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- W2891618986 abstract "Background Postoperative nausea and vomiting (PONV) are common and highly distressing following laparoscopic bariatric surgery. However, there is inadequate evidence regarding the impact of combining dexmedetomidine to dexamethasone and ondansetron. We aimed to study the impact of combining dexmedetomidine to dexamethasone and ondansetron in the prevention of PONV. Patients and methods Seventy-two adult patients scheduled for laparoscopic bariatric surgery were randomized in this double-blind study to receive either single dose of dexmedetomidine 1 µg/kg; ondansetron 4 mg; dexamethasone 8 mg (group D, n=36) or ondansetron 4 mg and dexamethasone 8 mg (group B, n=36), after induction of anaesthesia. Anaesthesia administration was performed similarly for both groups using a standard protocol. During the first 24 h postoperatively, the primary outcomes were the incidence of PONV. The severity of PONV and use of rescue antiemetic were the secondary outcomes. χ2-Test and Student’s t-test were utilized to evaluate significant differences in categorical and continuous variables. Results The incidence of PONV was significantly reduced in group D (13.9 vs. 52.8%, P Conclusion Addition of dexmedetomidine to ondansetron and dexamethasone was efficacious in decreasing incidence, severity of PONV, and the total analgesic consumption during the first 24 h after laparoscopic bariatric surgery." @default.
- W2891618986 created "2018-09-27" @default.
- W2891618986 creator A5052437042 @default.
- W2891618986 date "2018-01-01" @default.
- W2891618986 modified "2023-09-27" @default.
- W2891618986 title "Impact of combining dexmedetomidine to ondansetron and dexamethasone for prophylaxis against postoperative nausea and vomiting after laparoscopic bariatric surgery" @default.
- W2891618986 doi "https://doi.org/10.4103/sjamf.sjamf_22_18" @default.
- W2891618986 hasPublicationYear "2018" @default.
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