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• W2891636798 abstract "Abstract State-dependent memory describes a phenomenon that memory will be efficiently retrieved only when the brain state during retrieval matches the state during encoding. While a variety of psychoactive drugs, such as ethanol, cocaine, morphine and NMDA receptor antagonists, are able to induce state-dependent memory, the biological hallmark of brain state and neural mechanism of its regulation are still unknown. In this study, we found that MK-801 enhanced delta oscillations in awake mice, representing a drug-induced brain state, in which fear memory could only be successfully retrieved when the same drug condition was presented. We identified a key nucleus, mammillary body (MB), which regulates the specific brain state associated with MK-801. Chemogenetic silencing of MB neurons enhanced cortical delta oscillations and generated state-dependent memory. Moreover, optogenetic reconstitution of delta oscillations alone facilitated retrieval of fear memory encoded under MK-801. Our results indicated that delta oscillations in awake animals defined a specific brain state, in which memory formed is inaccessible under the normal condition, shining light on the neural mechanism underlying the fluctuation of memory retrieval and the role of MB in memory encoding and recall." @default.
• W2891636798 created "2018-09-27" @default.
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• W2891636798 date "2018-09-07" @default.
• W2891636798 modified "2023-10-10" @default.
• W2891636798 title "Mammillary body regulates state-dependent fear by alternating cortical oscillations" @default.
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• W2891636798 doi "https://doi.org/10.1038/s41598-018-31622-z" @default.
• W2891636798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128928" @default.
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• W2891636798 hasPublicationYear "2018" @default.
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