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• W2891624505 startingPage "63" @default.
• W2891624505 abstract "We investigated the relationship of monocytes, alveolar, and tissue-resident macrophage populations and the development of pulmonary arterial hypertension (PAH) in a nonhuman primate model of HIV infection. A prospective study of simian immunodeficiency virus-associated pulmonary arterial hypertension (SIV-PAH) was done. Rhesus macaques (n = 21) were infected with SIV. Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were analyzed for monocyte and macrophage phenotypes and inflammatory mediators. Serial right heart catheterizations were performed at three time points throughout the study to assess hemodynamic alterations and the development of PAH. All 21 animals showed similar courses of SIV infection with an increasing proinflammatory plasma environment. At 6 months postinfection (mpi), 11 of 21 animals developed SIV-PAH (mPAP ≤25 mmHg; right ventricular systolic pressure [RVSP] ≤36 mmHg). PAH+ animals had an increased frequency of proinflammatory, nonclassical monocytes (CD14dimCD16+) (p = .06) in the peripheral blood and CD14+CCR7-CD163-CD206+ macrophages (p = .04) in BALF compared with PAH- animals at 6 mpi. Increased frequencies of these monocyte and macrophage phenotypes correlated with elevated RVSP (p = .04; p = .03). In addition, PAH+ animals had greater frequencies of tissue resident inflammatory M1-like CD68+STAT1+ (p = .001) and M2a-like CD68+STAT3+ macrophages (p = .003) and a lower frequency of anti-inflammatory M2c-like CD68+STAT6+ macrophages (p = .003) as well as fewer interleukin (IL)-10+ cells (p = .01). The results suggest that HIV-PAH is associated with skewing of monocytes and alveolar macrophages toward a proinflammatory, profibrotic phenotype. Furthermore, PAH+ animals may have diminished capacity to downregulate exaggerated chronic inflammation, as indicated by lower levels of IL-10 in PAH+ animals, contributing to disease progression." @default.
• W2891624505 created "2018-09-27" @default.
• W2891624505 creator A5002529868 @default.
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• W2891624505 creator A5036143002 @default.
• W2891624505 creator A5065154822 @default.
• W2891624505 creator A5088707576 @default.
• W2891624505 date "2019-01-01" @default.
• W2891624505 modified "2023-10-17" @default.
• W2891624505 title "Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection" @default.
• W2891624505 cites W101740868 @default.
• W2891624505 cites W1561369138 @default.
• W2891624505 cites W1888035750 @default.
• W2891624505 cites W1947541914 @default.
• W2891624505 cites W1970866975 @default.
• W2891624505 cites W1973009607 @default.
• W2891624505 cites W1974800854 @default.
• W2891624505 cites W1983456864 @default.
• W2891624505 cites W1984719956 @default.
• W2891624505 cites W1985859986 @default.
• W2891624505 cites W1987414938 @default.
• W2891624505 cites W1988069829 @default.
• W2891624505 cites W1991032340 @default.
• W2891624505 cites W1993897052 @default.
• W2891624505 cites W2002864937 @default.
• W2891624505 cites W2006232527 @default.
• W2891624505 cites W2014217144 @default.
• W2891624505 cites W2015491183 @default.
• W2891624505 cites W2017749666 @default.
• W2891624505 cites W2023703380 @default.
• W2891624505 cites W2024338340 @default.
• W2891624505 cites W2026469629 @default.
• W2891624505 cites W2027033552 @default.
• W2891624505 cites W2028094582 @default.
• W2891624505 cites W2028884555 @default.
• W2891624505 cites W2032171271 @default.
• W2891624505 cites W2032402428 @default.
• W2891624505 cites W2032639324 @default.
• W2891624505 cites W2039110555 @default.
• W2891624505 cites W2045199577 @default.
• W2891624505 cites W2047044941 @default.
• W2891624505 cites W2054472394 @default.
• W2891624505 cites W2056838565 @default.
• W2891624505 cites W2057864569 @default.
• W2891624505 cites W2057934140 @default.
• W2891624505 cites W2061070237 @default.
• W2891624505 cites W2065210647 @default.
• W2891624505 cites W2071913265 @default.
• W2891624505 cites W2073517332 @default.
• W2891624505 cites W2081805594 @default.
• W2891624505 cites W2085887376 @default.
• W2891624505 cites W2087668602 @default.
• W2891624505 cites W2089573422 @default.
• W2891624505 cites W2090210823 @default.
• W2891624505 cites W2092266379 @default.
• W2891624505 cites W2104520807 @default.
• W2891624505 cites W2106336207 @default.
• W2891624505 cites W2113102013 @default.
• W2891624505 cites W2114865585 @default.
• W2891624505 cites W2118846551 @default.
• W2891624505 cites W2120001340 @default.
• W2891624505 cites W2122425744 @default.
• W2891624505 cites W2124656992 @default.
• W2891624505 cites W2125553744 @default.
• W2891624505 cites W2127385800 @default.
• W2891624505 cites W2127845947 @default.
• W2891624505 cites W2128627731 @default.
• W2891624505 cites W2129707656 @default.
• W2891624505 cites W2131701458 @default.
• W2891624505 cites W2135647797 @default.
• W2891624505 cites W2135741165 @default.
• W2891624505 cites W2138694347 @default.
• W2891624505 cites W2144145288 @default.
• W2891624505 cites W2146302858 @default.
• W2891624505 cites W2152284086 @default.
• W2891624505 cites W2155013589 @default.
• W2891624505 cites W2155100711 @default.
• W2891624505 cites W2155444336 @default.
• W2891624505 cites W2157601642 @default.
• W2891624505 cites W2159560463 @default.
• W2891624505 cites W2162297541 @default.
• W2891624505 cites W2163601934 @default.
• W2891624505 cites W2165494158 @default.
• W2891624505 cites W2165528446 @default.
• W2891624505 cites W2169047384 @default.
• W2891624505 cites W2170331970 @default.
• W2891624505 cites W2181762443 @default.
• W2891624505 cites W2419633149 @default.
• W2891624505 cites W2734365706 @default.
• W2891624505 cites W2753114438 @default.
• W2891624505 cites W2796480732 @default.
• W2891624505 cites W2905290778 @default.
• W2891624505 cites W4250194912 @default.
• W2891624505 cites W4290168947 @default.
• W2891624505 doi "https://doi.org/10.1089/aid.2018.0132" @default.
• W2891624505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343195" @default.
• W2891624505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229666" @default.

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