FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891635476> ?p ?o ?g. }

• W2891635476 endingPage "154" @default.
• W2891635476 startingPage "146" @default.
• W2891635476 abstract "In order to understand the specific in vivo function of transforming growth factor-beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a conditional knockout method. In the present study, we aimed to further understand the potential role of TGF-β1 in enamel formation.Transgenic mice withoutTGF-β1 in epithelial cells were generated. Scanning electron microscopy and micro-computed tomography analysis were used to detect the dental appearance, enamel microstructure and tooth density. Histological analysis was used to examine the residual organic matrix of enamel. Quantitative real-time polymerase chain reaction was used to analyze the expressions of enamel matrix proteins at the mRNA level.The enamel of mandibular molars and incisors inTGF-β1 conditional knockout mice displayed severe attrition and lower density compared with the wild-type littermates. A slender microstructure of enamel rod was observed, and enamel matrix proteins were retained in the enamel space at the maturation stage in conditional knockout mice. Moreover, the expressions of enamel matrix protein-encoding genes, such as amelogenin (Amelx), ameloblastin (Ambn), Enamelin (Enam) and matrix metalloproteinase-20 (Mmp-20), were increased in enamel organs of conditional knockout mice. On the other hand, the expressions of Amelotin (Amtn), kallikrein-related peptidase-4 (Klk4), C4orf26 and WD repeat-containing protein 72 (Wdr72) were dramatically decreased at the transition and maturation stages.TGF-β1 played an important role in enamel mineralization through decreasing synthesis ofAmelx, Ambn and Enam and increasing synthesis of Klk4, Amtn, Corf26 and Wdr72." @default.
• W2891635476 created "2018-09-27" @default.
• W2891635476 creator A5007171498 @default.
• W2891635476 creator A5014213683 @default.
• W2891635476 creator A5017826971 @default.
• W2891635476 creator A5032163746 @default.
• W2891635476 creator A5059431543 @default.
• W2891635476 creator A5064730472 @default.
• W2891635476 creator A5070725064 @default.
• W2891635476 creator A5073314225 @default.
• W2891635476 creator A5091407828 @default.
• W2891635476 date "2018-12-01" @default.
• W2891635476 modified "2023-09-27" @default.
• W2891635476 title "Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice" @default.
• W2891635476 cites W1963735537 @default.
• W2891635476 cites W1966286998 @default.
• W2891635476 cites W1967275649 @default.
• W2891635476 cites W1976402118 @default.
• W2891635476 cites W1979764375 @default.
• W2891635476 cites W1980188046 @default.
• W2891635476 cites W1984320176 @default.
• W2891635476 cites W2020702809 @default.
• W2891635476 cites W2036043356 @default.
• W2891635476 cites W2038326116 @default.
• W2891635476 cites W2049008122 @default.
• W2891635476 cites W2068521700 @default.
• W2891635476 cites W2072690740 @default.
• W2891635476 cites W2072894795 @default.
• W2891635476 cites W2085638402 @default.
• W2891635476 cites W2102487925 @default.
• W2891635476 cites W2104927261 @default.
• W2891635476 cites W2105892597 @default.
• W2891635476 cites W2117121184 @default.
• W2891635476 cites W2123230395 @default.
• W2891635476 cites W2142455102 @default.
• W2891635476 cites W2143888414 @default.
• W2891635476 cites W2169923698 @default.
• W2891635476 cites W2290721078 @default.
• W2891635476 cites W2412088171 @default.
• W2891635476 cites W2518786240 @default.
• W2891635476 cites W2617899659 @default.
• W2891635476 cites W2628199936 @default.
• W2891635476 doi "https://doi.org/10.1016/j.archoralbio.2018.09.003" @default.
• W2891635476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243146" @default.
• W2891635476 hasPublicationYear "2018" @default.
• W2891635476 type Work @default.
• W2891635476 sameAs 2891635476 @default.
• W2891635476 citedByCount "15" @default.
• W2891635476 countsByYear W28916354762019 @default.
• W2891635476 countsByYear W28916354762020 @default.
• W2891635476 countsByYear W28916354762021 @default.
• W2891635476 countsByYear W28916354762022 @default.
• W2891635476 countsByYear W28916354762023 @default.
• W2891635476 crossrefType "journal-article" @default.
• W2891635476 hasAuthorship W2891635476A5007171498 @default.
• W2891635476 hasAuthorship W2891635476A5014213683 @default.
• W2891635476 hasAuthorship W2891635476A5017826971 @default.
• W2891635476 hasAuthorship W2891635476A5032163746 @default.
• W2891635476 hasAuthorship W2891635476A5059431543 @default.
• W2891635476 hasAuthorship W2891635476A5064730472 @default.
• W2891635476 hasAuthorship W2891635476A5070725064 @default.
• W2891635476 hasAuthorship W2891635476A5073314225 @default.
• W2891635476 hasAuthorship W2891635476A5091407828 @default.
• W2891635476 hasConcept C104317684 @default.
• W2891635476 hasConcept C104392178 @default.
• W2891635476 hasConcept C106434640 @default.
• W2891635476 hasConcept C106487976 @default.
• W2891635476 hasConcept C127716648 @default.
• W2891635476 hasConcept C156887251 @default.
• W2891635476 hasConcept C164659718 @default.
• W2891635476 hasConcept C176860957 @default.
• W2891635476 hasConcept C182704531 @default.
• W2891635476 hasConcept C185592680 @default.
• W2891635476 hasConcept C199106506 @default.
• W2891635476 hasConcept C199343813 @default.
• W2891635476 hasConcept C43617362 @default.
• W2891635476 hasConcept C55493867 @default.
• W2891635476 hasConcept C71924100 @default.
• W2891635476 hasConcept C86803240 @default.
• W2891635476 hasConcept C95444343 @default.
• W2891635476 hasConceptScore W2891635476C104317684 @default.
• W2891635476 hasConceptScore W2891635476C104392178 @default.
• W2891635476 hasConceptScore W2891635476C106434640 @default.
• W2891635476 hasConceptScore W2891635476C106487976 @default.
• W2891635476 hasConceptScore W2891635476C127716648 @default.
• W2891635476 hasConceptScore W2891635476C156887251 @default.
• W2891635476 hasConceptScore W2891635476C164659718 @default.
• W2891635476 hasConceptScore W2891635476C176860957 @default.
• W2891635476 hasConceptScore W2891635476C182704531 @default.
• W2891635476 hasConceptScore W2891635476C185592680 @default.
• W2891635476 hasConceptScore W2891635476C199106506 @default.
• W2891635476 hasConceptScore W2891635476C199343813 @default.
• W2891635476 hasConceptScore W2891635476C43617362 @default.
• W2891635476 hasConceptScore W2891635476C55493867 @default.
• W2891635476 hasConceptScore W2891635476C71924100 @default.
• W2891635476 hasConceptScore W2891635476C86803240 @default.
• W2891635476 hasConceptScore W2891635476C95444343 @default.
• W2891635476 hasFunder F4320321001 @default.

• next