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- W2891630487 abstract "Repetitive activation of non-nociceptive afferents is known to attenuate nociceptive signaling. However, the functional details of how this modulatory process operates are not understood and this has been a barrier in using such stimuli to effectively treat chronic pain. The present study tests the hypothesis that the ability of repeated non-nociceptive stimuli to reduce nociception is a form of generalized habituation from the non-nociceptive stimulus-response pathway to the nociceptive pathway. Habituation training, using non-nociceptive mechanosensory stimuli, did reduce responses to nociceptive thermal stimulation. This generalization of habituation to nociceptive stimuli required endocannabinoid-mediated neuromodulation, although disrupting of endocannabinoid signaling did not affect “direct” habituation of to the non-nociceptive stimulus. Surprisingly, the reduced response to nociceptive stimuli following habituation training was very long-lasting (3–8 days). This long-term habituation required endocannabinoid signaling during the training/acquisition phase, but endocannabinoids were not required for post-training retention phase. The implications of these results are that applying principles of habituation learning could potentially improve anti-nociceptive therapies utilizing repeated non-nociceptive stimulation such as transcutaneous nerve stimulation (TENS), spinal cord stimulation (SCS), or electro-acupuncture." @default.
- W2891630487 created "2018-09-27" @default.
- W2891630487 creator A5083631443 @default.
- W2891630487 creator A5091260987 @default.
- W2891630487 date "2018-11-01" @default.
- W2891630487 modified "2023-10-10" @default.
- W2891630487 title "Are the persistent effects of “gate control” stimulation on nociception a form of generalization of habituation that is endocannabinoid-dependent?" @default.
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- W2891630487 doi "https://doi.org/10.1016/j.nlm.2018.09.001" @default.
- W2891630487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6365193" @default.
- W2891630487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196136" @default.
- W2891630487 hasPublicationYear "2018" @default.
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