Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891632251> ?p ?o ?g. }
- W2891632251 endingPage "8" @default.
- W2891632251 startingPage "1" @default.
- W2891632251 abstract "We have identified a gene YOD1 encoding deubiquitinating enzyme (DUB) responsible for nonsyndromic cleft lip with or without cleft palate (NSCL/P). We aimed to determine the effects of YOD1 RNA interference (RNAi) on cell proliferation and migration, playing an important role in lip and palate formation, and to clarify whether the mechanisms involved TGF-β3 signaling associated with NSCL/P.RNAi was applied to construct vectors expressing YOD1 small interference RNAs (siRNAs). The vectors were transfected into the human oral keratinocytes (HOK) cells. The cell proliferation and migration were evaluated by the cell counting kit-8 (CCK-8) assay and wound healing assay, respectively. The mRNA levels were detected by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). The protein levels were investigated by western blotting.The proliferation of YOD1 siRNA-transfected HOK cells was remarkably inhibited. The migration rate was significantly decreased in the YOD1 siRNA-transfected HOK cells. The TGF-β3 mRNA and protein levels were decreased significantly by siRNA-mediated knockdown of YOD1. YOD1 RNAi reduced the phosphor-Smad2/3 levels significantly.YOD1 RNAi may inhibit cell proliferation and migration associated with the pathogenesis of NSCL/P through TGF-β3 signaling. The study indicates a novel role of YOD1 in regulating TGF-β3 signaling to affect cell proliferation and migration resulting in NSCL/P." @default.
- W2891632251 created "2018-09-27" @default.
- W2891632251 creator A5008833974 @default.
- W2891632251 creator A5010075872 @default.
- W2891632251 creator A5018947273 @default.
- W2891632251 creator A5021262726 @default.
- W2891632251 creator A5041008635 @default.
- W2891632251 creator A5042371132 @default.
- W2891632251 creator A5060697667 @default.
- W2891632251 creator A5062468723 @default.
- W2891632251 creator A5084192361 @default.
- W2891632251 creator A5086013816 @default.
- W2891632251 date "2018-09-13" @default.
- W2891632251 modified "2023-10-18" @default.
- W2891632251 title "Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>3 Signaling Pathway" @default.
- W2891632251 cites W1793785632 @default.
- W2891632251 cites W1964211631 @default.
- W2891632251 cites W1966993307 @default.
- W2891632251 cites W1968818047 @default.
- W2891632251 cites W1972534313 @default.
- W2891632251 cites W1986819584 @default.
- W2891632251 cites W1994132006 @default.
- W2891632251 cites W1996056357 @default.
- W2891632251 cites W2011325147 @default.
- W2891632251 cites W2018454809 @default.
- W2891632251 cites W2019183959 @default.
- W2891632251 cites W2024795849 @default.
- W2891632251 cites W2025530486 @default.
- W2891632251 cites W2035653659 @default.
- W2891632251 cites W2037178132 @default.
- W2891632251 cites W2037407781 @default.
- W2891632251 cites W2038963499 @default.
- W2891632251 cites W2040736830 @default.
- W2891632251 cites W2046107751 @default.
- W2891632251 cites W2048966465 @default.
- W2891632251 cites W2057017284 @default.
- W2891632251 cites W2057078777 @default.
- W2891632251 cites W2064050439 @default.
- W2891632251 cites W2086468991 @default.
- W2891632251 cites W2094165314 @default.
- W2891632251 cites W2099739033 @default.
- W2891632251 cites W2103432808 @default.
- W2891632251 cites W2117200840 @default.
- W2891632251 cites W2144067546 @default.
- W2891632251 cites W2150656559 @default.
- W2891632251 cites W2151049734 @default.
- W2891632251 cites W2170273282 @default.
- W2891632251 cites W2337610563 @default.
- W2891632251 cites W2746234292 @default.
- W2891632251 cites W2790751465 @default.
- W2891632251 cites W2791055636 @default.
- W2891632251 cites W2792432641 @default.
- W2891632251 cites W2802843865 @default.
- W2891632251 cites W2804762627 @default.
- W2891632251 doi "https://doi.org/10.1155/2018/6254308" @default.
- W2891632251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158930" @default.
- W2891632251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345304" @default.
- W2891632251 hasPublicationYear "2018" @default.
- W2891632251 type Work @default.
- W2891632251 sameAs 2891632251 @default.
- W2891632251 citedByCount "8" @default.
- W2891632251 countsByYear W28916322512019 @default.
- W2891632251 countsByYear W28916322512020 @default.
- W2891632251 countsByYear W28916322512021 @default.
- W2891632251 countsByYear W28916322512022 @default.
- W2891632251 countsByYear W28916322512023 @default.
- W2891632251 crossrefType "journal-article" @default.
- W2891632251 hasAuthorship W2891632251A5008833974 @default.
- W2891632251 hasAuthorship W2891632251A5010075872 @default.
- W2891632251 hasAuthorship W2891632251A5018947273 @default.
- W2891632251 hasAuthorship W2891632251A5021262726 @default.
- W2891632251 hasAuthorship W2891632251A5041008635 @default.
- W2891632251 hasAuthorship W2891632251A5042371132 @default.
- W2891632251 hasAuthorship W2891632251A5060697667 @default.
- W2891632251 hasAuthorship W2891632251A5062468723 @default.
- W2891632251 hasAuthorship W2891632251A5084192361 @default.
- W2891632251 hasAuthorship W2891632251A5086013816 @default.
- W2891632251 hasBestOaLocation W28916322511 @default.
- W2891632251 hasConcept C104317684 @default.
- W2891632251 hasConcept C105580179 @default.
- W2891632251 hasConcept C118131993 @default.
- W2891632251 hasConcept C119056186 @default.
- W2891632251 hasConcept C137738243 @default.
- W2891632251 hasConcept C1491633281 @default.
- W2891632251 hasConcept C153911025 @default.
- W2891632251 hasConcept C166703698 @default.
- W2891632251 hasConcept C173396325 @default.
- W2891632251 hasConcept C22615655 @default.
- W2891632251 hasConcept C54009773 @default.
- W2891632251 hasConcept C54355233 @default.
- W2891632251 hasConcept C55493867 @default.
- W2891632251 hasConcept C62112901 @default.
- W2891632251 hasConcept C67705224 @default.
- W2891632251 hasConcept C81885089 @default.
- W2891632251 hasConcept C86803240 @default.
- W2891632251 hasConcept C95444343 @default.
- W2891632251 hasConceptScore W2891632251C104317684 @default.
- W2891632251 hasConceptScore W2891632251C105580179 @default.