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- W2891607360 endingPage "R14" @default.
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- W2891607360 abstract "The ubiquitin system regulates diverse biological processes, many involved in cancer pathogenesis, by altering the ubiquitination state of protein substrates. This is accomplished by ubiquitin ligases and deubiquitinases (DUBs), which respectively add or remove ubiquitin from substrates to alter their stability, activity, localization and interactions. While lack of catalytic activity makes therapeutic targeting of ubiquitin ligases difficult, DUB inhibitors represent an active area of research and the identification of cancer-associated DUBs may lead to the development of novel therapeutics. A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer-associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance. In addition, clinical studies have associated elevated OTUB1 expression with high grade, invasiveness and metastasis in several tumor types including lung, breast, ovarian, glioma, colon and gastric. Interestingly, in addition to catalytic DUB activity, OTUB1 displays a catalytic-independent, non-canonical activity where it inhibits the transfer of ubiquitin onto protein substrates by sequestration of E2 ubiquitin-conjugating enzymes. The aim of this review is to describe the canonical and non-canonical activities of OTUB1, summarize roles for OTUB1 in cancer-associated pathways and discuss its potential therapeutic targeting." @default.
- W2891607360 created "2018-09-27" @default.
- W2891607360 creator A5011088481 @default.
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- W2891607360 creator A5017121597 @default.
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- W2891607360 date "2019-01-01" @default.
- W2891607360 modified "2023-10-17" @default.
- W2891607360 title "Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer" @default.
- W2891607360 cites W1564987250 @default.
- W2891607360 cites W1576330810 @default.
- W2891607360 cites W1576842236 @default.
- W2891607360 cites W1603781996 @default.
- W2891607360 cites W1930964488 @default.
- W2891607360 cites W1970826261 @default.
- W2891607360 cites W1972872255 @default.
- W2891607360 cites W1974389826 @default.
- W2891607360 cites W1974499183 @default.
- W2891607360 cites W1978859439 @default.
- W2891607360 cites W1981206208 @default.
- W2891607360 cites W1982968963 @default.
- W2891607360 cites W1999290683 @default.
- W2891607360 cites W2001499126 @default.
- W2891607360 cites W2003971548 @default.
- W2891607360 cites W2021565943 @default.
- W2891607360 cites W2022553982 @default.
- W2891607360 cites W2030800389 @default.
- W2891607360 cites W2034346780 @default.
- W2891607360 cites W2035185970 @default.
- W2891607360 cites W2037407781 @default.
- W2891607360 cites W2041755933 @default.
- W2891607360 cites W2045979076 @default.
- W2891607360 cites W2047823765 @default.
- W2891607360 cites W2048004132 @default.
- W2891607360 cites W2055811314 @default.
- W2891607360 cites W2056753605 @default.
- W2891607360 cites W2058098723 @default.
- W2891607360 cites W2062137294 @default.
- W2891607360 cites W2062410054 @default.
- W2891607360 cites W2072310367 @default.
- W2891607360 cites W2072403982 @default.
- W2891607360 cites W2075939050 @default.
- W2891607360 cites W2086711528 @default.
- W2891607360 cites W2094850025 @default.
- W2891607360 cites W2095424116 @default.
- W2891607360 cites W2101547995 @default.
- W2891607360 cites W2106969933 @default.
- W2891607360 cites W2108237056 @default.
- W2891607360 cites W2109095539 @default.
- W2891607360 cites W2121548063 @default.
- W2891607360 cites W2122481965 @default.
- W2891607360 cites W2128551987 @default.
- W2891607360 cites W2133819225 @default.
- W2891607360 cites W2135700703 @default.
- W2891607360 cites W2135737620 @default.
- W2891607360 cites W2136280424 @default.
- W2891607360 cites W2139592339 @default.
- W2891607360 cites W2146153138 @default.
- W2891607360 cites W2147917253 @default.
- W2891607360 cites W2158359547 @default.
- W2891607360 cites W2166219550 @default.
- W2891607360 cites W2166898507 @default.
- W2891607360 cites W2167898988 @default.
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- W2891607360 cites W2232997241 @default.
- W2891607360 cites W2267814167 @default.
- W2891607360 cites W2281556458 @default.
- W2891607360 cites W2316934441 @default.
- W2891607360 cites W2346071290 @default.
- W2891607360 cites W2413794983 @default.
- W2891607360 cites W2565996772 @default.
- W2891607360 cites W2583716494 @default.
- W2891607360 cites W2587517604 @default.
- W2891607360 cites W2589333368 @default.
- W2891607360 cites W2620663439 @default.
- W2891607360 cites W2753679636 @default.
- W2891607360 cites W2769073238 @default.
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- W2891607360 doi "https://doi.org/10.1530/erc-18-0264" @default.
- W2891607360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6226034" @default.
- W2891607360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30400005" @default.
- W2891607360 hasPublicationYear "2019" @default.
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