FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891626898> ?p ?o ?g. }

• W2891626898 endingPage "5725" @default.
• W2891626898 startingPage "5715" @default.
• W2891626898 abstract "The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) catalyzes the first committed step of the mevalonate pathway, which is used across biology in the biosynthesis of countless metabolites. HMGR consumes 2 equiv of the cofactor NAD(P)H to perform the four-electron reduction of HMG-CoA to mevalonate toward the production of steroids and isoprenoids, the largest class of natural products. Recent structural data have shown that HMGR contains a highly mobile C-terminal domain (CTD) that is believed to adopt many different conformations to permit binding and dissociation of the substrate, cofactors, and products at specific points during the reaction cycle. Here, we have characterized the HMGR from Delftia acidovorans as an NADH-specific enzyme and determined crystal structures of the enzyme in unbound, mevalonate-bound, and NADH- and citrate-bound states. Together, these structures depict ligand binding in both the active site and the cofactor-binding site while illustrating how a conserved helical motif confers NAD(P)H cofactor specificity. Unexpectedly, the NADH-bound structure also reveals a new conformation of the CTD, in which the domain has flipped upside-down, while directly binding the cofactor. By capturing these structural snapshots, this work not only expands the known range of HMGR domain movement but also provides valuable insight into the catalytic mechanism of this biologically important enzyme." @default.
• W2891626898 created "2018-09-27" @default.
• W2891626898 creator A5001841943 @default.
• W2891626898 creator A5043092758 @default.
• W2891626898 creator A5079323686 @default.
• W2891626898 date "2018-09-10" @default.
• W2891626898 modified "2023-09-27" @default.
• W2891626898 title "New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase" @default.
• W2891626898 cites W1463493509 @default.
• W2891626898 cites W1496425493 @default.
• W2891626898 cites W1508505082 @default.
• W2891626898 cites W1513449907 @default.
• W2891626898 cites W1541822450 @default.
• W2891626898 cites W1584298557 @default.
• W2891626898 cites W1967185728 @default.
• W2891626898 cites W1974641609 @default.
• W2891626898 cites W1981403571 @default.
• W2891626898 cites W1998333865 @default.
• W2891626898 cites W2004623980 @default.
• W2891626898 cites W2019598308 @default.
• W2891626898 cites W2021933218 @default.
• W2891626898 cites W2033755146 @default.
• W2891626898 cites W2059103037 @default.
• W2891626898 cites W2071475385 @default.
• W2891626898 cites W2076970771 @default.
• W2891626898 cites W2093013278 @default.
• W2891626898 cites W2098390695 @default.
• W2891626898 cites W2104541804 @default.
• W2891626898 cites W2107290798 @default.
• W2891626898 cites W2112940531 @default.
• W2891626898 cites W2131115981 @default.
• W2891626898 cites W2144081223 @default.
• W2891626898 cites W2146087626 @default.
• W2891626898 cites W2147949826 @default.
• W2891626898 cites W2149202606 @default.
• W2891626898 cites W2154197653 @default.
• W2891626898 cites W2154280454 @default.
• W2891626898 cites W2163341755 @default.
• W2891626898 cites W2180229411 @default.
• W2891626898 cites W2316253320 @default.
• W2891626898 cites W2407160000 @default.
• W2891626898 cites W2585093856 @default.
• W2891626898 cites W2773975952 @default.
• W2891626898 doi "https://doi.org/10.1021/acs.biochem.8b00869" @default.
• W2891626898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6319916" @default.
• W2891626898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30199631" @default.
• W2891626898 hasPublicationYear "2018" @default.
• W2891626898 type Work @default.
• W2891626898 sameAs 2891626898 @default.
• W2891626898 citedByCount "7" @default.
• W2891626898 countsByYear W28916268982019 @default.
• W2891626898 countsByYear W28916268982020 @default.
• W2891626898 countsByYear W28916268982021 @default.
• W2891626898 countsByYear W28916268982022 @default.
• W2891626898 countsByYear W28916268982023 @default.
• W2891626898 crossrefType "journal-article" @default.
• W2891626898 hasAuthorship W2891626898A5001841943 @default.
• W2891626898 hasAuthorship W2891626898A5043092758 @default.
• W2891626898 hasAuthorship W2891626898A5079323686 @default.
• W2891626898 hasBestOaLocation W28916268982 @default.
• W2891626898 hasConcept C107824862 @default.
• W2891626898 hasConcept C134651460 @default.
• W2891626898 hasConcept C181199279 @default.
• W2891626898 hasConcept C185592680 @default.
• W2891626898 hasConcept C197957613 @default.
• W2891626898 hasConcept C2779123261 @default.
• W2891626898 hasConcept C2779268744 @default.
• W2891626898 hasConcept C2779982574 @default.
• W2891626898 hasConcept C41183919 @default.
• W2891626898 hasConcept C553450214 @default.
• W2891626898 hasConcept C55493867 @default.
• W2891626898 hasConcept C71240020 @default.
• W2891626898 hasConcept C75520062 @default.
• W2891626898 hasConceptScore W2891626898C107824862 @default.
• W2891626898 hasConceptScore W2891626898C134651460 @default.
• W2891626898 hasConceptScore W2891626898C181199279 @default.
• W2891626898 hasConceptScore W2891626898C185592680 @default.
• W2891626898 hasConceptScore W2891626898C197957613 @default.
• W2891626898 hasConceptScore W2891626898C2779123261 @default.
• W2891626898 hasConceptScore W2891626898C2779268744 @default.
• W2891626898 hasConceptScore W2891626898C2779982574 @default.
• W2891626898 hasConceptScore W2891626898C41183919 @default.
• W2891626898 hasConceptScore W2891626898C553450214 @default.
• W2891626898 hasConceptScore W2891626898C55493867 @default.
• W2891626898 hasConceptScore W2891626898C71240020 @default.
• W2891626898 hasConceptScore W2891626898C75520062 @default.
• W2891626898 hasFunder F4320337354 @default.
• W2891626898 hasIssue "39" @default.
• W2891626898 hasLocation W28916268981 @default.
• W2891626898 hasLocation W28916268982 @default.
• W2891626898 hasLocation W28916268983 @default.
• W2891626898 hasLocation W28916268984 @default.
• W2891626898 hasOpenAccess W2891626898 @default.
• W2891626898 hasPrimaryLocation W28916268981 @default.
• W2891626898 hasRelatedWork W1496425493 @default.
• W2891626898 hasRelatedWork W1542448467 @default.
• W2891626898 hasRelatedWork W169735115 @default.
• W2891626898 hasRelatedWork W1953994264 @default.

• next