Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891646580> ?p ?o ?g. }
- W2891646580 abstract "Understanding the key factors for successful subcellular compartment targeting for cargo delivery systems is of great interest in a variety of fields such as bionanotechnology, cell biology, and nanotherapies. However, the fundamental basis for intracellular transportation with these systems has thus far rarely been discussed. As a cargo vector, porous coordination cages (PCCs) have great potential for use in cancer nanotherapy and to elucidate fundamental insight regarding subcellular compartment targeting. Herein, it is shown that the transportation of PCC cargo vectors though various subcellular barriers of the mammalian cell can be manipulated by tuning the vector's electronic property and surface affinity. It is found that the PCCs become selectively aggregated at the cell membrane, the cytoplasm, or the nucleus, respectively. When a DNA topoisomerase inhibitor is delivered into the nucleus by a neutral and lipophilic PCC, the anticancer efficacy is dramatically improved. The findings shed light to tune the interactions at the bio-nano interface. This study provides a key strategy for future work in targeting specific cell organelles for cell imaging, cargo delivery, and therapy. This research also offers key insight into the engineering of nanoscopic materials for furnishing cell organelle-specificity." @default.
- W2891646580 created "2018-09-27" @default.
- W2891646580 creator A5023573296 @default.
- W2891646580 creator A5031224601 @default.
- W2891646580 creator A5035298559 @default.
- W2891646580 creator A5052495835 @default.
- W2891646580 creator A5055843017 @default.
- W2891646580 creator A5060991172 @default.
- W2891646580 creator A5061803425 @default.
- W2891646580 creator A5068538895 @default.
- W2891646580 creator A5077445375 @default.
- W2891646580 date "2018-09-17" @default.
- W2891646580 modified "2023-10-15" @default.
- W2891646580 title "Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy" @default.
- W2891646580 cites W120156214 @default.
- W2891646580 cites W1536538430 @default.
- W2891646580 cites W1584683177 @default.
- W2891646580 cites W1820499608 @default.
- W2891646580 cites W1853486167 @default.
- W2891646580 cites W1974945118 @default.
- W2891646580 cites W1977788018 @default.
- W2891646580 cites W1981009270 @default.
- W2891646580 cites W1987678987 @default.
- W2891646580 cites W1990181744 @default.
- W2891646580 cites W2000096824 @default.
- W2891646580 cites W2007903740 @default.
- W2891646580 cites W2008708346 @default.
- W2891646580 cites W2015757953 @default.
- W2891646580 cites W2016184924 @default.
- W2891646580 cites W2016229092 @default.
- W2891646580 cites W2021721971 @default.
- W2891646580 cites W2025173648 @default.
- W2891646580 cites W2041270553 @default.
- W2891646580 cites W2041471015 @default.
- W2891646580 cites W2042143995 @default.
- W2891646580 cites W2046890107 @default.
- W2891646580 cites W2047247630 @default.
- W2891646580 cites W2053272866 @default.
- W2891646580 cites W2053610032 @default.
- W2891646580 cites W2055904232 @default.
- W2891646580 cites W2066019921 @default.
- W2891646580 cites W2069537362 @default.
- W2891646580 cites W2070003597 @default.
- W2891646580 cites W2070901146 @default.
- W2891646580 cites W2074739302 @default.
- W2891646580 cites W2097203662 @default.
- W2891646580 cites W2106955414 @default.
- W2891646580 cites W2112607530 @default.
- W2891646580 cites W2115749410 @default.
- W2891646580 cites W2117698646 @default.
- W2891646580 cites W2118608275 @default.
- W2891646580 cites W2120680970 @default.
- W2891646580 cites W2129153045 @default.
- W2891646580 cites W2133336042 @default.
- W2891646580 cites W2133391229 @default.
- W2891646580 cites W2134579258 @default.
- W2891646580 cites W2143566830 @default.
- W2891646580 cites W2152041153 @default.
- W2891646580 cites W2153262958 @default.
- W2891646580 cites W2156014915 @default.
- W2891646580 cites W2158248025 @default.
- W2891646580 cites W2160099491 @default.
- W2891646580 cites W2162175822 @default.
- W2891646580 cites W2171230923 @default.
- W2891646580 cites W2208284809 @default.
- W2891646580 cites W2217343864 @default.
- W2891646580 cites W2316636592 @default.
- W2891646580 cites W2323286348 @default.
- W2891646580 cites W2323819656 @default.
- W2891646580 cites W2324880813 @default.
- W2891646580 cites W2331740566 @default.
- W2891646580 cites W2332304057 @default.
- W2891646580 cites W2531212443 @default.
- W2891646580 cites W2787373444 @default.
- W2891646580 cites W3138607029 @default.
- W2891646580 cites W4234207749 @default.
- W2891646580 cites W4238414555 @default.
- W2891646580 doi "https://doi.org/10.1002/smll.201802709" @default.
- W2891646580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6563816" @default.
- W2891646580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30222252" @default.
- W2891646580 hasPublicationYear "2018" @default.
- W2891646580 type Work @default.
- W2891646580 sameAs 2891646580 @default.
- W2891646580 citedByCount "29" @default.
- W2891646580 countsByYear W28916465802019 @default.
- W2891646580 countsByYear W28916465802020 @default.
- W2891646580 countsByYear W28916465802021 @default.
- W2891646580 countsByYear W28916465802022 @default.
- W2891646580 countsByYear W28916465802023 @default.
- W2891646580 crossrefType "journal-article" @default.
- W2891646580 hasAuthorship W2891646580A5023573296 @default.
- W2891646580 hasAuthorship W2891646580A5031224601 @default.
- W2891646580 hasAuthorship W2891646580A5035298559 @default.
- W2891646580 hasAuthorship W2891646580A5052495835 @default.
- W2891646580 hasAuthorship W2891646580A5055843017 @default.
- W2891646580 hasAuthorship W2891646580A5060991172 @default.
- W2891646580 hasAuthorship W2891646580A5061803425 @default.
- W2891646580 hasAuthorship W2891646580A5068538895 @default.
- W2891646580 hasAuthorship W2891646580A5077445375 @default.
- W2891646580 hasBestOaLocation W28916465802 @default.