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- W2891636771 endingPage "96" @default.
- W2891636771 startingPage "96" @default.
- W2891636771 abstract "The mineralocorticoid receptor (MR) was first identified as a blood pressure regulator, modulating renal sodium handling in response to its principal ligand aldosterone. The mineralocorticoid receptor is also expressed in many tissues other than the kidney, such as adipose tissue, heart and vasculature. Recent studies have shown that MR plays a relevant role in the control of cardiovascular and metabolic function, as well as in adipogenesis. Dysregulation of aldosterone/MR signaling represents an important cause of disease as high plasma levels of aldosterone are associated with hypertension, obesity and increased cardiovascular risk. Aldosterone displays powerful vascular effects and acts as a potent pro-fibrotic agent in cardiovascular remodeling. Mineralocorticoid receptor activation regulates genes involved in vascular and cardiac fibrosis, calcification and inflammation. This review focuses on the role of novel potential biomarkers related to aldosterone/MR system that could help identify cardiovascular and metabolic detrimental conditions, as a result of altered MR activation. Specifically, we discuss: (1) how MR signaling regulates the number and function of different subpopulations of circulating and intra-tissue immune cells; (2) the role of aldosterone/MR system in mediating cardiometabolic diseases induced by obesity; and (3) the role of several MR downstream molecules as novel potential biomarkers of cardiometabolic diseases, end-organ damage and rehabilitation outcome." @default.
- W2891636771 created "2018-09-27" @default.
- W2891636771 creator A5006816146 @default.
- W2891636771 creator A5020860929 @default.
- W2891636771 creator A5034828130 @default.
- W2891636771 creator A5035684147 @default.
- W2891636771 creator A5041228529 @default.
- W2891636771 date "2018-09-18" @default.
- W2891636771 modified "2023-09-28" @default.
- W2891636771 title "Mineralocorticoid Receptor and Aldosterone-Related Biomarkers of End-Organ Damage in Cardiometabolic Disease" @default.
- W2891636771 cites W124239641 @default.
- W2891636771 cites W137431462 @default.
- W2891636771 cites W1541892895 @default.
- W2891636771 cites W1542359115 @default.
- W2891636771 cites W1554696296 @default.
- W2891636771 cites W1558440797 @default.
- W2891636771 cites W1562962756 @default.
- W2891636771 cites W1577362137 @default.
- W2891636771 cites W1588950918 @default.
- W2891636771 cites W1598667444 @default.
- W2891636771 cites W1874970247 @default.
- W2891636771 cites W1929982114 @default.
- W2891636771 cites W1957009538 @default.
- W2891636771 cites W1965301500 @default.
- W2891636771 cites W1965498876 @default.
- W2891636771 cites W1967659878 @default.
- W2891636771 cites W1968018300 @default.
- W2891636771 cites W1968969423 @default.
- W2891636771 cites W1971838800 @default.
- W2891636771 cites W1974599416 @default.
- W2891636771 cites W1976890810 @default.
- W2891636771 cites W1977662691 @default.
- W2891636771 cites W1980537775 @default.
- W2891636771 cites W1981384991 @default.
- W2891636771 cites W1981637824 @default.
- W2891636771 cites W1982177470 @default.
- W2891636771 cites W1987089303 @default.
- W2891636771 cites W1989890531 @default.
- W2891636771 cites W1991078151 @default.
- W2891636771 cites W1991401277 @default.
- W2891636771 cites W1992509588 @default.
- W2891636771 cites W1992700728 @default.
- W2891636771 cites W1994199177 @default.
- W2891636771 cites W1994764722 @default.
- W2891636771 cites W1996606834 @default.
- W2891636771 cites W1997724745 @default.
- W2891636771 cites W1998702348 @default.
- W2891636771 cites W2000257227 @default.
- W2891636771 cites W2000737837 @default.
- W2891636771 cites W2004152780 @default.
- W2891636771 cites W2005907656 @default.
- W2891636771 cites W2006029554 @default.
- W2891636771 cites W2007573099 @default.
- W2891636771 cites W2008939841 @default.
- W2891636771 cites W2009763464 @default.
- W2891636771 cites W2010088410 @default.
- W2891636771 cites W2010743737 @default.
- W2891636771 cites W2012264731 @default.
- W2891636771 cites W2013859358 @default.
- W2891636771 cites W2015497140 @default.
- W2891636771 cites W2019182494 @default.
- W2891636771 cites W2020602591 @default.
- W2891636771 cites W2023943642 @default.
- W2891636771 cites W2028235817 @default.
- W2891636771 cites W2029767886 @default.
- W2891636771 cites W2034132135 @default.
- W2891636771 cites W2036139926 @default.
- W2891636771 cites W2039132338 @default.
- W2891636771 cites W2040125440 @default.
- W2891636771 cites W2041931673 @default.
- W2891636771 cites W2042886180 @default.
- W2891636771 cites W2042977980 @default.
- W2891636771 cites W2048760408 @default.
- W2891636771 cites W2051136980 @default.
- W2891636771 cites W2051250190 @default.
- W2891636771 cites W2052787253 @default.
- W2891636771 cites W2052968067 @default.
- W2891636771 cites W2053759435 @default.
- W2891636771 cites W2054080413 @default.
- W2891636771 cites W2055496662 @default.
- W2891636771 cites W2058598432 @default.
- W2891636771 cites W2062756785 @default.
- W2891636771 cites W2066371543 @default.
- W2891636771 cites W2071656461 @default.
- W2891636771 cites W2073760548 @default.
- W2891636771 cites W2074692187 @default.
- W2891636771 cites W2074783524 @default.
- W2891636771 cites W2074958057 @default.
- W2891636771 cites W2075323044 @default.
- W2891636771 cites W2077000998 @default.
- W2891636771 cites W2080451201 @default.
- W2891636771 cites W2080532540 @default.
- W2891636771 cites W2081508823 @default.
- W2891636771 cites W2081550911 @default.
- W2891636771 cites W2082324941 @default.
- W2891636771 cites W2082621391 @default.
- W2891636771 cites W2083760388 @default.
- W2891636771 cites W2085992967 @default.