in association with GH therapy. Objective To assess incidence of key safety outcomes. Design Prospective, multinational, observational study (1999 to 2015). Setting A total of 22,311 GH-treated children from 827 investigative sites in 30 countries. Patients Children with growth disorders. Interventions GH treatment. Main outcome measures Standardized mortality ratio (SMR) and standardized incidence ratio (SIR) with 95% CIs for mortality, diabetes, and primary cancer using general population registries. Results Predominant short stature diagnoses were GH deficiency (63%), idiopathic short stature (13%), and Turner syndrome (8%), with mean ± SD follow-up of 4.2 ± 3.2 years (∼92,000 person-years [PY]). Forty-two deaths occurred in patients with follow-up, with an SMR (95% CI) of 0.61 (0.44, 0.82); the SMR was elevated for patients with cancer-related organic GH deficiency [5.87 (3.21, 9.85)]. Based on 18 cases, type 2 diabetes mellitus (T2DM) risk was elevated [SIR: 3.77 (2.24, 5.96)], but 72% had risk factors. In patients without cancer history, 14 primary cancers were observed [SIR: 0.71 (0.39, 1.20)]. Second neoplasms occurred in 31 of 622 cancer survivors [5.0%; 10.7 (7.5, 15.2) cases/1000 PY] and intracranial tumor recurrences in 67 of 823 tumor survivors [8.1%; 16.9 (13.3, 21.5) cases/1000 PY]. All three hemorrhagic stroke cases had risk factors. Conclusions GeNeSIS (Genetics and Neuroendocrinology of Short Stature International Study) data support the favorable safety profile of pediatric GH treatment. Overall risk of death or primary cancer was not elevated in GH-treated children, and no hemorrhagic strokes occurred in patients without risk factors. T2DM incidence was elevated compared with the general population, but most cases had diabetes risk factors." @default.
• W2891605529 created "2018-09-27" @default.
• W2891605529 creator A5001402556 @default.
• W2891605529 creator A5001456290 @default.
• W2891605529 creator A5004821591 @default.
• W2891605529 creator A5009389023 @default.
• W2891605529 creator A5010979187 @default.
• W2891605529 creator A5014785518 @default.
• W2891605529 creator A5016135368 @default.
• W2891605529 creator A5021144211 @default.
• W2891605529 creator A5024254920 @default.
• W2891605529 creator A5045854494 @default.
• W2891605529 creator A5046164327 @default.
• W2891605529 creator A5049322494 @default.
• W2891605529 creator A5051103665 @default.
• W2891605529 creator A5054756377 @default.
• W2891605529 creator A5059324157 @default.
• W2891605529 creator A5072374712 @default.
• W2891605529 creator A5072496924 @default.
• W2891605529 creator A5073167389 @default.
• W2891605529 creator A5077054564 @default.
• W2891605529 date "2018-09-13" @default.
• W2891605529 modified "2023-10-13" @default.
• W2891605529 title "Safety Outcomes During Pediatric GH Therapy: Final Results From the Prospective GeNeSIS Observational Program" @default.
• W2891605529 cites W1965846492 @default.
• W2891605529 cites W1999827653 @default.
• W2891605529 cites W2009966900 @default.
• W2891605529 cites W2060875814 @default.
• W2891605529 cites W2067376123 @default.
• W2891605529 cites W2068181659 @default.
• W2891605529 cites W2070777958 @default.
• W2891605529 cites W2073012461 @default.
• W2891605529 cites W2075300448 @default.
• W2891605529 cites W2086789132 @default.
• W2891605529 cites W2095141168 @default.
• W2891605529 cites W2096122032 @default.
• W2891605529 cites W2096933977 @default.
• W2891605529 cites W2099860673 @default.
• W2891605529 cites W2108934319 @default.
• W2891605529 cites W2109335006 @default.
• W2891605529 cites W2113022073 @default.
• W2891605529 cites W2113796718 @default.
• W2891605529 cites W2128134961 @default.
• W2891605529 cites W2146254139 @default.
• W2891605529 cites W2150210382 @default.
• W2891605529 cites W2160159332 @default.
• W2891605529 cites W2163954745 @default.
• W2891605529 cites W2164396925 @default.
• W2891605529 cites W2190367334 @default.
• W2891605529 cites W2196962339 @default.
• W2891605529 cites W2276256138 @default.
• W2891605529 cites W2285896502 @default.
• W2891605529 cites W2357948387 @default.
• W2891605529 cites W2515433271 @default.
• W2891605529 cites W2592087460 @default.
• W2891605529 cites W2597357044 @default.
• W2891605529 cites W2604299919 @default.
• W2891605529 cites W2618242417 @default.
• W2891605529 cites W2724744060 @default.
• W2891605529 cites W2765522237 @default.
• W2891605529 cites W4213156113 @default.
• W2891605529 cites W952220580 @default.
• W2891605529 doi "https://doi.org/10.1210/jc.2018-01189" @default.
• W2891605529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6300411" @default.
• W2891605529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30219920" @default.
• W2891605529 hasPublicationYear "2018" @default.
• W2891605529 type Work @default.
• W2891605529 sameAs 2891605529 @default.
• W2891605529 citedByCount "46" @default.
• W2891605529 countsByYear W28916055292019 @default.
• W2891605529 countsByYear W28916055292020 @default.
• W2891605529 countsByYear W28916055292021 @default.
• W2891605529 countsByYear W28916055292022 @default.
• W2891605529 countsByYear W28916055292023 @default.
• W2891605529 crossrefType "journal-article" @default.
• W2891605529 hasAuthorship W2891605529A5001402556 @default.
• W2891605529 hasAuthorship W2891605529A5001456290 @default.
• W2891605529 hasAuthorship W2891605529A5004821591 @default.
• W2891605529 hasAuthorship W2891605529A5009389023 @default.
• W2891605529 hasAuthorship W2891605529A5010979187 @default.
• W2891605529 hasAuthorship W2891605529A5014785518 @default.
• W2891605529 hasAuthorship W2891605529A5016135368 @default.
• W2891605529 hasAuthorship W2891605529A5021144211 @default.
• W2891605529 hasAuthorship W2891605529A5024254920 @default.
• W2891605529 hasAuthorship W2891605529A5045854494 @default.
• W2891605529 hasAuthorship W2891605529A5046164327 @default.
• W2891605529 hasAuthorship W2891605529A5049322494 @default.
• W2891605529 hasAuthorship W2891605529A5051103665 @default.
• W2891605529 hasAuthorship W2891605529A5054756377 @default.
• W2891605529 hasAuthorship W2891605529A5059324157 @default.
• W2891605529 hasAuthorship W2891605529A5072374712 @default.
• W2891605529 hasAuthorship W2891605529A5072496924 @default.
• W2891605529 hasAuthorship W2891605529A5073167389 @default.
• W2891605529 hasAuthorship W2891605529A5077054564 @default.
• W2891605529 hasBestOaLocation W28916055291 @default.
• W2891605529 hasConcept C120665830 @default.
• W2891605529 hasConcept C121332964 @default.
• W2891605529 hasConcept C121608353 @default.

• next