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- W2891610856 startingPage "880" @default.
- W2891610856 abstract "Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the radiographic demonstration of airway enlargement is the common feature of a heterogeneous set of conditions and clinical presentations. No approved therapies exist for the condition other than for bronchiectasis caused by cystic fibrosis. The heterogeneity of bronchiectasis is a major challenge in clinical practice and the main reason for difficulty in achieving endpoints in clinical trials. Recent observations of the past 2 years have improved the understanding of physicians regarding bronchiectasis, and have indicated that it might be more effective to classify patients in a different way. Patients could be categorised according to a heterogeneous group of endotypes (defined by a distinct functional or pathobiological mechanism) or by clinical phenotypes (defined by relevant and common features of the disease). In doing so, more specific therapies needed to effectively treat patients might finally be developed. Here, we describe some of the recent advances in endotyping, genetics, and disease heterogeneity of bronchiectasis including observations related to the microbiome." @default.
- W2891610856 created "2018-09-27" @default.
- W2891610856 creator A5005915390 @default.
- W2891610856 creator A5056681502 @default.
- W2891610856 creator A5074932333 @default.
- W2891610856 date "2018-09-01" @default.
- W2891610856 modified "2023-10-16" @default.
- W2891610856 title "Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity" @default.
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- W2891610856 doi "https://doi.org/10.1016/s0140-6736(18)31767-7" @default.
- W2891610856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173801" @default.
- W2891610856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30215383" @default.
- W2891610856 hasPublicationYear "2018" @default.