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• W2891635474 endingPage "3051" @default.
• W2891635474 startingPage "3043" @default.
• W2891635474 abstract "Abstract Transglutaminase 2 ( TG 2) is a protein that modulates neuronal survival processes. Although TG 2 is primarily cytosolic, data have suggested the nuclear localization of TG 2 is strongly associated with neuronal viability. Depletion of TG 2 in neurons results in neurite retraction and loss of viability, which is likely due to a dysregulation in gene expression. To begin to understand how TG 2 regulates neuronal gene expression, chromatin immunoprecipitation was performed in neurons with TG 2 overexpression. The resulting genomic DNA was recovered and sequenced. Bioinformatics analyses revealed that a signature DNA motif was enriched in the TG 2 immunoprecipitated genomic DNA . In particular, this motif strongly mapped to a region proximate to the gene Ctss (cathepsin S). Knockdown of TG 2 resulted in a significant increase in cathepsin S expression, which preceded the loss of neuronal viability. This is the first demonstration that TG 2 directly associates with genomic DNA and regulates gene expression in neurons. Given that expression of cathepsin S is increased in neurological disease states, our data suggest that TG 2 may play a role in promoting neuron health in part by repressing the expression of cathepsin S. Overall these data provide new insights into the function of nuclear TG 2 in neurons." @default.
• W2891635474 created "2018-09-27" @default.
• W2891635474 creator A5015387517 @default.
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• W2891635474 date "2018-10-06" @default.
• W2891635474 modified "2023-09-26" @default.
• W2891635474 title "Nuclear transglutaminase 2 directly regulates expression of cathepsin S in rat cortical neurons" @default.
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• W2891635474 doi "https://doi.org/10.1111/ejn.14159" @default.
• W2891635474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30239049" @default.
• W2891635474 hasPublicationYear "2018" @default.
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