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• W2891635302 abstract "Abstract Few studies have examined the potential transcription factor (TF) simultaneously associated with cisplatin resistance and metastasis in ovarian cancer. To assess a related mechanism, a 345-channel protein/DNA array and transcriptional activity ELISA were performed to compare the TF activities in the cisplatin-sensitive SKOV3 and cisplatin-resistant SKOV3-DDP cells and in HO-8910 and the homologous highly metastatic HO-8910PM cells. In SKOV3-DDP vs . SKOV3 cells, 43 TFs were up-regulated, while 31 were down-regulated. In HO-8910PM vs . HO-8910 cells, 13 TFs were up-regulated, while 18 were down-regulated. In these two models, 4 TFs ( HOXD8(1), HOXD8(2), RB, RFX1/2/3 ) were simultaneously up-regulated, and 9 TFs ( SRE, FKHR, Angiotensinogen ANG-IRE, Pax2, CD28RC/NF-IL2B, HLF, CPE, CBFB and c-Ets-1 ) were down-regulated. HOXD8 mRNA and protein expression levels measured by reverse transcription polymerase chain reaction and ELISA, respectively, were significantly higher in SKOV3-DDP and HO-8910PM than in their corresponding cell lines (both p < 0.05). In 52 cases of different ovarian disease, the patients with recurrent and cisplatin-resistant ovarian cancer had higher expression levels of HOXD8 than patients with primary malignant tumours ( p = 0.018, p = 0.001) or benign tumours ( p = 0.001, p < 0.001). Taken together, these results suggest that HOXD8 is potentially associated with both cisplatin resistance and metastasis in advanced ovarian cancer." @default.
• W2891635302 created "2018-09-27" @default.
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• W2891635302 date "2018-09-07" @default.
• W2891635302 modified "2023-10-12" @default.
• W2891635302 title "Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer" @default.
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• W2891635302 doi "https://doi.org/10.1038/s41598-018-31030-3" @default.
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