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- W2891628681 abstract "Numerous physiological processes vary according to the time of the day in mammals, including the immune defense mechanisms. These circadian rhythms are generated by circadian clocks located in most cell types including cells of the immune system. Recent research has shown that circadian clock function is key to maintaining the homeostasis of the immune system. Indeed, the development and differentiation of different immune cells, and their trafficking between tissues, rely on proper clock function. Disruption of immune system homeostasis can lead to the development of pathological processes such as inflammation or autoimmune diseases. Circadian clocks also control the response of the immune system to inflammatory challenges and infections, and clock dysfunction can provoke or enhance disease. This review focuses on the role of circadian clocks in the homeostasis of immune cells, such as cell recirculation in the peripheral blood and tissues, as well as in the context of inflammation in response to infectious challenges or autoimmune disorders." @default.
- W2891628681 created "2018-09-27" @default.
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- W2891628681 date "2018-10-01" @default.
- W2891628681 modified "2023-10-01" @default.
- W2891628681 title "From immune homeostasis to inflammation, a question of rhythms" @default.
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- W2891628681 doi "https://doi.org/10.1016/j.cophys.2018.09.001" @default.
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