Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891625160> ?p ?o ?g. }
- W2891625160 abstract "ABSTRACT Cis -regulatory elements (CREs) orchestrate the dynamic and diverse transcriptional programs that assemble the human central nervous system (CNS) during development and maintain its function throughout life. Genetic variation within CREs plays a central role in phenotypic variation in complex traits including the risk of developing disease. However, the cellular complexity of the human brain has largely precluded the identification of functional regulatory variation within the human CNS. We took advantage of the retina, a well-characterized region of the CNS with reduced cellular heterogeneity, to establish a roadmap for characterizing regulatory variation in the human CNS. This comprehensive resource of tissue-specific regulatory elements, transcription factor binding, and gene expression programs in three regions of the human visual system (retina, macula, retinal pigment epithelium/choroid) reveals features of regulatory element evolution that shape tissue-specific gene expression programs and defines the regulatory elements with the potential to contribute to mendelian and complex disorders of human vision." @default.
- W2891625160 created "2018-09-27" @default.
- W2891625160 creator A5021548595 @default.
- W2891625160 creator A5026759277 @default.
- W2891625160 creator A5042351241 @default.
- W2891625160 creator A5053453125 @default.
- W2891625160 creator A5068099853 @default.
- W2891625160 creator A5068869541 @default.
- W2891625160 creator A5073701774 @default.
- W2891625160 creator A5077318534 @default.
- W2891625160 creator A5080096392 @default.
- W2891625160 creator A5083846267 @default.
- W2891625160 creator A5089588970 @default.
- W2891625160 date "2018-09-08" @default.
- W2891625160 modified "2023-09-27" @default.
- W2891625160 title "Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal Cis-Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic Variation" @default.
- W2891625160 cites W1490923524 @default.
- W2891625160 cites W1508017125 @default.
- W2891625160 cites W1529788780 @default.
- W2891625160 cites W1865845132 @default.
- W2891625160 cites W1873397816 @default.
- W2891625160 cites W1893444436 @default.
- W2891625160 cites W1964000935 @default.
- W2891625160 cites W1964629749 @default.
- W2891625160 cites W1968488417 @default.
- W2891625160 cites W1979594866 @default.
- W2891625160 cites W1980911974 @default.
- W2891625160 cites W1981030303 @default.
- W2891625160 cites W1986058895 @default.
- W2891625160 cites W2007366236 @default.
- W2891625160 cites W2013741270 @default.
- W2891625160 cites W2014677321 @default.
- W2891625160 cites W2014787267 @default.
- W2891625160 cites W2022753721 @default.
- W2891625160 cites W2023958768 @default.
- W2891625160 cites W2027066480 @default.
- W2891625160 cites W2031241029 @default.
- W2891625160 cites W203520159 @default.
- W2891625160 cites W2035913375 @default.
- W2891625160 cites W2038480702 @default.
- W2891625160 cites W2041171293 @default.
- W2891625160 cites W2041999717 @default.
- W2891625160 cites W2044995136 @default.
- W2891625160 cites W2045362835 @default.
- W2891625160 cites W2055426186 @default.
- W2891625160 cites W2056026334 @default.
- W2891625160 cites W2069089843 @default.
- W2891625160 cites W2074366705 @default.
- W2891625160 cites W2078059415 @default.
- W2891625160 cites W2080152736 @default.
- W2891625160 cites W2090268833 @default.
- W2891625160 cites W2092997109 @default.
- W2891625160 cites W2095903180 @default.
- W2891625160 cites W2102212449 @default.
- W2891625160 cites W2102304447 @default.
- W2891625160 cites W2102619694 @default.
- W2891625160 cites W2106901733 @default.
- W2891625160 cites W2114715558 @default.
- W2891625160 cites W2117757143 @default.
- W2891625160 cites W2121315642 @default.
- W2891625160 cites W2124514674 @default.
- W2891625160 cites W2124707180 @default.
- W2891625160 cites W2124985265 @default.
- W2891625160 cites W2126487187 @default.
- W2891625160 cites W2130774740 @default.
- W2891625160 cites W2131271579 @default.
- W2891625160 cites W2135937351 @default.
- W2891625160 cites W2138242641 @default.
- W2891625160 cites W2138570147 @default.
- W2891625160 cites W2149644313 @default.
- W2891625160 cites W2154746182 @default.
- W2891625160 cites W2154841860 @default.
- W2891625160 cites W2155845672 @default.
- W2891625160 cites W2159686118 @default.
- W2891625160 cites W2164330963 @default.
- W2891625160 cites W2171808845 @default.
- W2891625160 cites W2256016639 @default.
- W2891625160 cites W2259938310 @default.
- W2891625160 cites W2402665099 @default.
- W2891625160 cites W2466523221 @default.
- W2891625160 cites W2536763320 @default.
- W2891625160 cites W2556041461 @default.
- W2891625160 cites W2564176045 @default.
- W2891625160 cites W2591686881 @default.
- W2891625160 cites W2599110791 @default.
- W2891625160 cites W2611327990 @default.
- W2891625160 cites W2747877289 @default.
- W2891625160 cites W2765448062 @default.
- W2891625160 cites W2766078734 @default.
- W2891625160 cites W2773035279 @default.
- W2891625160 cites W2786179447 @default.
- W2891625160 cites W2792498982 @default.
- W2891625160 cites W2799343775 @default.
- W2891625160 cites W2915985519 @default.
- W2891625160 cites W4239872193 @default.
- W2891625160 cites W4247053599 @default.
- W2891625160 doi "https://doi.org/10.1101/412361" @default.
- W2891625160 hasPublicationYear "2018" @default.
- W2891625160 type Work @default.
- W2891625160 sameAs 2891625160 @default.