FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891618652> ?p ?o ?g. }

• W2891618652 endingPage "2728" @default.
• W2891618652 startingPage "2717" @default.
• W2891618652 abstract "Ischemia is associated with the pathogenesis of retinal disease, including diabetic retinopathy and glaucoma. As a result, the retinal ischemia/reperfusion injury model has been used to study neurovascular changes. Historically, murine models of retinal disease are established in C57BL/6J (B6) mice, which have been described as type 1-dominant responders. In bacterial keratitis models, B6 mice are susceptible, whereas BALB/cJ (BALB/c; type 2-dominant) mice exhibit a resistant phenotype. As such, we questioned whether the type 1/type 2 paradigm could be extrapolated to events associated with retinal pathogenesis. The current study compares the retinal response of B6 with BALB/c mice to investigate strain-specific differences. Retinas were collected at 2 and 10 days after ischemia/reperfusion injury to examine differences in neurovascular degeneration, leukostasis, oxidative stress, glial activation, and select inflammatory mediators. Although both strains showed signs of retinal injury, significantly more damage was observed in B6 mice. Retinal thickness was reduced and vascular damage was more severe in B6 mice. Exacerbated response to injury in B6 versus BALB/c retinas was further supported by increased leukostasis, inflammatory mediators, reactive oxygen species, and lipid peroxidation. In addition, more terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive cells and increased glial activation were detected in B6 mice. These data indicate that B6 and BALB/c retinas differentially respond to injury, which has broader implications regarding the development and study of retinal diseases." @default.
• W2891618652 created "2018-09-27" @default.
• W2891618652 creator A5019999054 @default.
• W2891618652 creator A5041232217 @default.
• W2891618652 creator A5074723278 @default.
• W2891618652 date "2018-12-01" @default.
• W2891618652 modified "2023-10-01" @default.
• W2891618652 title "A Contrast in Pathogenic Responses between C57BL/6J and BALB/cJ Mice Using a Model of Retinal Injury" @default.
• W2891618652 cites W1483193127 @default.
• W2891618652 cites W1536674483 @default.
• W2891618652 cites W1561882712 @default.
• W2891618652 cites W1601380713 @default.
• W2891618652 cites W1968221108 @default.
• W2891618652 cites W1969075951 @default.
• W2891618652 cites W1977829186 @default.
• W2891618652 cites W1980578349 @default.
• W2891618652 cites W1986564074 @default.
• W2891618652 cites W1997684038 @default.
• W2891618652 cites W1998572804 @default.
• W2891618652 cites W2005767645 @default.
• W2891618652 cites W2013438777 @default.
• W2891618652 cites W2015700821 @default.
• W2891618652 cites W2018887860 @default.
• W2891618652 cites W2019227795 @default.
• W2891618652 cites W2030222823 @default.
• W2891618652 cites W2031740343 @default.
• W2891618652 cites W2045324717 @default.
• W2891618652 cites W2046432700 @default.
• W2891618652 cites W2047640394 @default.
• W2891618652 cites W2049286784 @default.
• W2891618652 cites W2049336254 @default.
• W2891618652 cites W2049903516 @default.
• W2891618652 cites W2056794593 @default.
• W2891618652 cites W2060141430 @default.
• W2891618652 cites W2067215757 @default.
• W2891618652 cites W2072731639 @default.
• W2891618652 cites W2078900534 @default.
• W2891618652 cites W2086852837 @default.
• W2891618652 cites W2087955889 @default.
• W2891618652 cites W2093934354 @default.
• W2891618652 cites W2121618767 @default.
• W2891618652 cites W2128728937 @default.
• W2891618652 cites W2131792018 @default.
• W2891618652 cites W2133766032 @default.
• W2891618652 cites W2138480916 @default.
• W2891618652 cites W2142908091 @default.
• W2891618652 cites W2144394946 @default.
• W2891618652 cites W2153552716 @default.
• W2891618652 cites W2161578081 @default.
• W2891618652 cites W2165057708 @default.
• W2891618652 cites W2396002770 @default.
• W2891618652 cites W2411943442 @default.
• W2891618652 cites W2471832018 @default.
• W2891618652 cites W2728593064 @default.
• W2891618652 cites W2777517651 @default.
• W2891618652 cites W2796822606 @default.
• W2891618652 cites W56512781 @default.
• W2891618652 doi "https://doi.org/10.1016/j.ajpath.2018.08.010" @default.
• W2891618652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284553" @default.
• W2891618652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30236476" @default.
• W2891618652 hasPublicationYear "2018" @default.
• W2891618652 type Work @default.
• W2891618652 sameAs 2891618652 @default.
• W2891618652 citedByCount "8" @default.
• W2891618652 countsByYear W28916186522019 @default.
• W2891618652 countsByYear W28916186522020 @default.
• W2891618652 countsByYear W28916186522021 @default.
• W2891618652 countsByYear W28916186522022 @default.
• W2891618652 countsByYear W28916186522023 @default.
• W2891618652 crossrefType "journal-article" @default.
• W2891618652 hasAuthorship W2891618652A5019999054 @default.
• W2891618652 hasAuthorship W2891618652A5041232217 @default.
• W2891618652 hasAuthorship W2891618652A5074723278 @default.
• W2891618652 hasBestOaLocation W28916186521 @default.
• W2891618652 hasConcept C126322002 @default.
• W2891618652 hasConcept C142724271 @default.
• W2891618652 hasConcept C169760540 @default.
• W2891618652 hasConcept C203014093 @default.
• W2891618652 hasConcept C2777093970 @default.
• W2891618652 hasConcept C2777432695 @default.
• W2891618652 hasConcept C2780114680 @default.
• W2891618652 hasConcept C2780827179 @default.
• W2891618652 hasConcept C2780942790 @default.
• W2891618652 hasConcept C2781040256 @default.
• W2891618652 hasConcept C541997718 @default.
• W2891618652 hasConcept C55493867 @default.
• W2891618652 hasConcept C71924100 @default.
• W2891618652 hasConcept C86803240 @default.
• W2891618652 hasConceptScore W2891618652C126322002 @default.
• W2891618652 hasConceptScore W2891618652C142724271 @default.
• W2891618652 hasConceptScore W2891618652C169760540 @default.
• W2891618652 hasConceptScore W2891618652C203014093 @default.
• W2891618652 hasConceptScore W2891618652C2777093970 @default.
• W2891618652 hasConceptScore W2891618652C2777432695 @default.
• W2891618652 hasConceptScore W2891618652C2780114680 @default.
• W2891618652 hasConceptScore W2891618652C2780827179 @default.
• W2891618652 hasConceptScore W2891618652C2780942790 @default.
• W2891618652 hasConceptScore W2891618652C2781040256 @default.

• next