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• W2891633475 abstract "Abstract Arsenic exposure causes nonalcoholic steatohepatitis (NASH). Inflammation is a key contributor to the pathology of nonalcoholic fatty liver disease (NAFLD), including NASH. However, it is unclear how arsenic induces inflammation. In mouse livers, we show that arsenic trioxide (As 2 O 3 ) induced NASH, increased autophagy and NLRP3 inflammasome activation, increased lipid accumulation, and resulted in dysregulation of lipid-related genes. Supplemented with taurine (Tau) attenuated the inflammation and autophagy caused by As 2 O 3 . In HepG2 cells, we found that As 2 O 3 -induced pyroptotic cell death was dependent upon the activation of NLRP3 inflammasome, which was CTSB-dependent. In addition, inhibiting autophagy alleviated the As 2 O 3 -induced increase of cytosolic CTSB expression and subsequent release of LDH, activation of the NLRP3 inflammasome, and pyroptosis. Moreover, we found that Tau alleviated As 2 O 3 -induced elevation of autophagy, CTSB expression, and activation of the NLRP3 inflammasome, and reduced the release of LDH, pyroptotic cell death, and inflammation. Interestingly, As 2 O 3 -induced lipid accumulation could not be alleviated by either inhibition of autophagy nor by inhibition of CTSB. Additionally, neither inhibition of the NLRP3 inflammasome or Tau treatment could alleviate lipid accumulation. These results demonstrated that As 2 O 3 -induced pyroptosis involves autophagy, CTSB, and the NLRP3 inflammasome cascade, and that Tau alleviates As 2 O 3 -induced liver inflammation by inhibiting the autophagic-CTSB-NLRP3 inflammasomal pathway rather than decreasing lipid accumulation. These findings give insight into the association of autophagy, inflammation, pyroptosis, and NASH induced by As 2 O 3 ." @default.
• W2891633475 created "2018-09-27" @default.
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• W2891633475 date "2018-09-20" @default.
• W2891633475 modified "2023-10-10" @default.
• W2891633475 title "Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway" @default.
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• W2891633475 doi "https://doi.org/10.1038/s41419-018-1004-0" @default.
• W2891633475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6148242" @default.
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• W2891633475 hasPublicationYear "2018" @default.
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