FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891611935> ?p ?o ?g. }

• W2891611935 abstract "Introduction Mechanotransduction, the conversion of mechanical cues into biochemical signals, is crucial for many biological processes in plants and animals 1,2 . In mammals, some mechanosensory processes such as touch sensation and vascular development are mediated by the PIEZO family of mechanically activated (MA) ion channels 3-5 . In plants, the impact of gravity or soil properties on root development, wind on stem growth, and turgor pressure on plant-cell size and shape are proposed to involve activation of MA ion channels 6,7 . Homologues of the bacterial MA channel MscS (MSLs) exist in plants, and MSL8 is shown to be involved in pollen hydration 8 ; however, the identity of the MA channels required for most mechanotransduction processes in plants have remained elusive 9 . Here, we identify various members of the 15 OSCA proteins from Arabidopsis thaliana (previously reported as hyperosmolarity sensors 10,11 ) as MA ion channels. Purification and reconstitution of OSCA1.2 in liposomes induced stretch-activated currents, suggesting that OSCAs are inherently mechanosensitive, pore-forming ion channels. This conclusion is confirmed by a high-resolution electron microscopy structure of OSCA1.2 described in a companion paper 12 . Beyond plants, we present evidence that fruit fly, mouse, and human TMEM63 family of proteins, homologues of OSCAs, induce MA currents when expressed in naïve cells. Our results suggest that OSCA/TMEM63 proteins are the largest family of MA ion channels identified, and are conserved across eukaryotes. We anticipate that further characterization of OSCA isoforms which have diverse biophysical properties, will help gain substantial insight on the molecular mechanism of MA ion channel gating and permeation. OSCA1.1 mutant plants have impaired leaf and root growth under stress, potentially linking this ion channel to a mechanosensory role 11 . We expect future studies to uncover novel roles of OSCA/TMEM63 channels in mechanosensory processes across plants and animals." @default.
• W2891611935 created "2018-09-27" @default.
• W2891611935 creator A5007007378 @default.
• W2891611935 creator A5013915280 @default.
• W2891611935 creator A5020755193 @default.
• W2891611935 creator A5053043495 @default.
• W2891611935 creator A5057819986 @default.
• W2891611935 creator A5061962205 @default.
• W2891611935 creator A5066449841 @default.
• W2891611935 creator A5067790213 @default.
• W2891611935 date "2018-09-04" @default.
• W2891611935 modified "2023-10-13" @default.
• W2891611935 title "OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels" @default.
• W2891611935 cites W1974952628 @default.
• W2891611935 cites W1976976361 @default.
• W2891611935 cites W1980802466 @default.
• W2891611935 cites W1999720993 @default.
• W2891611935 cites W2011031006 @default.
• W2891611935 cites W2019101590 @default.
• W2891611935 cites W2023358602 @default.
• W2891611935 cites W2060193072 @default.
• W2891611935 cites W2066069772 @default.
• W2891611935 cites W2076761586 @default.
• W2891611935 cites W2097296613 @default.
• W2891611935 cites W2112956889 @default.
• W2891611935 cites W2155469071 @default.
• W2891611935 cites W2166599924 @default.
• W2891611935 cites W2179432713 @default.
• W2891611935 cites W2256087259 @default.
• W2891611935 cites W2260991120 @default.
• W2891611935 cites W2337520510 @default.
• W2891611935 cites W2468678680 @default.
• W2891611935 cites W2539785878 @default.
• W2891611935 cites W2555705980 @default.
• W2891611935 cites W2599065202 @default.
• W2891611935 cites W2605554157 @default.
• W2891611935 cites W2735586469 @default.
• W2891611935 cites W2760821868 @default.
• W2891611935 cites W2949360706 @default.
• W2891611935 cites W4211168555 @default.
• W2891611935 doi "https://doi.org/10.1101/408732" @default.
• W2891611935 hasPublicationYear "2018" @default.
• W2891611935 type Work @default.
• W2891611935 sameAs 2891611935 @default.
• W2891611935 citedByCount "4" @default.
• W2891611935 countsByYear W28916119352018 @default.
• W2891611935 countsByYear W28916119352022 @default.
• W2891611935 countsByYear W28916119352023 @default.
• W2891611935 crossrefType "posted-content" @default.
• W2891611935 hasAuthorship W2891611935A5007007378 @default.
• W2891611935 hasAuthorship W2891611935A5013915280 @default.
• W2891611935 hasAuthorship W2891611935A5020755193 @default.
• W2891611935 hasAuthorship W2891611935A5053043495 @default.
• W2891611935 hasAuthorship W2891611935A5057819986 @default.
• W2891611935 hasAuthorship W2891611935A5061962205 @default.
• W2891611935 hasAuthorship W2891611935A5066449841 @default.
• W2891611935 hasAuthorship W2891611935A5067790213 @default.
• W2891611935 hasBestOaLocation W28916119351 @default.
• W2891611935 hasConcept C104317684 @default.
• W2891611935 hasConcept C12554922 @default.
• W2891611935 hasConcept C143065580 @default.
• W2891611935 hasConcept C170493617 @default.
• W2891611935 hasConcept C181104049 @default.
• W2891611935 hasConcept C185592680 @default.
• W2891611935 hasConcept C2775988993 @default.
• W2891611935 hasConcept C2779491563 @default.
• W2891611935 hasConcept C4001165 @default.
• W2891611935 hasConcept C50254741 @default.
• W2891611935 hasConcept C55493867 @default.
• W2891611935 hasConcept C86803240 @default.
• W2891611935 hasConcept C87865070 @default.
• W2891611935 hasConcept C95444343 @default.
• W2891611935 hasConceptScore W2891611935C104317684 @default.
• W2891611935 hasConceptScore W2891611935C12554922 @default.
• W2891611935 hasConceptScore W2891611935C143065580 @default.
• W2891611935 hasConceptScore W2891611935C170493617 @default.
• W2891611935 hasConceptScore W2891611935C181104049 @default.
• W2891611935 hasConceptScore W2891611935C185592680 @default.
• W2891611935 hasConceptScore W2891611935C2775988993 @default.
• W2891611935 hasConceptScore W2891611935C2779491563 @default.
• W2891611935 hasConceptScore W2891611935C4001165 @default.
• W2891611935 hasConceptScore W2891611935C50254741 @default.
• W2891611935 hasConceptScore W2891611935C55493867 @default.
• W2891611935 hasConceptScore W2891611935C86803240 @default.
• W2891611935 hasConceptScore W2891611935C87865070 @default.
• W2891611935 hasConceptScore W2891611935C95444343 @default.
• W2891611935 hasLocation W28916119351 @default.
• W2891611935 hasLocation W28916119352 @default.
• W2891611935 hasLocation W28916119353 @default.
• W2891611935 hasOpenAccess W2891611935 @default.
• W2891611935 hasPrimaryLocation W28916119351 @default.
• W2891611935 hasRelatedWork W2092415707 @default.
• W2891611935 hasRelatedWork W2771807434 @default.
• W2891611935 hasRelatedWork W2775897981 @default.
• W2891611935 hasRelatedWork W2989965341 @default.
• W2891611935 hasRelatedWork W3031096035 @default.
• W2891611935 hasRelatedWork W3082536056 @default.
• W2891611935 hasRelatedWork W3122270077 @default.
• W2891611935 hasRelatedWork W3163172095 @default.
• W2891611935 hasRelatedWork W4309046853 @default.

• next