FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891628765> ?p ?o ?g. }

• W2891628765 endingPage "410" @default.
• W2891628765 startingPage "401" @default.
• W2891628765 abstract "Adverse drug reactions (ADRs) contribute to hospitalization but data on its economic burden is scant. Pre-emptive pharmacogenetic (PGx) testing can potentially reduce ADRs and its associated costs. The objectives of this study were to quantify the economic burden of ADRs and to estimate the breakeven cost of pre-emptive PGx testing in Singapore. We collected itemized costs for 1000 random non-elective hospitalizations of adults admitted to a tertiary-care general hospital in Singapore. The presence of ADRs at admission and their clinical characteristics were reported previously. The economic burden of ADRs was assessed from two perspectives: (1) Total cost and (2) incremental costs. The breakeven cost of PGx testing was estimated by dividing avoidable hospitalization costs for ADRs due to selected drugs by the number of patients taking those drugs. The total cost of 81 admissions caused by ADRs was US$570,404. Costs were significantly higher for bleeding/elevated international normalized ratio (US$9906 vs. US$2251, p = 6.58 × 10−3) compared to other ADRs, and for drugs acting on the blood coagulation system (US$9884 vs. US$2229, p = 4.41 × 10−3) compared to other drug classes. There were higher incremental laboratory costs due to ADRs causing or being present at admission. The estimated breakeven cost of a pre-emptive PGx test for patients taking warfarin, clopidogrel, chemotherapeutic and neuropsychiatric drugs was US$114 per patient. These results suggest that future studies designed to directly measure the clinical and cost impact of a pre-emptive genotyping program will help inform clinical practice and health policy decisions." @default.
• W2891628765 created "2018-09-27" @default.
• W2891628765 creator A5013054065 @default.
• W2891628765 creator A5032261500 @default.
• W2891628765 creator A5060981830 @default.
• W2891628765 creator A5061586722 @default.
• W2891628765 creator A5067391389 @default.
• W2891628765 creator A5076398158 @default.
• W2891628765 creator A5086814819 @default.
• W2891628765 date "2018-09-24" @default.
• W2891628765 modified "2023-10-01" @default.
• W2891628765 title "Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults" @default.
• W2891628765 cites W1981137511 @default.
• W2891628765 cites W1995422727 @default.
• W2891628765 cites W2000445173 @default.
• W2891628765 cites W2030352776 @default.
• W2891628765 cites W2037131925 @default.
• W2891628765 cites W2043462668 @default.
• W2891628765 cites W2046345054 @default.
• W2891628765 cites W2052084025 @default.
• W2891628765 cites W2062625526 @default.
• W2891628765 cites W2063280109 @default.
• W2891628765 cites W2064289559 @default.
• W2891628765 cites W2070229706 @default.
• W2891628765 cites W2073386434 @default.
• W2891628765 cites W2075766206 @default.
• W2891628765 cites W2092372657 @default.
• W2891628765 cites W2105178715 @default.
• W2891628765 cites W2143309545 @default.
• W2891628765 cites W2147034970 @default.
• W2891628765 cites W2147614663 @default.
• W2891628765 cites W2149026849 @default.
• W2891628765 cites W2152849583 @default.
• W2891628765 cites W2155140048 @default.
• W2891628765 cites W2158864490 @default.
• W2891628765 cites W2174633205 @default.
• W2891628765 cites W2194698255 @default.
• W2891628765 cites W2198966793 @default.
• W2891628765 cites W2216642993 @default.
• W2891628765 cites W2345597565 @default.
• W2891628765 cites W2405730381 @default.
• W2891628765 cites W2522694534 @default.
• W2891628765 cites W2525184273 @default.
• W2891628765 cites W2570427206 @default.
• W2891628765 cites W2580017562 @default.
• W2891628765 cites W2607472921 @default.
• W2891628765 cites W2622621180 @default.
• W2891628765 cites W2766034136 @default.
• W2891628765 cites W2792968757 @default.
• W2891628765 cites W35832848 @default.
• W2891628765 doi "https://doi.org/10.1038/s41397-018-0053-1" @default.
• W2891628765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250149" @default.
• W2891628765 hasPublicationYear "2018" @default.
• W2891628765 type Work @default.
• W2891628765 sameAs 2891628765 @default.
• W2891628765 citedByCount "14" @default.
• W2891628765 countsByYear W28916287652019 @default.
• W2891628765 countsByYear W28916287652020 @default.
• W2891628765 countsByYear W28916287652021 @default.
• W2891628765 countsByYear W28916287652022 @default.
• W2891628765 countsByYear W28916287652023 @default.
• W2891628765 crossrefType "journal-article" @default.
• W2891628765 hasAuthorship W2891628765A5013054065 @default.
• W2891628765 hasAuthorship W2891628765A5032261500 @default.
• W2891628765 hasAuthorship W2891628765A5060981830 @default.
• W2891628765 hasAuthorship W2891628765A5061586722 @default.
• W2891628765 hasAuthorship W2891628765A5067391389 @default.
• W2891628765 hasAuthorship W2891628765A5076398158 @default.
• W2891628765 hasAuthorship W2891628765A5086814819 @default.
• W2891628765 hasBestOaLocation W28916287652 @default.
• W2891628765 hasConcept C104863432 @default.
• W2891628765 hasConcept C126322002 @default.
• W2891628765 hasConcept C170734499 @default.
• W2891628765 hasConcept C177713679 @default.
• W2891628765 hasConcept C194828623 @default.
• W2891628765 hasConcept C197934379 @default.
• W2891628765 hasConcept C2776301958 @default.
• W2891628765 hasConcept C2777628954 @default.
• W2891628765 hasConcept C2777849778 @default.
• W2891628765 hasConcept C2779161974 @default.
• W2891628765 hasConcept C2780035454 @default.
• W2891628765 hasConcept C2780542314 @default.
• W2891628765 hasConcept C2993432071 @default.
• W2891628765 hasConcept C512399662 @default.
• W2891628765 hasConcept C71924100 @default.
• W2891628765 hasConcept C98274493 @default.
• W2891628765 hasConceptScore W2891628765C104863432 @default.
• W2891628765 hasConceptScore W2891628765C126322002 @default.
• W2891628765 hasConceptScore W2891628765C170734499 @default.
• W2891628765 hasConceptScore W2891628765C177713679 @default.
• W2891628765 hasConceptScore W2891628765C194828623 @default.
• W2891628765 hasConceptScore W2891628765C197934379 @default.
• W2891628765 hasConceptScore W2891628765C2776301958 @default.
• W2891628765 hasConceptScore W2891628765C2777628954 @default.
• W2891628765 hasConceptScore W2891628765C2777849778 @default.
• W2891628765 hasConceptScore W2891628765C2779161974 @default.
• W2891628765 hasConceptScore W2891628765C2780035454 @default.
• W2891628765 hasConceptScore W2891628765C2780542314 @default.

• next