Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891624460> ?p ?o ?g. }
- W2891624460 endingPage "12295" @default.
- W2891624460 startingPage "12290" @default.
- W2891624460 abstract "A rare-earth metal/alkali metal bimetallic catalyst proved particularly effective for enantioselectively coupling nitroalkanes and α-keto esters in an anti-selective manner to afford synthetically versatile, densely functionalized, and optically active α-nitro tertiary alcohols. A chiral diamide ligand captured two distinct metal cations, giving rise to a catalytically competent solid-phase heterobimetallic catalyst by simple mixing via self-assembly. The advantage of the solid-phase asymmetric catalyst was realized by successful application to the enantio- and diastereoselective reaction in a continuous-flow platform. The use of closely related solvents in terms of structures and polarity parameters, THF and its methylated congener 2-Me-THF, had an unexpectedly large solvent effect both on the reaction rate and the stereoselectivity. The nitroaldol products share a privileged unit for active pharmaceutical ingredients, as demonstrated by the streamlined enantioselective synthesis of the marketed antifungal agents efinaconazole and albaconazole." @default.
- W2891624460 created "2018-09-27" @default.
- W2891624460 creator A5006830322 @default.
- W2891624460 creator A5012101296 @default.
- W2891624460 creator A5024439317 @default.
- W2891624460 creator A5087992950 @default.
- W2891624460 date "2018-09-03" @default.
- W2891624460 modified "2023-10-11" @default.
- W2891624460 title "<i>anti</i>-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients" @default.
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