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• W2891610221 abstract "Coenzyme F 420 -dependent reactions of Mycobacterium tuberculosis , which causes tuberculosis, potentially contributes to the virulence of this bacterium. The coenzyme carries a glutamic acid-derived tail, the length of which influences the metabolism of M. tuberculosis . Mutations that eliminate the production of F 420 with longer tails make M. tuberculosis resistant to two new tuberculosis drugs. This report describes that the synthesis of longer glutamyl tails of F 420 requires concerted actions of two enzymes, one of which reduces the coenzyme prior to the action of the other, which catalyzes polyglutamylation. This knowledge will help to develop more effective tuberculosis (TB) drugs. Remarkably, the introduction of multiple glutamate residues into the sidechain of folate (vitamin B 9 ) requires similar concerted actions, where one enzyme reduces the vitamin to tetrahydrofolate and the other catalyzes polyglutamylation; folate is required for DNA and amino acid synthesis. Thus, the reported research has also revealed a key similarity between two important cellular systems." @default.
• W2891610221 created "2018-09-27" @default.
• W2891610221 creator A5020534066 @default.
• W2891610221 creator A5060396483 @default.
• W2891610221 creator A5065910991 @default.
• W2891610221 date "2018-12-01" @default.
• W2891610221 modified "2023-10-17" @default.
• W2891610221 title "Coenzyme F ₄₂₀ -Dependent Glucose-6-Phosphate Dehydrogenase-Coupled Polyglutamylation of Coenzyme F ₄₂₀ in Mycobacteria" @default.
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• W2891610221 doi "https://doi.org/10.1128/jb.00375-18" @default.
• W2891610221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6222201" @default.
• W2891610221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249701" @default.
• W2891610221 hasPublicationYear "2018" @default.
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