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- W2891640476 endingPage "e0203707" @default.
- W2891640476 startingPage "e0203707" @default.
- W2891640476 abstract "Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality. Here we show that acute hyperammonemia strongly enhances transamination-dependent formation of osmolytic glutamine and excitatory glutamate, thereby inducing neurotoxicity and death in ammoniotelic zebrafish larvae via synergistically acting overactivation of NMDA receptors and bioenergetic impairment induced by depletion of 2-oxoglutarate. Intriguingly, specific and irreversible inhibition of ornithine aminotransferase (OAT) by 5-fluoromethylornithine rescues zebrafish from lethal concentrations of ammonium acetate and corrects hyperammonemia-induced biochemical alterations. Thus, OAT inhibition is a promising and effective therapeutic approach for preventing neurotoxicity and mortality in acute hyperammonemia." @default.
- W2891640476 created "2018-09-27" @default.
- W2891640476 creator A5039397033 @default.
- W2891640476 creator A5045061445 @default.
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- W2891640476 creator A5066002159 @default.
- W2891640476 creator A5072666778 @default.
- W2891640476 creator A5090027115 @default.
- W2891640476 date "2018-09-10" @default.
- W2891640476 modified "2023-10-11" @default.
- W2891640476 title "Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase" @default.
- W2891640476 cites W1026634013 @default.
- W2891640476 cites W1135605424 @default.
- W2891640476 cites W114794933 @default.
- W2891640476 cites W1462339705 @default.
- W2891640476 cites W1507443798 @default.
- W2891640476 cites W1553089765 @default.
- W2891640476 cites W1572396400 @default.
- W2891640476 cites W1583310650 @default.
- W2891640476 cites W1593555249 @default.
- W2891640476 cites W1599125820 @default.
- W2891640476 cites W1686065874 @default.
- W2891640476 cites W1775749144 @default.
- W2891640476 cites W1918304474 @default.
- W2891640476 cites W194348669 @default.
- W2891640476 cites W1968004265 @default.
- W2891640476 cites W1971557904 @default.
- W2891640476 cites W1971822008 @default.
- W2891640476 cites W1973715876 @default.
- W2891640476 cites W1974918085 @default.
- W2891640476 cites W1981762460 @default.
- W2891640476 cites W1988299561 @default.
- W2891640476 cites W1988931872 @default.
- W2891640476 cites W1992521533 @default.
- W2891640476 cites W1996979685 @default.
- W2891640476 cites W2000345489 @default.
- W2891640476 cites W2003467764 @default.
- W2891640476 cites W2009264592 @default.
- W2891640476 cites W2011149655 @default.
- W2891640476 cites W2016333239 @default.
- W2891640476 cites W2016560100 @default.
- W2891640476 cites W2016575029 @default.
- W2891640476 cites W2023811880 @default.
- W2891640476 cites W2033678540 @default.
- W2891640476 cites W2034517058 @default.
- W2891640476 cites W2035334102 @default.
- W2891640476 cites W2036650593 @default.
- W2891640476 cites W2044389563 @default.
- W2891640476 cites W2049162853 @default.
- W2891640476 cites W2050226347 @default.
- W2891640476 cites W2052557841 @default.
- W2891640476 cites W2053188090 @default.
- W2891640476 cites W2053755663 @default.
- W2891640476 cites W2054224074 @default.
- W2891640476 cites W2056961426 @default.
- W2891640476 cites W2059027049 @default.
- W2891640476 cites W2059267377 @default.
- W2891640476 cites W2059369605 @default.
- W2891640476 cites W2062469344 @default.
- W2891640476 cites W2066324474 @default.
- W2891640476 cites W2067767758 @default.
- W2891640476 cites W2068687319 @default.
- W2891640476 cites W2071364408 @default.
- W2891640476 cites W2072494956 @default.
- W2891640476 cites W2079015880 @default.
- W2891640476 cites W2083201980 @default.
- W2891640476 cites W2085442218 @default.
- W2891640476 cites W2087148853 @default.
- W2891640476 cites W2092093623 @default.
- W2891640476 cites W2092251618 @default.
- W2891640476 cites W2095263564 @default.
- W2891640476 cites W2105991652 @default.
- W2891640476 cites W2112076385 @default.
- W2891640476 cites W2114252949 @default.
- W2891640476 cites W2122102597 @default.
- W2891640476 cites W2125349610 @default.
- W2891640476 cites W2129780146 @default.
- W2891640476 cites W2140899588 @default.
- W2891640476 cites W2142582331 @default.
- W2891640476 cites W2146648310 @default.
- W2891640476 cites W2150349809 @default.
- W2891640476 cites W2156304113 @default.
- W2891640476 cites W2161270697 @default.
- W2891640476 cites W2163234334 @default.
- W2891640476 cites W2170491580 @default.
- W2891640476 cites W2170974856 @default.
- W2891640476 cites W2171111385 @default.
- W2891640476 cites W2180322475 @default.
- W2891640476 cites W2271042168 @default.
- W2891640476 cites W2316145923 @default.
- W2891640476 cites W2336128275 @default.
- W2891640476 cites W2507834766 @default.
- W2891640476 cites W2521316143 @default.
- W2891640476 cites W2522684444 @default.
- W2891640476 cites W2626554690 @default.
- W2891640476 cites W400393626 @default.
- W2891640476 doi "https://doi.org/10.1371/journal.pone.0203707" @default.
- W2891640476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6130883" @default.